Endocrine Alterations in the Aging Male

Elmlinger, Martin W.; Dengler, Thomas J.; Weinstock, Christoph; Kuehnel, Werner

doi:10.1515/cclm.2003.142

Cited by 35 publications

(51 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hence as with Caucasians, serum TT, DHEAS, IGF-1, IGFBP-3 and ADT declined progressively with age, SHBG, PSA and free PSA increased progressively with age while prolactin showed no appreciable change with age [11] . Furthermore, the percentage difference in the levels of the hormones between 15-to 19-year-olds compared to 70-to 79-year-olds is about the same for all parameters between Caucasians and Kuwaitis [11] . For example, in Germans, Elmlinger et al [11] showed that the difference in serum testosterone level between a 15-to 19-and 70-to 79-yearold German is about 20.9%, while in Kuwaitis it is 20.7% (p !…”

Section: Discussionmentioning

confidence: 65%

“…Furthermore, the percentage difference in the levels of the hormones between 15-to 19-year-olds compared to 70-to 79-year-olds is about the same for all parameters between Caucasians and Kuwaitis [11] . For example, in Germans, Elmlinger et al [11] showed that the difference in serum testosterone level between a 15-to 19-and 70-to 79-yearold German is about 20.9%, while in Kuwaitis it is 20.7% (p ! 0.11).…”

Section: Discussionmentioning

confidence: 77%

See 1 more Smart Citation

Reference Intervals for Important Serum Sex Steroid Hormones, Prostate-Specific Antigen, Insulin-Like Growth Factor-1 and IGF Binding Protein-3 Concentration in a Normal Kuwaiti Adult Male Population

Kehinde¹,

Akanji

Mojiminiyi

et al. 2005

Med Princ Pract

View full text Add to dashboard Cite

Objectives: The purpose of this study was to determine the age-specific reference ranges for some important male sex steroid hormones, prostate-specific antigen (PSA), insulin-like growth factor-1 (IGF-1), and IGF binding protein-3 (IGFBP-3), for the Kuwaiti population. Subjects and Methods: Blood samples were taken from 398 consenting, fasting, healthy Kuwaiti males aged 15–80 years between 8.00 a.m. and 12.00 noon. The serum concentrations of total testosterone (TT), dehydro-epiandrosterone sulfate (DHEAS), androstenedione (ADT), sex hormone binding globulin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, PSA, IGF-1 and IGFBP-3 were determined. A distribution curve was plotted and age-specific reference levels were determined for each analyte. The reference interval for parameters with a normal distribution (Gaussian) was mean ± 2 SD, while for the non-normal distribution (non-Gaussian), it was 2.5–97.5 percentile. The reference intervals for the analytes obtained from this study were compared with those suggested by the kit manufacturers and currently used by the Ministry of Health, Kuwait Laboratories (MOHKL). Results: Serum IGFBP-3 and ADT had normal distribution while other analytes had non-normal distribution. The reference intervals from this study, manufacturers kit and MOHKL were as follows: TT 3–31, 9–60, 8–35 nmol/l; DHEAS 0.9–11, 1.0–7.3, 2.2– 15.2 µmol/l; ADT 0.5–4.3, 0.8–2.8, 2.0–9.2 nmol/l; LH 1–11, 0.8–7.6, 0.4–5.7 mIU/l; FSH 0.5–11, 0.7–11.1, 1.1–13.5 mIU/l; prolactin 42–397, 53–360, 80–230 nmol/l; IGF-1 41–542, 78–956, 71–261 ng/ml; IGFBP-3 88– 2,090, 900–4,000, 900–4,000 ng/ml, and PSA 0–3.1, 0–4, 0–4 ng/ml, respectively. Conclusion: These data indicate that for Kuwaitis lower reference ranges must be used for serum TT, DHEAS, ADT, IGFBP-3 and PSA. There is no need to change the currently used reference interval for FSH whereas higher values must be used for LH, prolactin, and IGF-1.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 77%

Reference Intervals for Important Serum Sex Steroid Hormones, Prostate-Specific Antigen, Insulin-Like Growth Factor-1 and IGF Binding Protein-3 Concentration in a Normal Kuwaiti Adult Male Population

Kehinde¹,

Akanji

Mojiminiyi

et al. 2005

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…It means that the overall daily amount of hormone secretion increases. In elderly people the inhibiting effect of cortisol on the hypothalamic-pituitary axis is frequently impaired [101,102]. Diagnostic test results also show impaired cortisol suppression in response to dexametazone, as well as decreased cortisol secretion in response to ACTH [89].…”

Section: Cortisolmentioning

confidence: 99%

“…Zwiększeniu ulega więc całkowita pula wydzielania tego hormonu w ciągu doby. U osób w wieku podeszłym często dochodzi do upośledzenia hamującego działania kortyzolu na oś podwzgórzowo-przysadkową [101,102]. Stosując testy diagnostyczne stwierdzono również upośledzoną supresję kortyzolu w odpowiedzi na deksametazon, a także zmniejszone wydzielanie kortyzolu w odpowiedzi na ACTH [89].…”

Section: Kortyzolunclassified

The aging process and function of endocrine glands

Kazimierczak¹,

Nych²,

Marek³

et al. 2017

Ann. Acad. Med. Siles.

