Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis

Frizzell, Caroline; Ndossi, Doreen; Verhaegen, Steven; Dahl, Ellen; Eriksen, Gunnar Sundstøl; Sørlie, Morten; Ropstad, Erik; Müller, Marc; Elliott, Christopher; Connolly, Lisa

doi:10.1016/j.toxlet.2011.07.015

Cited by 198 publications

(138 citation statements)

References 35 publications

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“…Endocrine disruptors (EDs) such as ZEN can affect the hormonal system and induce adverse effects via several mechanisms (Barton 2012, Frizzell et al 2011 by competing with endogenous oestrogens for binding sites for oestrogen receptors (ERs) or androgen receptors in female pigs, which can lead to changes in mRNA expression and protein synthesis and lower the effectiveness of endogenous steroids, (ii) by binding to the receptor without activating it -the presence of foreign substances on the receptor prevents the binding of natural hormones (antagonistic effect), (iii) by binding to transport proteins in the blood and decreasing the concentrations of natural hormones in the blood stream, (iv) by disrupting metabolic processes in the body, affecting synthesis/degradation and the release of natural hormones.…”

Section: Introductionmentioning

confidence: 99%

The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)

Zielonka¹,

Gajęcka²,

Żmudzki³

et al. 2015

Polish Journal of Veterinary Sciences

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The contamination of agricultural crops with Fusarium mycotoxins poses one of the greatest problems in food production. Wild boars live in specific habitats and are physiologically sensitive to Fusarium mycotoxins, therefore, they are an interesting model for studies investigating the effects of the discussed toxin, in particular under low-dose exposure. The objective of this study was to determine potential effects of Fusarium mycotoxins ingested with naturally contaminated food on reproductive function based on the proliferation and apoptotic indices of ovarian follicles in female wild boars. The experiment was conducted on 40 wild boars inhabiting north-eastern Poland. The effect of seasonal variations in the quantity and quality of ingested food on the concentrations of Fusarium mycotoxins and their metabolites in the blood of wild boars was analyzed. The observed differences in toxin levels were accompanied by changes in proliferation and apoptotic indices. Proliferation processes were most intense in autumn-winter and were least advanced in winter-spring. The intensity of apoptotic processes was inversely correlated with proliferation.

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Section: Introductionmentioning

confidence: 99%

The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)

Zielonka¹,

Gajęcka²,

Żmudzki³

et al. 2015

Polish Journal of Veterinary Sciences

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show abstract

“…Estrogens have lipophilic properties and therefore they easily diffuse across the lipid bilayer of the cell membrane. The mitochondria are rich in lipids and they act as the cell's estrogen reservoirs (Frizzell et al 2011).…”

Section: Introductionmentioning

confidence: 99%

The low doses effect of experimental zearalenone (ZEN) intoxication on the presence of Ca2+ in selected ovarian cells from pre-pubertal bitches

Gajęcka¹,

Przybylska‐Gornowicz²

2012

Polish Journal of Veterinary Sciences

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The objective of this study was to determine the effect of 42-day ZEN intoxication on the presence of Ca 2+ in selected ovarian cells from beagle bitches, using the potassium pyroantimonate (PPA) method. Samples were collected from 30 clinically healthy, pre-pubertal, genetically homogeneous animals. The bitches were divided into three groups of 10 animals each: experimental group I -50 μg ZEN/kg BW (100% NOAEL) administered once daily per os; experimental group II -75 μg ZEN/kg BW (150% NOAEL) administered once daily per os; control group -placebo containing no ZEN administered per os. An electron microscopic analysis revealed that cells died due to apoptosis, depending on the ZEN dose and the type of cells exposed to intoxication. Lower ZEN doses led to apoptosis-like changes in the cells. Cell death was a consequence of excess Ca 2+ accumulation in the mitochondria, followed by cell dysfunction and a decrease in or the absence of mitochondrial metabolic activity in oocytes, follicle cells and interstitial cells in experimental bitches.

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“…The results of this study were compared with the findings of experiments performed on other animals, particularly on pigs (11,14,15). The results of the study (Fig.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of the proliferative activity of immunocompetent cells in the jejunal and iliac lymph nodes of prepubertal female wild boars diagnosed with mixed mycotoxicosis

Zielonka

Jakimiuk

Obremski

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The study evaluated the proliferative activity of immunocompetent cells in the jejunal and iliac lymph nodes of prepubertal female wild boars exposed to deoxynivalenol and zearalenone in naturally contaminated feed. The evaluation was performed with the use of the MTT assay and 2 mitogens: lipopolysaccharide (LPS) and concanavalin A. Intensified proliferative processes in T and B lymphocytes were revealed. The mitogenic activity of LPS was more expressed in the lymphocytes of both iliac and jejunal lymph nodes in comparison with the control group. Proliferative activity was higher in iliac lymph nodes than in jejunal lymph nodes. A reverse trend was observed in the percentage of live cells, which was higher in jejunal lymph nodes during the evaluation of lymphocyte proliferation.

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Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis

Cited by 198 publications

References 35 publications

The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)

The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)

The low doses effect of experimental zearalenone (ZEN) intoxication on the presence of Ca2+ in selected ovarian cells from pre-pubertal bitches

Evaluation of the proliferative activity of immunocompetent cells in the jejunal and iliac lymph nodes of prepubertal female wild boars diagnosed with mixed mycotoxicosis

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