Abstract:BACKGROUND: Hodgkin’s lymphoma (HL) is one of the most common malignant lymphoproliferative diseases. Chemotherapy and radiotherapy used in the treatment of LH induce a number of toxic effects leading to dysfunction of endocrine system. Hormonal disorders in HL and their relationships with the therapy used remain to be clarified.AIM: To assess disorders of the endocrine function of thyroid, parathyroid glands and gonads in HL survivors.MATERIALS AND METHODS: Screening of endocrine dysfunction of the thyroid, p… Show more
“…Among the 15 studies, seven had fertility as primary outcome [ [23] , [24] , [25] , [28] , [29] , [31] , [34] ]. Four included both HL and NHL survivors [ [27] , [30] , [32] , [33] ], while the remaining 10 only included HL survivors [ 8 , [23] , [24] , [25] , [28] , [29] , [31] , [34] , [26] , [35] , [36] ]. One of the four studies included both curable and indolent (incurable) NHL survivors [ 32 ], two studies only curable, and one study did not specify whether indolent lymphoma survivors were included.…”
Section: Resultsmentioning
confidence: 99%
“…The other found a trend towards increased TT/SHBG ratio [ 26 ]. No obvious relationship between diagnosis or treatment and low FT was found in three studies, where one study found low FT concentrations associated to the BEACOPPe regimen [ 36 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, caution should be taken when comparing TT across different assays, because of more reliable analysis methods and assays in newer studies [ 46 ] and inter-laboratory and reference intervals differences. Furthermore, only four of 15 studies took the biologically available FT into account, by measuring SHBG in conjunction with TT [ 28 , 32 , 26 , 36 ]. All studies used different approaches; the free androgen index, the TT/SHBG ratio, FT measured by immunoassay, and one did not mention the bioavailable testosterone, but only overall SHBG concentrations, making comparison of results difficult.…”
Section: Discussionmentioning
confidence: 99%
“…In three of four studies, elevated SHBG levels were found in male lymphoma survivors, indicating that available evidence may be associated with inaccurate interpretations of hormonal status. SHBG could hypothetically be influenced after treatment due to discrete chronic damage to the liver [ 36 ] after chemotherapy or metabolic syndrome after steroid treatment. Only one study investigated the relationship between testosterone and BMI and found an association [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, Behringer et al [ 37 ] and Eeltink et al [ 41 ] found BEACOPP treated survivors were more affected than those treated with ABVD. Behringer et al [ 8 ] and Voytko et al [ 36 ] also found testosterone to be lower in BEACOPP treated survivors indicating a potential association between treatment intensity and long-term SD. However, sexual health after auto-SCT has not been found to be more severely affected than survivors treated with standard first-line treatment alone.…”
“…Among the 15 studies, seven had fertility as primary outcome [ [23] , [24] , [25] , [28] , [29] , [31] , [34] ]. Four included both HL and NHL survivors [ [27] , [30] , [32] , [33] ], while the remaining 10 only included HL survivors [ 8 , [23] , [24] , [25] , [28] , [29] , [31] , [34] , [26] , [35] , [36] ]. One of the four studies included both curable and indolent (incurable) NHL survivors [ 32 ], two studies only curable, and one study did not specify whether indolent lymphoma survivors were included.…”
Section: Resultsmentioning
confidence: 99%
“…The other found a trend towards increased TT/SHBG ratio [ 26 ]. No obvious relationship between diagnosis or treatment and low FT was found in three studies, where one study found low FT concentrations associated to the BEACOPPe regimen [ 36 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, caution should be taken when comparing TT across different assays, because of more reliable analysis methods and assays in newer studies [ 46 ] and inter-laboratory and reference intervals differences. Furthermore, only four of 15 studies took the biologically available FT into account, by measuring SHBG in conjunction with TT [ 28 , 32 , 26 , 36 ]. All studies used different approaches; the free androgen index, the TT/SHBG ratio, FT measured by immunoassay, and one did not mention the bioavailable testosterone, but only overall SHBG concentrations, making comparison of results difficult.…”
Section: Discussionmentioning
confidence: 99%
“…In three of four studies, elevated SHBG levels were found in male lymphoma survivors, indicating that available evidence may be associated with inaccurate interpretations of hormonal status. SHBG could hypothetically be influenced after treatment due to discrete chronic damage to the liver [ 36 ] after chemotherapy or metabolic syndrome after steroid treatment. Only one study investigated the relationship between testosterone and BMI and found an association [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, Behringer et al [ 37 ] and Eeltink et al [ 41 ] found BEACOPP treated survivors were more affected than those treated with ABVD. Behringer et al [ 8 ] and Voytko et al [ 36 ] also found testosterone to be lower in BEACOPP treated survivors indicating a potential association between treatment intensity and long-term SD. However, sexual health after auto-SCT has not been found to be more severely affected than survivors treated with standard first-line treatment alone.…”
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