Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes

Klisić, Aleksandra; Kavarić, Nebojša; Stanišić, Verica; Vujčić, Sanja; Spasojević‐Kalimanovska, Vesna; Ninić, Ana; Kotur‐Stevuljević, Jelena

doi:10.5114/aoms.2019.87541

Cited by 47 publications

(48 citation statements)

References 33 publications

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“…Other mechanisms may also be involved in radiation-induced cardiotoxicity. The serum level of endocan has been identified as a risk factor for cardiotoxicity [35,36]. The production of nitric oxide (NO) (both inducible NO and endothelial NO) is another risk factor associated with radiation-induced lethal injury [37], and a recent study shows that the NO pathway plays a key role in ischemia/reperfusion-induced injury [38].…”

Section: Discussionmentioning

confidence: 99%

Montelukast protects H9c2 cardiomyocytes against radiation-induced toxicity

Zhang

Zheng²,

Wang³

2021

Arch Med Sci

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IntroductionRadiation-induced cardiotoxicity is a major concern following radiation treatment or involuntary radiation exposure. The normal functionality of cardiomyocytes becomes limited, which results in deleterious consequences, including an increase in the secretion of proinflammatory factors, such as HMGB1, and oxidative stress due to increased production of NOX4 and ROS. Radiation exposure results in disruption of the Bax/Bcl-2 ratio, increased expression of cytochrome c, and increased cleavage of caspase 3, thereby promoting cardiotoxicity and excessive apoptosis of cardiomyocytes. The cysLT1R antagonist montelukast is commonly used in the treatment of asthma, with recent studies showing potential for this drug in treating other diseases.Material and methodsRat H9c2 cardiomyocytes were used in all the vitro experiments. The MTT assay was used to determined the The Cell viability; DCFH-DA staning was used to measure the intracellular ROS; and TMRM method was used to determine the level of ΔΨm in H9c2 cells; All mRNA levels of gene were measured by real time-PCRResultsIn this study, we find that montelukast can mitigate the increase in oxidative stress and HMGB1 secretion induced by radiation, but also that montelukast exerts significant protective effects in terms of cell viability and apoptosis.ConclusionsThe authors of the present work hope to aid in the elucidation of the role of montelukast as a pretreatment for radiation and find safe and effective solutions to this common side effect of such a prevalent treatment in today’s society.

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Section: Discussionmentioning

confidence: 99%

Montelukast protects H9c2 cardiomyocytes against radiation-induced toxicity

Zhang

Zheng²,

Wang³

2021

Arch Med Sci

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“…The arrest of the lipid peroxidation process coupled with signifi-cant reductions in MDA and PC was reflected in the results of the oxidative stress markers in group D2. Klisic et al [34] calculated a novel summary score (DOI score) using markers of oxidative stress, dyslipidemia, and inflammation, and correlated that score with several diseases.…”

Section: Measurement Of Cell Death Markers In Bloodmentioning

confidence: 99%

Effect of thymoquinone on cyclophosphamide-induced injury in the rat urinary bladder

et al. 2020

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Introduction: Cyclophosphamide (CP) is a chemotherapeutic agent used to treat neoplastic diseases, but its side effects include hemorrhagic cystitis. Thymoquinone (TQ) is an active ingredient of Nigella sativa with healing potential. This study examined the protective effect of TQ against CP-induced oxidative injury in rat urinary bladder. Material and methods: Sixty rats were divided into 6 equal groups: untreated control (group A), TQ-treated with 10 mg/kg/day TQ for 10 days (group B1), TQ-treated with 100 mg/kg/day TQ for 5 days (group B2), toxicity control where 100 mg/kg CP was administered for 2 days (group C), CP + TQ-treated with the same TQ treatment as group B1 and 100 mg/kg CP for 2 days (group D1), and CP + TQ-treated with the same TQ treatment as group B2 and 100 mg/kg CP for 2 days (group D2). Rat urinary bladders were assessed histopathologically via hematoxylin and eosin (H&E) and Masson's trichrome stains and were evaluated for oxidative stress and cell death markers. Results: CP demonstrated significant reduction in glutathione reductase, and increased malondialdehyde levels and protein carbonylation (both p < 0.05). CP also induced cell death as measured by caspase-3 activation. Pretreatment with TQ (group D2) reduced CP-induced oxidative stress and apoptosis. Conclusions: TQ may ameliorate CP-induced oxidative injury in rat urinary bladder, via its antioxidant and antiapoptotic effects.

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“…Although the majority of studies reported increased prooxidant byproducts and decreased antioxidative molecules and antioxidative enzyme activities [11][12][13][14][15][16][17] in many diseases, others reported the opposite, i.e., no changes or even increased antioxidative capacity [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

Klisić

Kavarić

Vujčić

et al. 2021

Oxidative Medicine and Cellular Longevity

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Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. A total of 292 participants underwent anthropometric measurements and venipuncture procedure for cardiometabolic risk factors assessment. Waist-to-height ratio (WHtR), body mass index, visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. Principal component analysis (PCA) grouped various cardiometabolic risk parameters into different factors. This analysis was used in the subsequent binary logistic regression analysis to estimate the predictive potency of the factors towards the highest PAB and tSHG values. Our results show that triglycerides, VAI, and LAP were positively and high density lipoprotein cholesterol (HDL-c) were negatively correlated with tSHG levels and vice versa with PAB/tSHG index, respectively. On the contrary, there were no independent correlations between each cardiometabolic risk factor and PAB. PCA revealed that obesity-renal function-related factor (i.e., higher WHtR, but lower urea and creatinine) predicts both high PAB ( OR = 1.617 , 95% CI (1.204-2.171), P < 0.01 ) and low tSHG values ( OR = 0.443 , 95% CI (0.317-0.618), P < 0.001 ), while obesity-dyslipidemia-related factor (i.e., lower HDL-c and higher triglycerides, VAI, and LAP) predicts high tSHG values ( OR = 2.433 , 95% CI (1.660-3.566), P < 0.001 ). In conclusion, unfavorable cardiometabolic profile was associated with higher tSHG values. Further studies are needed to examine whether increased antioxidative capacity might be regarded as a compensatory mechanism due to free radicals’ harmful effects.

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Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes

Cited by 47 publications

References 33 publications

Montelukast protects H9c2 cardiomyocytes against radiation-induced toxicity

Montelukast protects H9c2 cardiomyocytes against radiation-induced toxicity

Effect of thymoquinone on cyclophosphamide-induced injury in the rat urinary bladder

Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

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