Endocrine Disruption by Mixtures in Topical Consumer Products

Abstract

Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

Sensitive Skin Syndrome and Endocrine Disruptors - Is There a Connection?

“…Caliman F. and Gavrilescu M. (2009) indicated that synthetic organic chemicals for hygienic as well as some medications such as contraceptives, antibiotics, β-blockers, and analgesics areED agents [17].The reports from other authors show EDC in pharmaceutical and personal care products [18,19].A number of substances that are included in hygiene products, cosmetics, perfumesand medicaments are listed as EDC [20,21]. Ripamonti and co-authors (2018) mentioned ethynilestradiol (used in contraceptive pills), parabens, formaldehyde, glutaraldehyde, aromatic amine derivatives, metal salts, UV filters, phthalates, solvents, fragrance ingredients and more [22]. It is true that there is still lack of information about the direct connection between EDC and skin conditions.…”

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

“…Fatoki et al (2018) corroborated the fact that livestock is a source of oestrogen in the environment. Octylphenol is used in the manufacture of detergents, (Ripamonti et al 2018). This might be the reason for its presence in the wastewaters influents.…”

Sunscreen and Suntan Preparations

“…• For a decade, Environmental Working Group (EWG) has worked to raise concerns about sunscreens with oxybenzone, which is found in nearly all Americans, detected in breast milk and potentially causing endocrine disruption [43].…”