Endocervical infection in a pregnant woman caused by Neisseria meningitidis: evidence of associated oropharyngeal colonization of the male partner

Harriau, P.; Ramanantsoa, Céline; Pierre, Fabrice H.F.; Riou, J.Y.; Quentin, Roland

doi:10.1016/s0301-2115(97)00098-5

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…There is also one report of mother's vaginal colonization by N. meningitidis treated with amoxicillin, and further prevention of infection transmission to the newborn; in this case report, N. meningitidis was also present in father's nasopharynx (like in our case) (“discussed by Harriau et al [9]”). Among these case reports, all had conjunctivitis, and one also developed meningitis (“discussed by Ellis et al [7]”).…”

Section: Discussionsupporting

confidence: 56%

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

Chacón-Cruz

Alvelais-Palacios

Rodriguez-Valencia

et al. 2017

Case Reports in Infectious Diseases

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Neonatal conjunctivitis is usually associated with vagina's infection by Chlamydia sp., N. gonorrhoeae, and/or other bacteria during delivery. Meningococcal neonatal conjunctivitis is an extremely rare disease. We report a case of neonatal meningococcal sepsis/conjunctivitis and asymptomatic carriage of N. meningitidis from both parents (vagina and nasopharynx). As part of our active surveillance for meningococcal disease at the Tijuana General Hospital (TGH), Mexico, we identified a 3-day-old newborn with meningococcal conjunctivitis and sepsis. The patient had a one-day history of conjunctivitis and poor feeding. Clinical examination confirmed profuse purulent conjunctival discharge, as well as clinical signs and laboratory findings suggestive of bacteraemia. Gram stain from conjunctival exudate revealed intracellular Gram negative diplococci; we presumed the baby had gonorrheal conjunctivitis; however, serogroup Y, N. meningitidis was isolated both from conjunctival exudate and blood. Additionally, isolation of serogroup Y, N. meningitidis was obtained from mother's vagina and both parents' nasopharynx. The baby was treated with 7 days of IV ceftriaxone and discharged with no sequelae.

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Section: Discussionsupporting

confidence: 56%

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

Chacón-Cruz

Alvelais-Palacios

Rodriguez-Valencia

et al. 2017

Case Reports in Infectious Diseases

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“…It can also be cultured from the subgingival tissue in individuals with both healthy and diseased gingival tissue (Hill 1998). Harriau et al (1997) described the first epidemiological study of endocervical infection and preterm delivery caused by the transfer of Neisseria meningitidis from the oralpharyngeal cavity of the male partner. This is the first documented instance of cross-colonization between sexual partners from oral-vaginal sex followed by preterm delivery.…”

Section: Infections and Behavioursmentioning

confidence: 99%

High‐risk sexual behaviours and genital infections during pregnancy

Dwyer

2001

International Nursing Review

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This article describes the sexual behaviours of some pregnant women that contribute to vaginal and cervical infections, and describes their lack of awareness about the dangers associated with sexually transmitted infections during pregnancy. It presents a subanalysis of data from a principal epidemiological study of the association between preterm delivery and genital hygiene habits and sexual behaviour during pregnancy. One-hundred and nine postpartum women were questioned about high-risk sexual behaviours during their pregnancies, their partner's sexually transmitted disease status and their knowledge about the effect of sexually transmitted infections on their pregnancy. Global concerns about the prevalence, diagnosis and treatment of cervical and vaginal infection from sexually transmitted diseases are discussed. The dangers associated with high-risk sexual behaviours during pregnancy, and recommendations for clinicians, are included.

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“…17 We identified only a few published case reports of IMD in pregnant women, with varying clinical manifestations and outcomes. Reports of acute infection include, but are not limited to, primary meningococcal pericarditis, 25 endocervicitis, 8 sepsis during labour, 26 and fulminating meningococcal septicaemia. 27 Chronic meningococcaemia has also been reported in pregnancy; 28 this is an uncommon manifestation of IMD that is associated with meningococcal lpxL1 gene mutations, 29 resulting in inactivated endotoxin.…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

“…Transmission between sexual partners during pregnancy has been reported, however: in a published case report, the partner of a woman with meningococcal endocervicitis during pregnancy had an identical strain isolated from a throat swab. 8 Having other children in the householdespecially older teenagers, who have the highest meningococcal carriage ratescould potentially be another transmission source. 32 Unfortunately, we do not have any information on the carriage status of any of the close contacts for the four cases in our cohort, who were all relatively young (age range, 21-32 years).…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

“…7 IMD in pregnancy is extremely rare, and publications are mainly restricted to individual case reports, ranging from mild infection in the mother to fatal meningococcaemia for both the mother and unborn child. 8,9 Whether pregnant women themselves are at increased risk of IMD compared with non-pregnant women is not known. A previous Dutch study reported an increased risk of meningococcal disease in children whose mothers were pregnant, 10 but a US study reported no significant difference in meningococcal carriage in relation to pregnancy status.…”

Section: Introductionmentioning

confidence: 99%

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Lower risk of invasive meningococcal disease during pregnancy: national prospective surveillance in England, 2011–2014

Parikh

Borrow

et al. 2019

BJOG

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Objective To describe cases of invasive meningococcal disease (IMD) in women of childbearing age and to estimate the disease incidence and relative risk of IMD in pregnant compared with non-pregnant women.Design Prospective enhanced national surveillance for IMD.Setting England.Population Women of reproductive age (15-44 years) with laboratory-confirmed IMD.Methods Public Health England conducts enhanced national surveillance for IMD in England. Laboratory-confirmed cases are followed up with postal questionnaires to general practitioners. All cases confirmed in women of reproductive age from 1 January 2011 to 31 December 2014 were included.Main outcome measures Annual IMD incidence and relative risk of IMD in pregnant compared with non-pregnant women of reproductive age.Results During the 4-year surveillance period, there were 1502 cases of IMD in females across England; of these, 310 (20.6%) cases were in women of reproductive age, including four women who were pregnant at the time of IMD confirmation (1.3%). Serogroup distribution of IMD cases in women of childbearing age was similar to the overall distribution. The four cases in otherwise healthy pregnant women were confirmed across all trimesters and all survived; one case in the first trimester had a septic miscarriage. The incidence of IMD was lower in pregnant than in non-pregnant women (0.16 compared with 0.76 per 100 000 pregnant and non-pregnant years, respectively), giving a lower risk of IMD in pregnant women (incidence rate ratio, IRR, 0.21; 95% confidence interval, 0.06-0.54).Conclusions Pregnant women are nearly five times less likely to develop IMD compared with non-pregnant women, but the infection can be severe.Keywords Invasive meningococcal disease, meningococcal disease, pregnancy.Tweetable abstract The risk of meningococcal disease is lower in pregnant women compared with non-pregnant women; the infection can occur across all trimesters and can be severe.

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Endocervical infection in a pregnant woman caused by Neisseria meningitidis: evidence of associated oropharyngeal colonization of the male partner

Cited by 13 publications

References 8 publications

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

High‐risk sexual behaviours and genital infections during pregnancy

Lower risk of invasive meningococcal disease during pregnancy: national prospective surveillance in England, 2011–2014

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