2009
DOI: 10.4314/wajm.v28i1.48415
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Endocrine and Metabolic Disorders Associated with Human Immune Deficiency Virus Infection

Abstract: RÉSUMÉ CONTEXTE: De nombreux rapports ont décrit endocriniens et métaboliques troubles dans le virus de l'immunodéficience humaine (VIH). Cet article a passé en revue différents rapports dans la littérature afin d'accroître la sensibilisation et donc la nécessité d'une intervention précoce en cas de besoin. SOURCE DES DONNÉES: Les données ont été obtenues à partir de MEDLINE, de recherche Google et d'autres revues sur le VIH, endocrinopathies / Troubles métaboliques "de 1985 à 2007. ÉTUDE DE SÉLECTION: Les étu… Show more

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Cited by 14 publications
(8 citation statements)
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References 31 publications
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“…Although the pathogenesis of NEC is unclear, multiple risk factors have been described [18,[20][21][22][23][24][25][26][27][28][29][30][31]. The immature immune function in premature neonates leads to an unbridled proinflammatory response to dietary-modulated bacterial gut adherence in the gut mucosa in NEC [63].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the pathogenesis of NEC is unclear, multiple risk factors have been described [18,[20][21][22][23][24][25][26][27][28][29][30][31]. The immature immune function in premature neonates leads to an unbridled proinflammatory response to dietary-modulated bacterial gut adherence in the gut mucosa in NEC [63].…”
Section: Discussionmentioning
confidence: 99%
“…(A) Demographics (gestational age, birth weight, sex); (B) Other known risk factors for NEC or bowel perforation (formula feeding and lack of breast milk exposure [19]; maternal syphilis [20]; weight below third centile for gestational age [21]; cardiac anomalies [22]; nonsteroidal anti-inflammatory (Nurofen) received for patent ductus arteriosus closure [23,24]; blood transfusion in previous 48 hours [25]; umbilical line placement and polycythemia [26]; multiple birth; no antenatal steroid exposure [27,28]; hypoxic events causing impaired bowel blood flow [29] including hypoxic ischemic encephalopathy; inotrope exposure preceding NEC development; maternal cocaine or methamphetamine abuse [29,30]; maternal preeclampsia/hypertension, elevated liver enzymes, low platelets; and hypogylycemic insults [31] as well as neonatal and maternal perinatal sepsis [32]); (C) Disease presentation and surrogate markers for disease severity (bacteremia detected on blood culture); radiologic markers of severe NEC, SNAPPE II, and CRIB II scores [33][34][35][36]; metabolic parameters (pH, base excess, lactate, serum sodium, hyperglycemia), hematologic (white cell, polymorph, platelet count, international normalized ratio [INR], C-reactive protein levels [37][38][39]) and hemodynamic parameters (inotrope requirements [40]); and fulminant presentation (gangrenous bowel within 24 hours of presentation) [41]; (D) Surgical findings (total gut necrosis, isolated perforation as opposed to multiple perforations [42,43]) and type of surgery done (peritoneal drains [44], primary anastomosis [45], stoma [46]). Surgery was performed either by or under the supervision of experienced pediatric surgeons according to a departmental protocol.…”
Section: Methodsmentioning
confidence: 99%
“…They did not evaluate either ETR or SVR, so that we cannot speculate about the consistency of the results with a more stringent end-point of anti-HCV therapy such as SVR. Moreover, they showed a negative correlation between protease inhibitor-based cART and RVR, indirectly confirmed by the finding of a detrimental effect of insulin resistance on HCV treatment in HIV/HCV coinfected patients [3,4]. Since in our case series as well as that of Merchante et al -both consisting mostly of patients on PI-based cART -no correlation between insulin resistance and ETR/SVR response to HCV treatment was found, even when limiting the analysis to patients assuming PI (data not shown), we therefore conclude that PI-based regimens are not responsible for the impaired response to treatment when considering more stringent end-points.…”
mentioning
confidence: 76%
“…The most common presentation of HCMV infection in HIV-infected patients is HCMV pneumonia, where co-infection with other respiratory pathogens such a tuberculosis and Pneumocystis jirovecci, is almost ubiquitous [50,60]. HCMV is an important HIV co-infection, also linked with a range diseases including meningitis [62], encephalitis [63], psychological disorders [64], malaria [65], various dermatological conditions [66,67] and those affecting mucosal epithelia [68,69], hypoadrenalism [70], adrenalitis [71], gastritis [72,73] and other herpesvirus infections [74]. There has been a huge (possibly disproportionate) focus on HCMV as a cause of HIV-associated retinitis.…”
Section: Disease Presentations and Co-morbiditymentioning
confidence: 99%