Endocrine Diseases of Pregnancy

Thung, Stephen; Norwitz, Errol R.

doi:10.1016/b978-1-4160-4907-4.00026-7

Cited by 1 publication

(2 citation statements)

References 515 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a small proportion of GCs (<10%) is free and metabolically active since majority of GCs is bound to proteins during their transport in the blood. The daily production of cortisol in adults may be about 13–20 mg and may increase up to 300 mg/day [ 75 ]. In children and adolescents, the daily production of cortisol is about 6.8 mg/m 2 /day [ 45 ].…”

Section: Glucocorticoidsmentioning

confidence: 99%

“…In children and adolescents, the daily production of cortisol is about 6.8 mg/m 2 /day [ 45 ]. The plasma concentration of cortisol in adults varies in the range of 50–500 nmol/l, in the term newborns about 140 nmol/l and in premature newborns about 180 nmol/l [ 75 ]. The action of GCs contributes to the compensatory mechanisms which help the body to get a stress situation under control.…”

Section: Glucocorticoidsmentioning

confidence: 99%

See 1 more Smart Citation

Glucocorticoids in the treatment of neonatal meconium aspiration syndrome

Mokrá

Mokrý

2011

Eur J Pediatr

View full text Add to dashboard Cite

Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS.

show abstract

Section: Glucocorticoidsmentioning

confidence: 99%

Section: Glucocorticoidsmentioning

confidence: 99%