Endocarditis with Ruptured Cerebral Aneurysm Caused by
            <i>Cardiobacterium valvarum</i>
            sp. nov

Han, Xiang Y.; Meltzer, Michelle C.; Woods, Joan T.; Fainstein, Victor

doi:10.1128/jcm.42.4.1590-1595.2004

Cited by 53 publications

(64 citation statements)

References 14 publications

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“…The patient made a full recovery following aneurysm repair, antibiotic administration and aortic valve replacement. Histological analysis of the aortic root and valve showed acute and chronic inflammation (Han et al, 2004). Blood cultures became positive after an incubation period of 3 days.…”

Section: Discussionmentioning

confidence: 98%

“…Cardiobacterium valvarum is a fastidious, Gram-negative bacillus and is a member of the HACEK group [Haemophilus species, Aggregatibacter actinomycetemcomitans (formerly Actinobacillus actinomycetemcomitans), Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus and Haemophilus paraphrophilus), Cardiobacterium hominis, Eikenella corrodens and Kingella species] (Health Protection Agency, 2011). It was first identified in 2004 from the blood culture from a 37-year-old male (Han et al, 2004). The patient had presented following rupture of a mycotic cerebral aneurysm which was later found to be a complication of IE.…”

Section: Discussionmentioning

confidence: 99%

“…Blood cultures became positive after an incubation period of 3 days. Utilizing 16S rRNA gene sequencing and phylogenetic analysis, Han et al (2004) proved the organism to be unique, but most closely matched to Cardiobacterium hominis.…”

Section: Discussionmentioning

confidence: 99%

“…Although both species rarely feature as the aetiological agent of endocarditis, Cardiobacterium hominis has a higher incidence than Cardiobacterium valvarum (Han et al, 2004). Cardiobacterium valvarum is a fastidious, Gram-negative bacillus and is a member of the HACEK group [Haemophilus species, Aggregatibacter actinomycetemcomitans (formerly Actinobacillus actinomycetemcomitans), Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus and Haemophilus paraphrophilus), Cardiobacterium hominis, Eikenella corrodens and Kingella species] (Health Protection Agency, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Cerebral vasculitis and Cardiobacterium valvarum endocarditis

Abraham

Irwin

Kannappan

et al. 2012

Journal of Medical Microbiology

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We present a case of aortic and tricuspid native valve endocarditis in which Cardiobacterium valvarum was isolated from the blood culture of a 65-year-old man. Cardiobacterium valvarum is a fastidious, Gram-negative bacillus. The genus Cardiobacterium encompasses two speciesCardiobacterium valvarum and Cardiobacterium hominis. Although both species rarely feature as the aetiological agent of endocarditis, Cardiobacterium hominis has a higher incidence than Cardiobacterium valvarum. For this causative organism, we believe this is the first report of fatality prior to surgical intervention and the first clinical course to be complicated by cerebral vasculitis. Native valve endocarditis caused by Gram-negative bacilli is extremely rare and identification of isolates may require the use of reference laboratories with molecular identification techniques. Case reportA previously fit and well 65-year-old male was admitted with an 8 month history of intermittent back pain, worsening abdominal distension and non-specific symptoms of malaise, fatigue, slowed mobility and weight loss. He had not visited his general practitioner for over 30 years and had no known past medical or drug history. The patient was an occasional drinker and ex-smoker, having stopped 25 years previously. He had no history of recreational drug use. His dentition was extremely poor with widespread caries and gingivitis. He did not report any recent dental manipulation.At initial presentation, the patient had a temperature of 37.2 u C and a thin habitus and was pale. Blood pressure was 130/80 mmHg and his pulse was regular at 80 beats min 21 . On examination, a grade 4 harsh ejection systolic murmur and petechial rash over plantar areas of both feet were noted. During abdominal examination he was thought to have an expansile abdominal mass.Initial tests revealed a normal electrocardiogram and chest and abdominal radiographs. Laboratory results revealed a normocytic, normochromic anaemia [haemoglobin 10.9 g dl 21 (normal 13-18 g dl 21 ), mean corpuscular volume 92 fl (normal 76-96 fl)], total white blood cells 6.5610 9 l 21 (normal 4-11610 9 l 21 ) and normal clotting. C-reactive protein was raised at 34 mg l 21 (normal ,5) and showed an increasing trend throughout admission, peaking at 60 mg l 21 on day 13 of admission. He had renal failure with an elevated urea of 30.5 mmol l 21 (normal 2.5-6.7 mmol l 21 ), creatinine 278 mmol l 21 (normal 70-150 mmol l 21 ) and potassium 5.4 mmol l 21 (normal 3.5-5 mmol l 21 ). Sodium was 133 mmol l 21 (normal 135-145 mmol l 21 ).Urine and blood cultures were taken in the emergency department (bioMérieux BactT/Alert; aerobic and anaerobic bottles; one set of cultures). An urgent computerized tomography (CT) scan of the aorta was performed to investigate the expansile mass and lower back pain. This showed no abdominal aortic aneurysm. Incidentally, the CT scan revealed a massively dilated bladder with bilateral hydronephrosis, splenomegaly, renal cysts and pulmonary nodules with an appearance suggestive of an inflamm...

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cerebral vasculitis and Cardiobacterium valvarum endocarditis

Abraham

Irwin

Kannappan

et al. 2012

Journal of Medical Microbiology

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“…The type species of the genus Cardiobacterium, Cardiobacterium hominis, is an occasional resident of the human respiratory tract and has been associated with bacteraemia and endocarditis (Wormser & Bottone, 1983;Kiwan et al, 1989). The only other member of the genus with a validly published name, Cardiobacterium valvarum, originated from a case of human endocarditis (Han et al, 2004). The genera Dichelobacter and Suttonella include organisms previously classified as Bacteroides nodosus and Kingella indologenes, respectively (Dewhirst et al, 1990).…”

mentioning

confidence: 99%

Suttonella ornithocola sp. nov., from birds of the tit families, and emended description of the genus Suttonella

Foster¹,

Malnick

Lawson

et al. 2005

International Journal of Systematic and Evolutionary Microbiology

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Suttonella ornithocola sp. nov., from birds of the tit families, and emended description of the genus Suttonella Phenotypic and phylogenetic studies were performed on three strains of Gram-negative, rod-shaped organisms recovered from dead birds of the tit families (blue tit, coal tit and long-tailed tit). Morphological, cultural and biochemical studies indicated that the organisms were related to the family Cardiobacteriaceae in the gamma-subclass of the Proteobacteria. Comparative 16S rRNA gene sequencing studies confirmed these findings and demonstrated that the bacterium represents a hitherto unknown subline within this family. The closest phylogenetic relative of the strains isolated from the birds was found to be Suttonella indologenes, although a sequence divergence of approximately 5 % demonstrated that the unknown bacterium represented a novel species. On the basis of the results of the phylogenetic analysis and phenotypic criteria, it is proposed that the bacteria recovered from the diseased birds represent a novel species, Suttonella ornithocola sp. nov., with strain B6/99/2 T (=CCUG 49457 T =NCTC 13337 T ) as the type strain.

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Automated Blood Cultures

Han

Advanced Techniques in Diagnostic Microbiology

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Endocarditis with Ruptured Cerebral Aneurysm Caused by Cardiobacterium valvarum sp. nov

Cited by 53 publications

References 14 publications

Cerebral vasculitis and Cardiobacterium valvarum endocarditis

Cerebral vasculitis and Cardiobacterium valvarum endocarditis

Suttonella ornithocola sp. nov., from birds of the tit families, and emended description of the genus Suttonella

Automated Blood Cultures

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