Endocrine disrupting‐chemicals and biochemical recurrence of prostate cancer after prostatectomy: A cohort study in Guadeloupe (French West Indies)

Abstract

Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer (PCa). Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized PCa. We analyzed the relationship between exposure to the estrogenic chlordecone, the antiandrogenic dichlorodiphenyldichloroethylene (DDE, the main metabolite of the insecticide DDT), and the nondioxin‐like polychlorinated biphenyl congener 153 (PCB‐153) with mixed estrogenic/antiestrogenic properties and the risk of biochemical recurrence (BCR) after surgery. After a median follow‐up of 6.1 years after surgery, we found a significant increase in the risk of BCR, with increasing plasma chlordecone concentration (adjusted hazard ratio = 2.51; 95% confidence interval: 1.39–4.56 for the highest vs. lowest quartile of exposure; p trend = 0.002). We found no associations for DDE or PCB‐135. These results shown that exposure to environmental estrogens may negatively influence the outcome of PCa treatment.

Evidence for extensive anaerobic dechlorination and transformation of the pesticide chlordecone (C10Cl10O) by indigenous microbes in microcosms from Guadeloupe soil

“…In 2009, CLD was added to the list of persistent organic pollutants in the Stockholm Convention, banning its production and use worldwide. Studies suggest exposure to CLD may be linked to higher occurrence of prostate cancer and to impaired cognitive and motor development in young children [1,[12][13][14]. Watershed modelling predicts that CLD will remain in soils for decades or even centuries because of its stability and affinity for soil organic matter, providing a long term source of contamination to the aquatic environment [2].…”

L’agriculture biologique : controverses et enjeux globaux de développement en Afrique

“…La croissance rapide du marché mondial de produits biologiques (Willer et Lernoud, 2016) interpelle les institutions de recherche agronomique engagées dans l'accompagnement des transformations de l'agriculture dans les pays en développement. Cette croissance est nourrie par une demande de consommateurs de plus en plus sensibilisés à la qualité sanitaire (microbiologie et résidus de pesticides) des aliments (Baudry et al, 2019) et plus particulièrement aux modes de production du point de vue des produits phyto-pharmaceutiques (Bellon et Penvern, 2014 ;Brureau et al, 2019). Cette croissance répond aussi à l'exigence d'accroître la résilience des systèmes alimentaires aux différentes instabilités climatiques et politiques (Dury et al, 2019).…”

Grade groups at diagnosis in African Caribbean men with prostate cancer: Results of a comparative study

“…Regarding environmental factors, few studies have been able to focus on chlordecone, an insecticide close to DDT, yet known to be a human carcinogen . Only two solid studies have found an association between increased chlordecone plasma concentrations and the risk of PCa . More studies are requested to confirm the impact of the chlordecone on the health of Caribbean men.…”

“…32 Only two solid studies have found an association between increased chlordecone plasma concentrations and the risk of PCa. 10,33 More studies are requested to confirm the impact of the chlordecone on the health of Caribbean men.…”