Endocrine abnormalities in healthy first‐degree relatives of type 2 diabetes patients – potential role of steroid hormones and leptin in the development of insulin resistance

Jansson, Per‐Anders; Eliasson, Björn; Lindmark, Stina; Eriksson, Jan W.

doi:10.1046/j.1365-2362.2002.00963.x

Cited by 23 publications

(28 citation statements)

References 46 publications

(54 reference statements)

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“…In nondiabetic, but not in type 2 diabetic subjects a strong relationship between leptin levels and insulin action on glucose uptake in subcutaneous fat cells was also found. Previous studies have shown a relationship between in vivo insulin resistance and leptin levels [28,29], and leptin has been shown to cause insulin resistance in rat fat cells in vitro [30]. Since leptin was associated with subcutaneous fat cell size as well as insulin resistance in vitro in this study, leptin may serve as a marker and possibly be a link between fat cell size and insulin resistance.…”

Section: Discussionsupporting

confidence: 56%

Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’

et al. 2007

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Aims/hypothesis The aim of this study was to explore whether fat cell size in human subcutaneous and omental adipose tissue is independently related to insulin action and adipokine levels. Materials and methods Fat cells were prepared from abdominal subcutaneous biopsies obtained from 49 type 2 diabetic and 83 non-diabetic subjects and from omental biopsies obtained from 37 non-diabetic subjects. Cell size and insulin action on glucose uptake capacity in vitro were assessed in isolated fat cells. Insulin sensitivity in vivo was assessed with euglycaemic-hyperinsulinaemic clamps. Fasting blood samples were collected and adipokines and NEFA were measured. Results Negative correlations were found between subcutaneous fat cell size and insulin sensitivity assessed as M-value during clamp and as insulin action on glucose uptake in fat cells in vitro. This was seen in non-diabetic subjects after including age, sex and BMI in the analyses. No such relationship was found in type 2 diabetic subjects. In both groups, subcutaneous fat cell size correlated positively and independently with plasma levels of leptin but not to any of the other assessed adipokines. In nondiabetic subjects, omental fat cell size was independently and negatively correlated with insulin action in subcutaneous, but not omental, fat cells in vitro.Conclusions/interpretation Fat cell enlargement is associated with insulin resistance in non-diabetic individuals independently of BMI. This was not seen in type 2 diabetic subjects, suggesting that after development of type 2 diabetes other factors, not related to fat cell size, become more important for the modulation of insulin resistance.

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Section: Discussionsupporting

confidence: 56%

Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’

et al. 2007

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“…We also suggest that high maternal visceral fat leptin expression and significantly increased fetal serum leptin levels at the time of delivery could play a role in later susceptibility to the potential post-pregnancy development of insulin resistance and T2DM in both mother and fetus (McNeely et al, 1999;Jansson et al, 2002 andShahid et al, 2008).…”

mentioning

confidence: 83%

Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Kleiblová

Dostálová

Bartlova

et al. 2010

Molecular and Cellular Endocrinology

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To cite this version:P. Kleiblova, I. Dostalova, M. Bartlova, Z. Lacinova, I. Ticha, et al.. Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Molecular and Cellular Endocrinology, Elsevier, 2009, 314 (1) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 36A c c e p t e d M a n u s c r i p t A c c e p t e d M a n u s c r i p t 2 SUMMARYThe purpose of this study was to assess the expression profile of genes with potential role in the development of insulin resistance (adipokines, cytokines/chemokines, estrogen receptors) in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placenta of pregnant women with gestational diabetes mellitus (GDM) and age-matched women with physiological pregnancy at the time of Caesarean section. qRT-PCR was used for expression analysis of the studied genes. Leptin gene expression in VAT of GDM group was significantly higher relative to control group. Gene expressions of interleukin-6 and interleukin-8 were significantly increased, whereas the expressions of genes for estrogen receptors α and β were significantly reduced in SAT of GDM group relative to controls, respectively. We found no significant differences in the expression of any genes of interest (LEP, RETN, ADIPOR1, ADIPOR2, CD68, ERα, ERβ) in placentas of women with GDM relative to controls. We conclude that increased expression of leptin in visceral adipose depot together with increased expressions of proinflammatory cytokines and reduced expressions of estrogen receptors in subcutaneous fat may play a role in the etiopathogenesis of GDM.

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“…In obese and insulin-resistant subjects and also in individuals with a genetic predisposition to type 2 diabetes mellitus, leptin levels were found to be elevated [16,20].…”

Section: Discussionmentioning

confidence: 99%

Correlation between body mass index, gender, age, family history and the prevalence of diabetes mellitus in Akwa Ibom State, Nigeria

Okon¹,

Udokang²

2017

JCLM

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Endocrine abnormalities in healthy first‐degree relatives of type 2 diabetes patients – potential role of steroid hormones and leptin in the development of insulin resistance

Abstract: Male subjects genetically predisposed for type 2 diabetes display several endocrine abnormalities including leptin, cortisol and testosterone levels. Dysregulation of these hormones may be important in the development of insulin resistance and type 2 diabetes.

Cited by 23 publications

References 46 publications

Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’

Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’

Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Correlation between body mass index, gender, age, family history and the prevalence of diabetes mellitus in Akwa Ibom State, Nigeria

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