Endocarditis trombótica no bacteriana: estudio clínico-patológico de una serie necrópsica

Llenas-García, Jara; Guerra-Vales, Juan-Manuel; Montes‐Moreno, Santiago; López‐Ríos, Fernando; Castelbón-Fernández, Francisco J.; Chimeno-García, Javier

doi:10.1016/s0300-8932(07)75066-2

Cited by 31 publications

(17 citation statements)

References 10 publications

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“…The definitive diagnosis is generally made by the demonstration of platelet thrombi at an autopsy or by surgical specimens pathologically. It has been reported that approximately 80% of NBTE cases are associated with advanced cancer (2), with autoimmune disease, tuberculosis, uremia, and acquired immune deficiency syndrome (AIDS) also reported to be the associated with NBTE (3).…”

Section: Introductionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis Concomitant with Repeated Systemic Embolization That Received Palliative Care Based on the Antemortem Diagnosis

et al. 2018

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A 67-year-old woman was admitted to our hospital due to an acute onset of consciousness disturbance, aphasia and left hemiplegia. Computed tomography revealed multiple systemic infarctions, including brain, kidney and spleen. Transesophageal echocardiography revealed vegetations attached to the mitral valve leaflets, which was suspected to be the embolic source. Repeated blood cultures were negative, and advanced lung cancer was incidentally revealed by computed tomography. She was then diagnosed with nonbacterial thrombotic endocarditis (NBTE) based on the overall clinical picture. Subsequently, extensive systemic embolization repeatedly occurred, but she eventually died 25 days after admission. The autopsy proved NBTE and advanced-stage lung adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis Concomitant with Repeated Systemic Embolization That Received Palliative Care Based on the Antemortem Diagnosis

et al. 2018

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“…En la mayoría de los casos, la muerte se produjo a consecuencia de la principal enfermedad asociada, 32% causa neoplásica, en cambio sólo 9,1% de los casos la causa de la muerte está directamente relacionada con la presencia de endocarditis marántica. Dentro de las complicaciones responsables de la muerte se puede nombrar la herniación cerebral tras embolia en el sistema nervioso central y tromboembolia pulmonar 15 . No obstante no existe mucha información acerca del pronóstico en estos pacientes ya que la mayoría de los casos reportados son hallazgos en la necropsia, en otros casos puede sub diagnosticarse y al tratarse la patología de base y se resuelven las complicaciones secundarias.…”

Section: Discussionunclassified

Endocarditis marántica como presentación de cáncer de páncreas. Caso clínico

Lanas

et al. 2017

Rev. méd. Chile

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Marantic or nonbacterial thrombotic endocarditis is characterized for the presence of vegetations formed by a meshwork of fibrin and other cellular material similar a blood clot, without the presence of microorganisms. It is often related with tumors and chronic inflammatory states. We report a 49 years old female with a history of weight loss and asthenia, presenting with multiple cerebrovascular attacks and fever. Blood cultures were negative and the fever did not subside with antibiotic treatment. Trans esophageal echocardiogram showed a mitral valve vegetation and thickening of the free edge of both leaflets. In search of the etiology of such a case, a primary pancreatic cancer with distant metastases was found. We cannot rule out the differential diagnosis with bacterial endocarditis with negative blood cultures, although the clinical context supports a non-infectious etiology.

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“…However, in three large autopsy series published over the last 30 years [6] NBTE has shown an incidence ranging between 1% and 1,6%. In these cases an underlying malignancy was found with a frequency varying between 32% and 80%.…”

Section: Discussionmentioning

confidence: 99%

“…In the great majority of these patients an embolism occur specially in the spleen, the kidneys, or the central nervous system [6] and can be the main cause of morbidity. In case of coronary embolism, if a pre-existing coronary artery disease has not led to the formation of a collateral coronary circulation, sudden disruption of the blood supply can cause more myocardial damage and a poorer prognosis, and a thrombolytic therapy could therefore seem advisable.…”

Section: Discussionmentioning

confidence: 99%

Primary Coronary Embolism as an Unusual Manifestation of Nonbacterial Thrombotic Endocarditis in a Patient with Gastric Cancer

Ferlan

Fiorella²,

Pasquale³

et al. 2010

Cardiology Research and Practice

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Nonbacterial thrombotic endocarditis (NBTE) is a rare clinical condition characterized by the presence of sterile vegetations on valvular leaflets Gross and Friedberg (1936). The most frequent cause of NBTE is antiphospholipid syndrome Hughson and et al. (1993); malignancy, through an intrinsic condition of hypercoagulability, is the second most common cause Thomas (2001). Systemic thromboembolic complications are frequently associated with this condition, but coronary embolism is not common. We report the case of a patient with NBTE secondary to gastric adenocarcinoma with clinical symptoms of coronary and systemic emboli.

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Endocarditis trombótica no bacteriana: estudio clínico-patológico de una serie necrópsica

Cited by 31 publications

References 10 publications

Nonbacterial Thrombotic Endocarditis Concomitant with Repeated Systemic Embolization That Received Palliative Care Based on the Antemortem Diagnosis

Nonbacterial Thrombotic Endocarditis Concomitant with Repeated Systemic Embolization That Received Palliative Care Based on the Antemortem Diagnosis

Endocarditis marántica como presentación de cáncer de páncreas. Caso clínico

Primary Coronary Embolism as an Unusual Manifestation of Nonbacterial Thrombotic Endocarditis in a Patient with Gastric Cancer

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