Endocannabinoid Regulation of Neuroendocrine Systems

Tasker, Jeffrey G.; Chen, Chun; Fisher, Marc O.; Fu, Xin; Rainville, Jennifer R.; Weiss, Grant L.

doi:10.1016/bs.irn.2015.09.003

Cited by 33 publications

(22 citation statements)

References 177 publications

(232 reference statements)

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“…The main structure of the reward system is the ventral striatum, which is a crucial part of the limbic loop (Abler et al, 2006). The limbic system controls the functions of the autonomic nervous system (Mujica-Parodi et al, 2009; Tavares et al, 2009) and the endocrine system (Herman et al, 2005; Krüger et al, 2015; Tasker et al, 2015). The activity of the latter influences skin conductance (Dawson et al, 2007; Zhang et al, 2016) and other physiological parameters (Wood et al, 2014; Schröder et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Pitch Syntax Violations Are Linked to Greater Skin Conductance Changes, Relative to Timbral Violations – The Predictive Role of the Reward System in Perspective of Cortico–subcortical Loops

et al. 2017

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According to contemporary opinion emotional reactions to syntactic violations are due to surprise as a result of the general mechanism of prediction. The classic view is that, the processing of musical syntax can be explained by activity of the cerebral cortex. However, some recent studies have indicated that subcortical brain structures, including those related to the processing of emotions, are also important during the processing of syntax. In order to check whether emotional reactions play a role in the processing of pitch syntax or are only the result of the general mechanism of prediction, the comparison of skin conductance levels reacting to three types of melodies were recorded. In this study, 28 subjects listened to three types of short melodies prepared in Musical Instrument Digital Interface Standard files (MIDI) – tonally correct, tonally violated (with one out-of-key – i.e., of high information content), and tonally correct but with one note played in a different timbre. The BioSemi ActiveTwo with two passive Nihon Kohden electrodes was used. Skin conductance levels were positively correlated with the presented stimuli (timbral changes and tonal violations). Although changes in skin conductance levels were also observed in response to the change in timbre, the reactions to tonal violations were significantly stronger. Therefore, despite the fact that timbral change is at least as equally unexpected as an out-of-key note, the processing of pitch syntax mainly generates increased activation of the sympathetic part of the autonomic nervous system. These results suggest that the cortico–subcortical loops (especially the anterior cingulate – limbic loop) may play an important role in the processing of musical syntax.

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Section: Introductionmentioning

confidence: 99%

Pitch Syntax Violations Are Linked to Greater Skin Conductance Changes, Relative to Timbral Violations – The Predictive Role of the Reward System in Perspective of Cortico–subcortical Loops

et al. 2017

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“…While stress response is vital to survival, prolonged stress increases the allostatic load and can have adverse effects on health [58, 59]. Interestingly, endocannabinoids play a role in allostasis, that is, they promote the recovery from stress and help to reestablish homeostasis of neurotransmitters, neurohormones, and neuropeptides [60]. This may explain the role of marijuana as a stress reliever.…”

Section: Resultsmentioning

confidence: 99%

Cannabinoid Hyperemesis

Pergolizzi Jr.,

LeQuang,

Bisney

2018

Med Cannabis Cannabinoids

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Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition in which a long-term cannabis user suffers an episode of intractable vomiting that may last days separated by longer asymptomatic periods of weeks or months. Cannabinoids are often utilized for their antiemetic properties, so CHS can be a puzzling condition, and the diagnosis of CHS may be disputed by patients. Unlike other cyclic vomiting syndromes, CHS can be relieved by hot showers or topical capsaicin. Abstinence from cannabinoids causes CHS to resolve, sometimes in a matter of days or hours. Marijuana users as well as many clinicians are not aware of CHS, and patients may undergo unnecessary tests, scans, and other procedures to get an accurate diagnosis. Symptoms may be severe enough to require hospitalization. With liberalization of marijuana laws and favorable public opinion about the healing properties of cannabis, CHS may be more frequently observed in clinical practice.

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“…Catherine Ledent (Universite Libre de Bruxelles) i Andreas Zimmer (Laboratorium Neurobiologii Molekularnej w Rheinische Friedrich-Wilhelms Universitat w Bonn) wykazali, że część efektów delta-9-THC została zniesiona u myszy pozbawionych receptora CB1 [38]. r e V i e w p a p e r Najprawdopodobniej endogenny układ kannabinoidowy bierze udział w kontroli wielu procesów fizjologicznych (udział w procesach uczenia się, zapamiętywania, przyjmowania pokarmu/stymulacji apetytu, regulacji snu, przy implantacji zarodka, hamowaniu proliferacji komórek noworodkowych, kontroli funkcji motorycznych) [40,41,42]. Razem z układem opioidowym stanowi ważny element endogennego układu obrony przed bólem [35,40].…”

Section: Receptory Kannabinoidoweunclassified

“…• Działanie przeciwnowotworowe (indukcja apoptozy, aktywacja kaskady kinaz RAF1/MAP, hamowanie cyklu komórkowego, prawdopodobna aktywacja kaskady kinaz RAF1/MAP, redukcja ekspresji receptorów dla czynników wzrostu prolaktyny i neurotrofiny, hamowanie angiogenezy i przerzutów, zmniejszenie biosyntezy proangiogennego czynnika wzrostu naczyń krwionośnych (vascular endothelial growth factor -VEGF) [3,9,10,18,24,37,39,40,42,46]. Endokannabinoidy pobudzają receptory CB1, co powoduje hamowanie uwalniania z zakończeń presynaptycznych głównie kwasu gamma-aminomasłowego lub glutaminianu [36,39,41,45].…”

Section: Tab I Preparaty Zunclassified

Cannabinoids in child neurology

Paprocka¹,

Bacler-Żbikowska²

2016

Child Neurology

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Endocannabinoid Regulation of Neuroendocrine Systems

Cited by 33 publications

References 177 publications

Pitch Syntax Violations Are Linked to Greater Skin Conductance Changes, Relative to Timbral Violations – The Predictive Role of the Reward System in Perspective of Cortico–subcortical Loops

Pitch Syntax Violations Are Linked to Greater Skin Conductance Changes, Relative to Timbral Violations – The Predictive Role of the Reward System in Perspective of Cortico–subcortical Loops

Cannabinoid Hyperemesis

Cannabinoids in child neurology

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