Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum

Kim, KangMin; Kwon, Jin-Sook; Ahn, Changhwan; Jeung, Eui‐Bae

doi:10.3390/ijms23031581

Cited by 7 publications

(8 citation statements)

References 121 publications

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“…Accumulating evidence suggests that some endocrine disruptors induce ER stress, which might lead to apoptosis in a variety of models [27]. We measured the protein expression of two ER stress markers, namely immunoglobulin heavy chain-binding protein (BiP) and the phosphorylated form of the eukaryotic initiation factor-2α (p-eIF2α), in αTC1-9 cells treated with each of the six chemicals for 24 h. Exposure to 1 μM BPA reduced BiP expression by 45%, while no changes were observed in p-eIF2α levels (Figure 4A-C).…”

Section: Resultsmentioning

confidence: 99%

Section: Exposure To Different Mdcs Does Not Induce Er Stressmentioning

confidence: 99%

“…None of the six chemicals tested changed the expression of the activated form of eIF2α (i.e., p-eIF2α) at the doses tested. At first glance, this lack of major changes in the expression of ER stress markers may be unexpected for BPA and TBT, as these MDCs, which induce α-cell apoptosis, activate the ER stress response in other cell types[27,[51][52][53][54][55]. However, it is important to keep in mind that the expression of ER stress markers may depend on the amount and time of exposure to a given stimulus.…”

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confidence: 99%

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Screening of metabolism-disrupting chemicals on pancreatic α-cells using in vitro methods

Santos

Babiloni-Chust

Marroquí

et al. 2022

Preprint

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Metabolism-disrupting chemicals (MDCs) are endocrine disruptors with obesogenic and/or diabetogenic action. There is mounting evidence linking exposure to MDCs to increased susceptibility to diabetes. Despite the important role of glucagon in glucose homeostasis, there is little information on the effects of MDCs on alpha-cells. Furthermore, there are no methods to identify and test MDCs with the potential to alter alpha-cell viability and function. Here we used the mouse alpha-cell line alphaTC1-9 to evaluate the effects of MDCs on cell viability and glucagon secretion. We tested six chemicals at concentrations within human exposure (from 0.1 pM to 1 microM): bisphenol-A (BPA), tributyltin (TBT), perfluorooctanoic acid (PFOA), triphenylphosphate (TPP), triclosan (TCS), and dichlorodiphenyldichloroethylene (DDE). Using two different approaches, MTT assay and DNA-binding dyes, we observed that BPA and TBT decreased alpha-cell viability via a mechanism that depends on the activation of estrogen receptors and PPARgamma, respectively. These two chemicals induced ROS production, but barely altered the expression of endoplasmic reticulum (ER) stress markers. Although PFOA, TPP, TCS, and DDE did not alter cell viability nor induced ROS generation or ER stress, all four compounds negatively affected glucagon secretion. Our findings suggest that alphaTC1-9 cells seem an appropriate model to test chemicals with metabolism-disrupting activity and that the improvement of the test methods proposed herein could be incorporated into protocols for the screening of diabetogenic MDCs.

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Section: Resultsmentioning

confidence: 99%

Section: Exposure To Different Mdcs Does Not Induce Er Stressmentioning

confidence: 99%

mentioning

confidence: 99%

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Screening of metabolism-disrupting chemicals on pancreatic α-cells using in vitro methods

Santos

Babiloni-Chust

Marroquí

et al. 2022

Preprint

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“…Endoplasmic reticulum stress activates a signaling network called the unfolded protein response (UPR) to restore endoplasmic reticulum homeostasis. However, under prolonged and severe endoplasmic reticulum stress by EDCs, the UPR can become cytotoxic [ 14 , 31 ].…”

Section: Brief Properties Of Edcsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Disease Endpoints

Ahn

Jeung

2023

IJMS

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Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and have been shown to interfere with physiological systems, especially by disrupting the hormone balance. During the last few decades, EDCs have been shown to affect reproductive, neurological, and metabolic development and function and even stimulate tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals have endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates. These compounds have gradually been elucidated as risk factors for many diseases, such as reproductive, neural, and metabolic diseases and cancers. Endocrine disruption has been spread to wildlife and species that are connected to the food chains. Dietary uptake represents an important source of EDC exposure. Although EDCs represent a significant public health concern, the relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and the disease endpoints associated with endocrine disruption for a better understanding of the relationship between EDCs-disease and elucidates the development of new prevention/treatment opportunities and screening methods.

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“…Endoplasmic reticulum (ER) stress has been shown to contribute in defective spermatogenesis in both animal models and humans ( 105 ). Several studies have reported a significant increase in ROS in infertile men compared to fertile men ( 105 , 106 ).…”

Section: Physiological Effects Of Edcs On Male Infertilitymentioning

confidence: 99%

Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

Lahimer,

Abou Diwan,

Montjean

et al. 2023

Front. Public Health

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The deleterious effects of chemical or non-chemical endocrine disruptors (EDs) on male fertility potential is well documented but still not fully elucidated. For example, the detection of industrial chemicals’ metabolites in seminal plasma and follicular fluid can affect efficiency of the gametogenesis, the maturation and competency of gametes and has guided scientists to hypothesize that endocrine disrupting chemicals (EDCs) may disrupt hormonal homoeostasis by leading to a wide range of hormonal control impairments. The effects of EDCs exposure on reproductive health are highly dependent on factors including the type of EDCs, the duration of exposure, individual susceptibility, and the presence of other co-factors. Research and scientists continue to study these complex interactions. The aim of this review is to summarize the literature to better understand the potential reproductive health risks of EDCs in France.

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Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum

Cited by 7 publications

References 121 publications

Screening of metabolism-disrupting chemicals on pancreatic α-cells using in vitro methods

Screening of metabolism-disrupting chemicals on pancreatic α-cells using in vitro methods

Endocrine-Disrupting Chemicals and Disease Endpoints

Endocrine disrupting chemicals and male fertility: from physiological to molecular effects

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