Endocannabinoid System and Ocular Vascularization

Iancu, Raluca; Coman, Ioana-Cristina; Barac, Cosmina; Hammoud, Mohammad Al; Popa-Cherecheanu, Alina

doi:10.3126/nepjoph.v10i2.20464

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Indeed, cannabinoid receptors have been found in and around ocular vessels, indicative of potential blood flow regulating functions. 6,[13][14][15] The effect of endogenously administered cannabinoid receptor agonists on ocular blood flow in humans is, however, only insufficiently described.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

Hommer

Schmidl

Kallab

et al. 2021

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The present study was performed to investigate the effect of oral dronabinol, a synthetic tetrahydrocannabinol derivate, on retinal hemodynamics in healthy subjects in a randomized, double-masked, placebocontrolled, 2-way crossover design. Methods: Twenty-four subjects received 5 mg dronabinol on 1 study day and placebo on the other study day. Total retinal blood flow (TRBF) was measured using a custom-built Doppler Optical Coherence Tomography system. Oxygen saturation of major retinal vessels was measured with a commercially available Dynamic Vessel Analyzer. Based on these parameters, retinal oxygen extraction was calculated. Measurements were performed before and after drug administration on both study days. Results: Placebo had no effect on TRBF, retinal arterial or venous oxygen content, and retinal oxygen extraction (P > 0.1 each). In contrast, dronabinol induced a significant increase in TRBF from 38.9 -6.1 to 40.7 -6.7 mL/min (P < 0.001), which was accompanied by a significant increase in retinal venous oxygen content (from 0.129 -0.008 to 0.132 -0.009 mL O 2 /mL, P = 0.02). As no change in retinal arterial oxygen content occurred (P = 0.12), retinal oxygen extraction remained stable (2.2 -0.4 mL vs. 2.2 -0.4 mL O 2 /min, P = 0.29). Conclusions: These results indicate that orally administered dronabinol increases TRBF in healthy subjects without altering retinal oxygen extraction. The drug may therefore be a candidate for improving perfusion in patients with ocular vascular disease.

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Section: Introductionmentioning

confidence: 99%

The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

Hommer

Schmidl

Kallab

et al. 2021

Journal of Ocular Pharmacology and Therapeutics

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“…8,11 However, the mechanisms by which eCBs produce these physiological effects are not yet elucidated. 12 Oleamide, an amide derived from oleic acid, is considered an eCB that is naturally produced in some animals. [13][14][15] The biological effects of oleamide appear to be mainly mediated by CB1 receptors, whose presence has already been demonstrated in the mesenteric arteries.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oleamide on the Vasomotor Responses in the Rat

Hernández-Díaz

Juárez-Oropeza

Mascher

et al. 2020

Cannabis and Cannabinoid Research

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Introduction: Cardiovascular effects of endocannabinoids (eCBs) have generated considerable interest since it has been suggested that the eCB system could become the new pharmacological target, either by blocking its activity or by promoting its effects on several cardiovascular diseases such as hypovolemic and septic shock or hypertension. The purpose of this study was to examine the effects of oleamide on several vasomotor responses in adult rats. Materials and Methods: Blood pressure (BP) was measured both directly and indirectly. Coronary flow was quantified with Langendorf preparation, and the vasomotor responses induced by oleamide were analyzed in the aortic rings. Results: Oleamide induced a decrease in BP, by both direct and indirect methods, which were dose dependent. An increase in coronary flow was observed with Langendorf preparation depending on the dose. Oleamide produced a vasodilator response in aortic rings pre-contracted with phenylephrine (10 À5 M), which was concentration and endothelium dependent. This relaxing effect was of minor magnitude than that induced with the same dose on BP. L-NAME did not modify these effects. However, indomethacin induced a shift to the left of the concentration-response curve to oleamide and an increase in the magnitude of maximum vasodilation in rings with endothelium. Oleamide produced the maximal relaxant response at 10 À5 M concentration. Conclusions: Oleamide has both in vivo and in vitro vasodilator effects. Vasodilator effects could be mediated by compounds synthesized/released by the endothelium (hyperpolarizing factor) or acting directly on vascular smooth muscle in aortic rings. The TRPV1 and CB1R receptors could mediate these effects. Finally, the results suggest that oleamide probably induces the synthesis/release of a vasoconstrictor prostanoid.

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Ocular Conditions and the Endocannabinoid System

John

Hausheer

2020

Cannabis in Medicine

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Endocannabinoid System and Ocular Vascularization

Cited by 3 publications

References 23 publications

The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

Effects of Oleamide on the Vasomotor Responses in the Rat

Ocular Conditions and the Endocannabinoid System

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