Endocardial primary cilia and blood flow are required for regulation of EndoMT during endocardial cushion development
Kathryn Berg,
Joshua Gorham,
Faith Lundt
et al.
Abstract:Blood flow is critical for heart valve formation, and cellular mechanosensors are essential to translate flow into transcriptional regulation of development. Here, we identify a role for primary cilia in vivo in the spatial regulation of cushion formation, the first stage of valve development, by regionally controlling endothelial to mesenchymal transition (EndoMT) via modulation of Kruppel-like Factor 4 (Klf4). We find that high shear stress intracardiac regions decrease endocardial ciliation over cushion dev… Show more
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