Endocrine-active Chemicals (EACs) in Fishes

Vajda, Alan M.; Norris, David O.

doi:10.1016/b978-0-12-374932-1.00013-5

Cited by 2 publications

(2 citation statements)

References 228 publications

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“…Wastewater effluent may contain a complex chemical mixture of compounds that can influence vertebrate neural, immune and endocrine systems (Daughton & Ternes ; Vajda & Norris ). These compounds include many pharmaceuticals that enter waterways after incomplete removal during wastewater treatment (Ternes, Joss & Siegrist ).…”

Section: Introductionmentioning

confidence: 99%

An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity

Schwindt

Winkelman

Keteles

et al. 2014

Journal of Applied Ecology

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Summary1. Increased need for water and projected declines in precipitation due to climate change could leave waterways increasingly dominated by wastewater effluent. Understanding how components of wastewater influence fish populations is necessary for effective conservation and management. Despite research demonstrating effects of oestrogens, such as 17a-ethynylestradiol (EE2), on fish physiology and population failure, the generality of population responses is uncertain and the underlying mechanisms affecting population declines are unknown. EE2 is the steroid oestrogen in human contraceptive pills and has been measured up to 11 ng L À1 in the environment. 2.We identify disrupted population dynamics due to direct and transgenerational effects on survival and fecundity. We conducted a year-long study on three generations of fathead minnows Pimephales promelas Rafinesque in aquatic mesocosms and laboratory aquaria. We added environmentally relevant concentrations of EE2 daily using a static renewal, which approximates a pulsed exposure that fish experience in natural systems. 3. EE2 (3Á2 ng L À1 ) reduced F0 male survival to 17% (48% lower than controls) and juvenile production by 40% compared to controls. F1 fish continuously exposed to EE2 failed to reproduce, and reproduction of the F1 transferred to clean water was 70-99% less than controls. 4. F2 larval survival, exposed only as germ cells in their parents, was reduced by 51-97% compared to controls. The indirect effect on F2 survival suggests the possibility of transgenerational effects of EE2. 5. Synthesis and applications. Our results suggest that fish populations exposed to environmentally relevant 17a-ethynylestradiol (EE2) concentrations may not recover from exposure. Management of short-lived highly fecund fishes should be prioritized to protect fish from the embryo through gonadal differentiation. Reducing effluent will not be possible in many situations; hence, conservation of breeding and rearing habitat in unpolluted tributaries or reaches is needed. Additionally, resource managers could enhance habitat connectivity in rivers to facilitate immigration. Finally, investment in advanced wastewater processing technology should improve removal of bioactive chemicals such as EE2. Our results provide a baseline for regulatory agencies to consider when assessing the ecological effects of environmental oestrogens, and our approach to evaluating population-level effects could be widely applied to other contaminants.

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Section: Introductionmentioning

confidence: 99%

An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity

Schwindt

Winkelman

Keteles

et al. 2014

Journal of Applied Ecology

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“…Endocrine‐disrupting chemical binding to the AR can result in androgenic or antiandrogenic responses, resulting in endocrine disruption . Synthetic chemicals, including androgens and antiandrogens, are abundant worldwide in surface waters, making fish particularly susceptible to their effects . One source of androgenic EDCs is feedlot and agricultural runoff that contains excreted trenbolone metabolites .…”

Section: Introductionmentioning

confidence: 99%

Tissue explant coculture model of the hypothalamic–pituitary–gonadal–liver axis of the fathead minnow (Pimephales promelas) as a predictive tool for endocrine disruption

Johnston

Perkins

Ferguson

2016

Enviro Toxic and Chemistry

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Endocrine-disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic-pituitary-gonadal (HPG) axis. Although in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro responses to in vivo action shows inconsistent accuracy. The authors describe a tissue coculture of the fathead minnow (Pimephales promelas) HPG axis and liver (HPG-L) as a tissue explant model that mimics in vivo results. Brain (hypothalamus), pituitary, gonad, and liver tissue explants from adult fish were examined for function both individually and in coculture to determine combinations and conditions that could replicate in vivo behavior. Only cocultures had the ability to respond to an EDC, trenbolone, similarly to in vivo studies, based on estradiol, testosterone, and vitellogenin production trends, where lower exposure doses suppressed hormone production but higher doses increased production, resulting in distinctive U-shaped curves. These data suggest that a coculture system with all components of the HPG-L axis can be used as a link between in vitro and in vivo studies to predict endocrine system disruption in whole organisms. This tissue-based HPG-L system acts as a flexible deconstructed version of the in vivo system for better control and examination of the minute changes in system operation and response on EDC exposure with options to isolate, interrogate, and recombine desired components. Environ Toxicol Chem 2016;35:2530-2541. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.

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Endocrine-active Chemicals (EACs) in Fishes

Cited by 2 publications

References 228 publications

An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity

An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity

Tissue explant coculture model of the hypothalamic–pituitary–gonadal–liver axis of the fathead minnow (Pimephales promelas) as a predictive tool for endocrine disruption

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