Endocan Expression Profile in Different Grades of Oral Squamous Cell Carcinoma

Irani, Soussan; Amiri, Nasrin

doi:10.5812/ijcm.82413

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Several studies have found a significant association between endocan-MVD and tumor grade in various neoplasms. A study on 58 cases of oral squamous cell carcinoma found that a higher endocan-MVD count was seen in an intermediate and high grade of oral squamous cell carcinoma as compared to the low-grade tumor (Irani and Amiri, 2019). A study on gastric cancer also discovered a significant association of high endocan-MVD with poorly differentiated carcinomas (Chang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Endocan-microvascular Density in Primary Ovarian Carcinoma

Baba

Yajid

Nafi

et al. 2022

Asian Pac J Cancer Prev

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Background: Epithelial ovarian cancer is among the leading causes of death in women and is driven by angiogenesis. Microvascular density (MVD) can be used to evaluate angiogenesis in carcinomas and thus it can be used as a potential biomarker for ovarian cancer. This study is aimed to establish the association between endocan-MVD with clinicopathological factors in primary epithelial ovarian cancer. Methods: The clinicopathological characteristics were acquired from the medical records filed between January 2008 and December 2018 of 89 epithelial ovarian cancer cases in Hospital Universiti Sains Malaysia, Kelantan, Malaysia. Sectioned samples were analyzed for endocan through immunohistochemistry followed by the quantification of MVD. The association between clinicopathological characteristics and endocan-MVD was analyzed using the Pearson chi-square test and Fischer’s exact test. Results: All cases of epithelial ovarian carcinomas were positive for endocan. The mean ± standard deviation value of endocan-MVD level was 21.6±14.60 microvessels per 200x field. A total of 53 (59.6%) cases had low and 36 (40.04%) had high endocan-MVD values. High endocan-MVD level had a significant association with the older age group (p-value = 0.009), smaller tumor size (p-value<0.001), type II tumor (p-value<0.001), high-grade tumor (p-value<0.001), advanced FIGO stage (p-value=0.002), and presence of tumor recurrence (p-value=0.017). No significant association was found between endocan-MVD and the other clinicopathological characteristics such as race, pre-operative serum CA-125 level, presence of diabetes mellitus, endometriosis, lymph node involvement, distant metastasis, and family history of malignancy. Conclusion: Endocan-MVD showed a significant association with age, tumor size, tumor type, tumor grade, FIGO stage, and recurrence in primary epithelial ovarian cancer. Thus, endocan-MVD could be implemented as a reliable marker to predict prognosis in epithelial ovarian cancer in the future.

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Section: Discussionmentioning

confidence: 99%

Endocan-microvascular Density in Primary Ovarian Carcinoma

Baba

Yajid

Nafi

et al. 2022

Asian Pac J Cancer Prev

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“…CADM1 , a cell adhesion molecule is altered in HNSCC due to promoter hypermethylation and correlates with the poor overall survival (OS) of the patients 54 . BRCA1 / 2 , the key tumor suppressor genes exhibit varying degrees of expression in different grades of OSCC 55 56 …”

Section: Introductionmentioning

confidence: 99%

In silico interaction of HOX cluster‐embedded microRNAs and long non‐coding RNAs in oral cancer

Padam

Basavarajappa

Shenoy

et al. 2021

J Oral Pathology Medicine

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HOX genes are members of the homeotic transcription factor family, organized into four paralogous clusters. HOX complexes are believed to have arisen by genome-wide duplications during evolution. In humans, there are about 200 homeobox genes of which 39 are HOX genes, which are segregated onto four chromosomes, HOXA -7p15, HOXB -17q21.2, HOXC -12q13, and HOXD -2q31 (Figure 1). 1,2 The protein product of the HOX gene is a transcription factor that contains a conserved homeodomain region. 2 The homeodomain consists of the helix-turn-helix protein motif responsible for sequence-specific DNA binding. HOX genes are the pivotal regulators of growth and development. They regulate events such as differentiation, metabolism, apoptosis, autophagy, and their deregulation leads to various disorders and diseases including cancer. 3

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Endocan Expression Profile in Different Grades of Oral Squamous Cell Carcinoma

Cited by 2 publications

References 46 publications

Endocan-microvascular Density in Primary Ovarian Carcinoma

Endocan-microvascular Density in Primary Ovarian Carcinoma

In silico interaction of HOX cluster‐embedded microRNAs and long non‐coding RNAs in oral cancer

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