Endobronchial Ultrasound and Lymphoproliferative Disorders: A Retrospective Study

Iqbal, Seher; DePew, Zachary S.; Kurtin, Paul J.; Sykes, Anne Marie; Johnson, Geoffrey B.; Edell, Eric S.; Habermann, Thomas M.; Maldonado, Fabien

doi:10.1016/j.athoracsur.2012.08.051

Cited by 45 publications

(46 citation statements)

References 20 publications

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“…In cases of de novo lymphoma, the diagnostic accuracy of EBUS-TBNA was found to be very low, despite underrepresentation of Hodgkin and high-grade NHL cases in these patient cohorts (25-51%), which questions its clinical role in this context (14,18). Moreover, the ability of FNAC in general and EBUS-TBNA specifically to accurately subtype lymphoma has been questioned (5,14,18). The use of EBUS-TBNA in the diagnosis of mediastinal lymphomas is therefore uncertain and of questionable value in cases of de novo lymphoma.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies that evaluated the role of EBUS-TBNA in lymphoma diagnosis (14-18) reported mostly on cases with suspected disease relapse; they included only a very small number of high-grade NHL or Hodgkin lymphomas and provided limited data on further lymphoma subclassification. In cases of de novo lymphoma, the diagnostic accuracy of EBUS-TBNA was found to be very low, despite underrepresentation of Hodgkin and high-grade NHL cases in these patient cohorts (25-51%), which questions its clinical role in this context (14,18). Moreover, the ability of FNAC in general and EBUS-TBNA specifically to accurately subtype lymphoma has been questioned (5,14,18).…”

Section: Discussionmentioning

confidence: 99%

“…The development of endobronchial ultrasound (EBUS), which allows ultrasoundguided aspiration of mediastinal and pulmonary lymph nodes and masses (EBUS transbronchial needle aspiration [TBNA]), offers the opportunity to incorporate FNAC to the diagnosis and management of mediastinal lymphoid neoplasms, which had hitherto required sampling by more invasive techniques, such as mediastinoscopy, mediastinotomy, or surgical thoracoscopy. Although there is support for the use of EBUS-TBNA in lung cancer (9)(10)(11)(12) and in the evaluation of isolated mediastinal lymphadenopathy (13), there is limited information of its value in the diagnosis and management of lymphoma (14)(15)(16)(17)(18). The ability of FNAC in general (5) and EBUS-TBNA specifically (14,18) to correctly diagnose and subtype lymphoma has been questioned.…”

mentioning

confidence: 99%

“…Although there is support for the use of EBUS-TBNA in lung cancer (9)(10)(11)(12) and in the evaluation of isolated mediastinal lymphadenopathy (13), there is limited information of its value in the diagnosis and management of lymphoma (14)(15)(16)(17)(18). The ability of FNAC in general (5) and EBUS-TBNA specifically (14,18) to correctly diagnose and subtype lymphoma has been questioned. In this study we investigated the accuracy of diagnosis and subtyping of mediastinal lymphoma by multimodality evaluation of EBUS-TBNA and assessed its role in the investigation of suspected lymphoma relapse.…”

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confidence: 99%

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Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration

Moonim¹,

Breen²,

Fields

et al. 2013

Am J Respir Crit Care Med

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Rationale: The current management of lymphoma requires accurate diagnosis and subtyping of de novo lymphoma and of relapsed or refractory lymphoma in known cases. The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the clinical management of lymphomas is unclear. Objectives: To investigate the use of EBUS-TBNA in the diagnosis of de novo and relapsed mediastinal lymphomas. Methods: A total of 2,256 consecutive patients who underwent EBUS-TBNA in a tertiary center between February 2008 and April 2013 were prospectively evaluated. The diagnostic accuracy and clinical use of EBUS-TBNA in 100 cases of de novo or suspected relapsed mediastinal lymphoma was investigated by comparing EBUS-TBNA diagnosis with the final diagnosis. Measurements and Main Results: De novo mediastinal lymphoma was correctly diagnosed by EBUS-TBNA in 45 (88%) of 51 and relapsed lymphoma in 15 (100%) of 15 lymphoma cases. EBUS-TBNA accurately established a diagnosis other than lymphoma in 32 (97%) of 33 patients with suspected lymphoma relapse. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EBUS-TBNA in the diagnosis of mediastinal lymphoma were 89%, 97%, 98%, 83%, and 91%, respectively. Sensitivity of EBUS-TBNA in subtyping lymphomas into high-grade non-Hodgkin lymphoma, low-grade non-Hodgkin lymphoma, and Hodgkin lymphoma was 90%, 100%, and 79%, respectively. EBUS-TBNA diagnosis was adequate for clinical management in 84 (84%) of 100 cases. Conclusions: Multimodality evaluation of EBUS-TBNA can be successful in the diagnosis of de novo mediastinal lymphomas and is ideally suited in distinguishing lymphoma relapse from alternative pathologies; it is least sensitive in subtyping Hodgkin lymphoma.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration

Moonim¹,

Breen²,

Fields

et al. 2013

Am J Respir Crit Care Med

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“…In a recent retrospective analysis, the overall sensitivity and negative predictive value of EBUS-TBNA in diagnosing lymphoma were 65% and 96%, respectively (38). However, it is important to note that other studies over the last 8-year have found wide variability in the sensitivity of EBUS-TBNA for lymphoma (39)(40)(41)(42)(43)(44)(45). Most studies are limited by small sample sizes and differences in disease recurrence, as well as mixtures of patients with Hodgkins lymphoma (HL) and non-Hodgkins lymphoma (NHL).…”

Section: Ebusmentioning

confidence: 99%

The role of bronchoscopy in the diagnosis of airway disease

Paradis¹,

Dixon²,

Tieu³

2016

J. Thorac. Dis.

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Endoscopy of the airway is a valuable tool for the evaluation and management of airway disease. It can be used to evaluate many different bronchopulmonary diseases including airway foreign bodies, tumors, infectious and inflammatory conditions, airway stenosis, and bronchopulmonary hemorrhage. Traditionally, options for evaluation were limited to flexible and rigid bronchoscopy. Recently, more sophisticated technology has led to the development of endobronchial ultrasound (EBUS) and electromagnetic navigational bronchoscopy (ENB). These technological advances, combined with increasing provider experience have resulted in a higher diagnostic yield with endoscopic biopsies. This review will focus on the role of bronchoscopy, including EBUS, ENB, and rigid bronchoscopy in the diagnosis of bronchopulmonary diseases. In addition, it will cover the anesthetic considerations, equipment, diagnostic yield, and potential complications.

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Convex‐Probe Ultrasonography in Flexible Bronchoscopy

Pattison¹,

Yasufuku²

2020

Flexible Bronchoscopy

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Endobronchial Ultrasound and Lymphoproliferative Disorders: A Retrospective Study

Cited by 45 publications

References 20 publications

Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration

Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration

The role of bronchoscopy in the diagnosis of airway disease

Convex‐Probe Ultrasonography in Flexible Bronchoscopy

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