View full text Add to dashboard Cite

Population aging is becoming the biggest medical challenge of the 21st century. The body of elderly people shows a decreased ability to adapt to changing environmental and intracorporeal conditions. Aging is a process that is complex and stretches over a considerable length of time. As we get older our bodies progressively change, including the endocrine system. The changes are not unidirectional and do not affect all the endocrine glands to the same degree. The secretion of some hormones becomes impaired, while the secretion of other ones increases. There are also some hormones whose secretion does not change. The frequent concomitance of chronic diseases and taking many medications makes it difficult to interpret the results of studies on changes in hormone secretion in elderly people. This paper focuses on aging-related changes in the secretion of growth hormone, thyroid hormones, parathyroid and adrenal hormones. K E Y W O R D Saging, somatopause, thyroid hormones, parathyroid glands hormones, adrenal gland hormones ST R ES ZCZ E N IEStarzenie społeczeństw staje się największym wyzwaniem medycznym XXI w. Organizm osób w podeszłym wieku wykazuje obniżoną umiejętność przystosowywania się do zmiennych warunków środowiska zewnętrznego i wewnętrznego. Starzenie to proces złożony i znacznie rozciągnięty w czasie. Wraz z wiekiem dochodzi do postępu-jących zmian w ustroju, w tym do zmian w układzie endokrynnym. Zmiany te nie są jednokierunkowe i nie dotyczą w równym stopniu wszystkich gruczołów dokrewnych. Wydzielanie części hormonów ulega upośledzeniu, innych

show abstract

“…It is known that age-related glucose intolerance is often associated with insulin resistance (24). Furthermore, other hormones related to muscle protein turnover alter with age (25). Therefore, the physiological changes with age may influence the difference of response to myofibrillar pro tein degradation after feeding.…”

mentioning

confidence: 99%

Suppression of Myofibrillar Protein Degradation after Refeeding in Young and Adult Mice

Nagasawa

Kikuchi

Ito

et al. 2004

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryA diet containing adequate amounts of protein rapidly suppresses myofibrillar protein degradation after refeeding in young rats and mice. However, it is unclear whether this suppression is seen in adult animals. This study was undertaken to compare dietary protein-induced suppression of myofibrillar protein degradation in young and adult mice. Reductions in rates of myofibrillar protein degradation measured by NT-methylhistidine (MeHis) released from the isolated extensor digitorum longus muscle were found at 4 to 7h after refeeding in both young (7-wk-old) and adult (8-mo-old) mice, indicating that the response time of feeding-induced suppression of myofibrillar protein degradation was the same. When young (8-wk-old) mice were fed a 20% casein diet (20C) for 1h after 18h star vation, the rate of myofibrillar protein degradation was significantly decreased at 4h after refeeding; however, mice fed a 10% casein diet (10C), 5% casein diet (5C), or protein-free diet (0C) did not show suppression of myofibrillar protein degradation. Adult (8-mo-old) mice fed 20C or 10C showed a reduction in the rate of MeHis release. The plasma concen tration of leucine in young mice was only higher when they were fed 20C. Adult mice fed 20C or 10C showed higher plasma concentrations of leucine. These results suggest that postprandial suppression of myofibrillar protein degradation occurs in adult mice as in young mice, but the adult mice respond to a lower amount of dietary casein compared to the young mice. Key Words protein turnover, myofibrillar protein, dietary protein, 3-methylhistidine Aging and many catabolic diseases are accompanied by muscle wasting due to a decreased rate of synthesis and an increased rate of degradation of skeletal muscle, particularly myofibrillar protein (1-3), and these changes in synthesis and degradation accelerate fur ther catabolic disorders. It is therefore important to maintain muscle mass in aging and diseases by regulat ing the synthesis and degradation of muscle protein.Numerous studies have investigated the factors regulat ing muscle protein turnover including hormones, cytokines, and amino acids (2, 4, 5). Long-term starva tion causes loss of muscle mass by both reducing the rate of protein synthesis and increasing the rate of pro tein degradation (6). Refeeding immediately stimulates muscle protein synthesis due to the change in transla tional activity (7,8). However, the changes in the deg radation rate of muscle protein in a short period after refeeding remain to be elucidated. We have demon strated postprandial suppression of myofibrillar protein degradation in young mice and rats (8, 9), but the sup pression was not seen in rats fed a protein-free diet (8). These results suggest that dietary protein and specific amino acids are important factors in the suppression of

show abstract

Endocrine Alterations in the Aging Male

Cited by 35 publications

References 24 publications

Reference Intervals for Important Serum Sex Steroid Hormones, Prostate-Specific Antigen, Insulin-Like Growth Factor-1 and IGF Binding Protein-3 Concentration in a Normal Kuwaiti Adult Male Population

Reference Intervals for Important Serum Sex Steroid Hormones, Prostate-Specific Antigen, Insulin-Like Growth Factor-1 and IGF Binding Protein-3 Concentration in a Normal Kuwaiti Adult Male Population

The aging process and function of endocrine glands

Suppression of Myofibrillar Protein Degradation after Refeeding in Young and Adult Mice

Contact Info

Product

Resources

About