Endobronchial Ultrasound-Driven Biopsy in the Diagnosis of Peripheral Lung Lesions

Paone, Gregorino; Nicastri, Emanuele; Lucantoni, Gabriele; Iacono, Raffaele Dello; Battistoni, Paolo; D'Angeli, Anna Lisa; Galluccio, Giovanni

doi:10.1378/chest.128.5.3551

Cited by 197 publications

(153 citation statements)

References 24 publications

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“…Endobronchial ultrasonography (EBUS) has been used for imaging guidance for TBB of PPLs [6,7]. Furthermore, Kurimoto et al and our own preliminary study have shown the feasibility and effectiveness of TBB using EBUS with a guide sheath (EBUS-GS) [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions

Mizugaki¹,

Shinagawa²,

Kanegae³

et al. 2010

Lung Cancer

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SummaryTo evaluate the combination of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) and positron emission tomography with fluorodeoxyglucose (FDG-PET) for the diagnosis of small peripheral pulmonary lesions (PPLs) ≤30 mm in mean diameter. A total of 74 PPLs (69.2%) were diagnosed by TBB using EBUS-GS with X-ray fluoroscopy. Diagnostic yield by FDG-PET was 78.5% for the 107 PPLs examined. Diagnostic yield with the combination of TBB using EBUS-GS and FDG-PET (90.7%) was significantly higher compared with that for each procedure alone. A significant increment in diagnostic yield with this combination was seen for PPLs >20 mm and ≤30 mm and for malignant lesions. Combination of TBB using EBUS-GS and FDG-PET is useful for the diagnosis of small PPLs.-3 -

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Section: Introductionmentioning

confidence: 99%

Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions

Mizugaki¹,

Shinagawa²,

Kanegae³

et al. 2010

Lung Cancer

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“…Bronchoscopy may be aided by guidance methods such as fluoroscopy [6,7], virtual bronchoscopy [8], endobronchial ultrasound (EBUS) [7], or electromagnetic navigation (EMN) [9]. The highest diagnostic yield is associated with EBUS and/or EMN guidance [9].…”

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confidence: 99%

Radial probe EBUSversusCT-guided needle biopsy for evaluation of peripheral pulmonary lesions: an economic analysis

2012

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Selection of the optimal procedure for minimally invasive diagnosis of peripheral pulmonary lesions (PPLs) may be based on clinical factors; however, selection of diagnostic strategy may also be influenced by cost. Economic analysis of minimally invasive diagnosis of PPL has not been performed previously.Decision-tree analysis was applied to compare downstream costs of endobronchial ultrasoundguided transbronchial lung biopsy (EBUS-TBLB) with computed tomography-guided percutaneous needle biopsy (CT-PNB). Calculations were based on real costs derived from patient data. Sensitivity analyses and probabilistic sensitivity analysis were undertaken to identify the more cost-beneficial approach for varying input parameter values. Cost-effectiveness calculations were based on estimated disutility, according to the wait-trade-off technique.For base-case analysis, initial evaluation with CT-PNB was cost-beneficial (AU$2,724 versus EBUS-TBLB AU$2,748). The variable which exerted the most influence on cost-benefit outcomes was the cost of managing complications. CT-PNB remained the more cost-effective procedure at base-case parameters, although thresholds were identified during sensitivity analysis where EBUS-TBLB became more cost-effective.The costs of EBUS-TBLB and CT-PNB to evaluate PPL appear to be equivalent, but specific clinicalradiologic factors known to influence procedural outcomes will influence cost-benefit outcomes. Further evaluation of patient preferences and their influence on cost-effectiveness are required.

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“…The average detection rate for cancer for lesions below 3 cm were similar in studies with EBUS (304/481 (63 %)) and in studies without EBUS (407/659 (62 %)). (Values from Table 2 and Table 3) One randomised trial found an increase in diagnostic yield with EBUS for small peripheral lesions when experienced physicians performed EBUS in selected patients (158). However, a comparison of all published studies did not reveal any significant benefit of EBUS.…”

Section: Comparison Of Ebus and Non-ebus For Peripheral Lesionsmentioning

confidence: 99%

“…Paone et al performed a randomised trial with sample size calculation, but without a conclusion for the mnumber needed in the study (158). Two experienced physicians performed all procedures.…”

Section: Comparison Of Ebus and Non-ebus For Peripheral Lesionsmentioning

confidence: 99%

A randomised trial of endobronchial ultrasound guided sampling in peripheral lung lesions

Roth¹,

Eagan²,

Andreassen³

et al. 2011

Lung Cancer

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Endobronchial Ultrasound-Driven Biopsy in the Diagnosis of Peripheral Lung Lesions

Cited by 197 publications

References 24 publications

Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions

Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions

Radial probe EBUSversusCT-guided needle biopsy for evaluation of peripheral pulmonary lesions: an economic analysis

A randomised trial of endobronchial ultrasound guided sampling in peripheral lung lesions

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