Endocrine-disrupting effects of styrene oligomers that migrated from polystyrene containers into food

Date, Katsuhiro; Ohno, Katsutoshi; Azuma, Yukimasa; Hirano, Seishiro; Kobayashi, Kazuhiro; Sakurai, Takanobu; Nobuhara, Yoichi; Yamada, Toshihiro

doi:10.1016/s0278-6915(01)00096-5

Cited by 45 publications

(23 citation statements)

References 25 publications

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“…As shown here, EPS-based products release different chemicals when heated. These substances may migrate into food, and as a consequence, jeopardize the safety of these containers (Date et al, 2002). However, for many of these compounds, little is known about their health effects and most are not regulated by local authorities.…”

Section: Resultsmentioning

confidence: 99%

Identification of volatile organic compounds (VOCs) in plastic products using gas chromatography and mass spectrometry (GC/MS)

Pájaro-Castro¹,

Caballero-Gallardo²,

Olívero-Verbel³

2014

Rev. ambiente água

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Plastic materials are widely used in daily life. They contain a wide range of compounds with low molecular mass, including monomeric and oligomeric residues of polymerization, solvent-related chemicals residues, and various additives. Plastic products made of expanded polystyrene (EPS) are currently employed as food containers. This study therefore sought to identify volatile organic compounds released by EPS from food packages and utensils used in Cartagena, Colombia. EPS-based plates, food and soup containers were subjected to various temperatures and released chemicals captured by solid phase microextraction, followed by on-column thermal desorption and gas chromatography/mass spectrometry analysis. The results revealed the presence of at least 30 different compounds in the EPS-based products examined; the most frequently found were benzaldehyde, styrene, ethylbenzene and tetradecane. The release of these molecules was temperature-dependent. It is therefore advisable to regulate the use of EPS products which may be subjected to heating in order to protect human health by decreasing the exposure to these chemicals.Keywords: additives, expanded polystyrene (EPS), solid-phase microextraction (SPME), styrene. Identificação de compostos orgânicos voláteis (COVs) em produtos plásticos por cromatografia gasosa acoplada a espectrometria de massa (CG/MS) RESUMOOs materiais plásticos são amplamente usados na vida quotidiana. Eles contêm uma grande variedade de compostos de baixa massa molecular, incluindo os resíduos monoméricos e oligoméricos de polimerização, relacionados com resíduos de solventes químicos, e diferentes aditivos. Atualmente, os produtos de poliestireno expandido (EPS) são empregados como recipientes para alimentos. Assim, o objetivo deste estudo foi identificar os compostos orgânicos voláteis liberados por objetos utilizados diretamente em contato com alimentos disponíveis em Cartagena, Colômbia. Produtos baseados em EPS tais como pratos, recipientes para alimentos e sopa foram submetidos a diferentes temperaturas de aquecimento e as substâncias químicas liberadas foram capturadas empregando-se a técnica de 611 Identification of volatile organic compounds … Rev. Ambient. Água vol. 9 n. 4 Taubaté -Oct. / Dec. 2014 microextração em fase sólida, seguida de dessorção térmica e análise por cromatografia a gás/espectrometria de massa. Os resultados revelaram a presença de pelo menos 30 compostos diferentes relacionados aos produtos de EPS examinados, sendo o benzaldeído, estireno, etilbenzeno e tetradecano os mais frequentemente encontrados. A liberação dessas moléculas é dependente da temperatura a que o material é submetido. Portanto, para proteger a saúde humana, diminuindo a exposição a estes agentes químicos, é aconselhável regular o uso de produtos a base de EPS que poderão ser submetidos a aquecimento.Palavras-chave: aditivos, estireno, micro extração em fase sólida (SPME), poliestireno expandido (EPS).

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Section: Resultsmentioning

confidence: 99%

Identification of volatile organic compounds (VOCs) in plastic products using gas chromatography and mass spectrometry (GC/MS)

Pájaro-Castro¹,

Caballero-Gallardo²,

Olívero-Verbel³

2014

Rev. ambiente água

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“…The exposure levels used in these studies were 150-1500 ppm by inhalation for 5 days (Jarry et al, 2002) and 20 and 200 mg/kg bw/day s.c. for 7 days (Date et al, 2002). The Jarry et al (2002) study also found no effect of styrene exposure on hypothalamic dopamine levels.…”

Section: Or (95% Ci)mentioning

confidence: 89%

“…Date et al (2002), of Nissin Food Products Co., Japan, evaluated endocrine effects of styrene monomer (99% purity), dimer, and trimer in Sprague-Dawley and F344 rats. Estrogen-and androgen-receptor binding was assessed using receptor-rich cytosol obtained from uteri or ventral prostates of castrated 8-week-old SpragueDawley rats.…”

Section: Expert Panel Conclusionmentioning

confidence: 99%

“…Although the human data suggest effects of styrene on prolactin levels, two studies that evaluated prolactin levels in rats (Date et al, 2002;Jarry et al, 2002) failed to find any effect. The exposure levels used in these studies were 150-1500 ppm by inhalation for 5 days (Jarry et al, 2002) and 20 and 200 mg/kg bw/day s.c. for 7 days (Date et al, 2002).…”

Section: Or (95% Ci)mentioning

confidence: 99%

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NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

Luderer

Collins

Daston

et al. 2005

Birth Defects Research Pt B

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“…There are also oligomers having toxicological end points differing from those of the monomers, i.e. of fundamentally different toxicological profiles, such as the oligomers of styrene having estrogenic activity (Date et al, 2002;Ohyama, Nagai, & Tsuchiya, 2001). Obviously these are not ''covered" by the authorization of the monomer.…”

Section: Control Through Starting Substancesmentioning

confidence: 99%

Need for a better safety evaluation of food contact materials produced from resins

Grob¹,

Camus²,

Gontard

et al. 2010

Food Control

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Endocrine-disrupting effects of styrene oligomers that migrated from polystyrene containers into food

Cited by 45 publications

References 25 publications

Identification of volatile organic compounds (VOCs) in plastic products using gas chromatography and mass spectrometry (GC/MS)

Identification of volatile organic compounds (VOCs) in plastic products using gas chromatography and mass spectrometry (GC/MS)

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

Need for a better safety evaluation of food contact materials produced from resins

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