Endocannabinoids and pregnancy

Taylor, Anthony H.; Amoako, Akwasi; Bambang, Katerina; Karasu, Tülay; Gebeh, Alpha K.; Lam, Patricia M.W.; Marzcylo, Timothy H.; Konje, Justin C.

doi:10.1016/j.cca.2010.03.012

Cited by 74 publications

(66 citation statements)

References 192 publications

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“…30 Measurements of AEA in the blood revealed concentration variations during pregnancy. [31][32][33] In contrast to their first study, 31 Lam et al 32 showed that the AEA plasma concentrations remained unchanged during the first and second trimesters and increased during the last 3 months of pregnancy. Therefore, pregnancy seems to influence not only the glucocorticoid but also the endocannabinoid system.…”

Section: Introductionmentioning

confidence: 87%

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Krumbholz¹,

Anielski²,

Reisch

et al. 2013

Therapeutic Drug Monitoring

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Background: Endogenous corticosteroids and endocannabinoids are both known to be involved in stress adaption and anti-inflammatory and immuneregulatory effects. The application of hair as retrospective specimen for long-term recording of corticosteroids and its association with stress-induced biochemical alterations was intensively examined. Methods:To evaluate the stability and correlation of various parameters of the endocannabinoid and corticosteroid systems, a prospective study was carried out. Hair samples were collected monthly over a pregnancy cycle (sixth week of pregnancy to 9 weeks postpartum). By comparison of hair concentrations in particular segments (ie, grown in the same time span but collected at different times), an examination of analyte stability in hair was achieved. Additionally, the comparison of proximal segments provided on biochemical information that is independent of alteration due to physical instability. The detection limits of a validated procedure using solid-phase extraction cleanup and liquid chromatography-mass spectrometry proved to be suitable to identify the endogenous levels of cortisol (limits of detection = 1.6 pg/mg), cortisone (2.1 pg/mg), anandamide (AEA, 0.3 pg/mg), and 2-arachidonoylglycerol (15 pg/mg).Results: Corticosteroid concentrations in corresponding hair segments were found to be reduced with increasing hair age; an average decline of cortisol and cortisone by 50% in 4 months was estimated. Independently, an increase of cortisol and cortisone in proximal segments collected during pregnancy was confirmed, which is assumed to be stress related. Endocannabinoids proved to be by far more stable, as demonstrated by subsequent monthly collection of corresponding segments and there was hardly any washout of AEA detectable. Elevated hair concentrations of AEA and 2-arachidonoylglycerol were detected in the first-second trimester of pregnancy, which corresponds to negative correlations between AEA, cortisol, and cortisone.

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Section: Introductionmentioning

confidence: 87%

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Krumbholz¹,

Anielski²,

Reisch

et al. 2013

Therapeutic Drug Monitoring

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“…More recently, a key role for 2-AG has been proposed in the modulation of mouse spermatogenesis (Grimaldi et al, 2009). However, the molecular details of ECS elements and eCBs signalling in controlling sperm function and male fertility remain elusive (Maccarrone, 2009;Taylor et al, 2010). The aim of this study was to ascertain the presence and functionality of the main ECS elements in mouse sperm, and the possible effect of capacitation on their activity and expression.…”

Section: Introductionmentioning

confidence: 99%

Effect of capacitation on the endocannabinoid system of mouse sperm

Catanzaro

Battista

Rossi

et al. 2011

Molecular and Cellular Endocrinology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACTThe presence of the elements of the endocannabinoid system (ECS) in sperm isolated from several species (from invertebrates to mammals, humans included) has supported the "evolutionary theory" that proposes endocannabinoids as check points in reproductive events like capacitation. In this study, we characterized the ECS elements at the mRNA, protein and functional levels in mouse sperm before and after capacitation. We found that the latter process increases the endogenous levels of the two major endocannabinoids (anandamide and 2-arachidonoylglycerol), through a decreased degradation and increased biosynthesis, respectively. Additionally, we found that the binding activity of cannabinoid receptors was not affected by sperm capacitation, whereas that of vanilloid receptor was reduced. Overall, our data demonstrate that mouse sperm have a fully functional ECS, and that capacitation alters the endogenous tone of the major endocannabinoids through distinct mechanisms.

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“…Similarly, FAAH is also expressed in the stroma (Taylor et al 2010a). The expression of these two enzymes in the endometrium suggests that, during the menstrual cycle, they modulate AEA concentrations that are lower in the mid-luteal phase consistent with the idea that low levels are beneficial, and high levels detrimental, to blastocyst development , Taylor et al 2010b.…”

Section: Endocannabinoid and The Uterusmentioning

confidence: 63%

The endocannabinoid pathway and the female reproductive organs

Blasio¹,

Vignali²,

Gentilini³

2012

Journal of Molecular Endocrinology

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Endocannabinoids are endogenous ligands of cannabinoid, vanilloid and peroxisome proliferator-activated receptors that activate multiple signal transduction pathways. Together with their receptor and the enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system that has been recently shown to play, in humans, an important role in modulating several central and peripheral functions including reproduction. Given the relevance of the system, drugs that are able to interfere with the activity of endocannabinoids are currently considered as candidates for the treatment of various diseases. In this review, we will summarise the current knowledge regarding the effects of endocannabinoids in female reproductive organs. In particular, we will focus on some newly reported mechanisms that can affect endometrial plasticity both in physiological and in pathological conditions.

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Endocannabinoids and pregnancy

Cited by 74 publications

References 192 publications

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Effect of capacitation on the endocannabinoid system of mouse sperm

The endocannabinoid pathway and the female reproductive organs

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