Endocan at the Crossroads: A Vasculoprotective Molecule or Inflammatory Marker?

Akboğa, Mehmet Kadri; Akboga, Yesim Eylev

doi:10.1177/0003319719832773

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Endothelial dysfunction is related with circulating NO-induced vasodilation in vascular diseases [39]. Endothelial dysfunction plays a role in the generation of both hypertension and aortic stiffness [40]. The relationship between serum endocan level and aortic elastic properties was assessed [41].…”

Section: Endocan and The Aortamentioning

confidence: 99%

Endocan: a new marker of endothelial function

Balta

Mikhailidis

2021

Current Opinion in Cardiology

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Purpose of reviewTo consider the role of endocan as an inflammatory marker in cardiovascular diseases. Recent findingsEndocan, an endothelial inflammatory marker, is associated with cardiovascular disease. SummaryVascular endothelial inflammation plays a key role in the pathogenesis of inflammatory and cardiovascular diseases by influencing thrombogenesis, tumour invasion and secretion of bioactive mediators. We discuss the role of endocan mainly in the context of cardiology.

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Section: Endocan and The Aortamentioning

confidence: 99%

Endocan: a new marker of endothelial function

Balta

Mikhailidis

2021

Current Opinion in Cardiology

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“…We thank Akboga and Akboga 1 for their comments on our article. 2 Our primary aim was to provide a preliminary data regarding serum endocan level in essential hypertension (EH) patients compared with healthy normotensive participants.…”

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confidence: 99%

Reply: New Insight Into the Cardiovascular Prognostic Importance of Endocan

et al. 2019

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Novel prognostic impact and cell specific role of endocan in patients with coronary artery disease

Lin,

Chang,

Leu

et al. 2024

Clin Res Cardiol

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Background Both the clinical and mechanistic impacts of endocan were not well elucidated especially in coronary artery disease (CAD). Objective This study aimed to investigate the prognostic and potential pathological role of endocan for cardiovascular (CV) events in stable CAD patients. Methods A total of 1,071 stable CAD patients with previous percutaneous coronary intervention (PCI) were enrolled prospectively in a nationwide Biosignature study. Another cohort of 76 CAD patients with or without PCI were enrolled for validation. Baseline biomarkers including endocan level was measured and total CV events especially hard CV events (including CV mortality, non-fatal myocardial infection and stroke) during follow-up were identified. Circulating endothelial progenitor cells (EPCs) as an in vivo biological contributor to vascular repairment from CAD patients were used for the in vitro functional study. Results After 24 months, there were 42 patients (3.92%) with hard CV events and 207 (19.3%) with total CV events in the study group. The incidence of both events was increased with the tertiles of baseline endocan level (hard events: 1.7%,3.4%, and 6.7% in 1st,2nd, and 3rd tertile respectively, p = 0.002; total events: 13.8%vs.16.2%vs.28.0%, p < 0.0001). Multivariate regression analysis revealed the independent association of endocan level with total and hard CV events. These findings were validated in another cohort with a 5-year follow-up. Furthermore, in vitro inhibition of endocan improved cell migration and tube formation capacities, and reduced cell adhesiveness of EPCs from CAD patients. Conclusions Endocan might be a novel prognostic indicator, mechanistic mediator, and potential therapeutic target for clinical CAD. Graphical abstract

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Endocan at the Crossroads: A Vasculoprotective Molecule or Inflammatory Marker?

Cited by 3 publications

References 11 publications

Endocan: a new marker of endothelial function

Endocan: a new marker of endothelial function

Reply: New Insight Into the Cardiovascular Prognostic Importance of Endocan

Novel prognostic impact and cell specific role of endocan in patients with coronary artery disease

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