Endocrine and reproductive manifestations of sarcoidosis

SIADH as presenting feature in a male with coexisting sarcoidosis and systemic lupus

“…hypothyroidism, hypoadrenalism and hyperprolactinemia [7]. SIADH was also contributed by chronic meningitis in our patient.…”

“…Sarcoidosis can precede, follow or occur concurrently with SLE in a given patient. Abnormal CXR is seen only in 30% of neurosarcoidosis [7]. ANA positivity, cryoglobulinemia and hypergammaglobulinemia are common to both SLE and sarcoidosis, while hypocomplementemia is more commonly seen in SLE [10].…”

1,25‐dihydroxyvitamin D3 promotes IL‐10 production in human B cells

“…Patients with overproduction of calcitriol due to uncontrolled extrarenal CYP1a expression, e.g., sarcoidosis patients [31][32][33][34], suffer from peripheral immunological anergy and show enhanced numbers of Treg cells [35]. In vitro, calcitriol-stimulated dendritic cells can promote the development of Treg cells [10] and calcitriol directly enhances expression of IL-10 by Th cells [11].…”

Spontaneous Remission of Diabetes Insipidus Due to CNS Sarcoidosis

“…The incidence of sarcoidosis is 6 out of 100,000 persons, and CDI is 1 out of 25,000 persons (1,12), indicating the case of incidental development of both disorder is rare. In the cases of CDI due to sarcoidosis, the severity of pulmonary lesion tends to be mild (7). Taken together, although we have not performed pituitary biopsy, we considered that her CDI was due to CNS sarcoidosis.…”

“…The incidence is 6 out of 100,000 persons in a year, and affects mainly objects in 20s to 40s (1). About 5% of patients with sarcoidosis have central nervous system (CNS) sarcoidosis (5,6) (3,7,8).…”