Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products

Linares, Raquel; Fernández, Mariana F.; Gutiérrez, Ana; Garcı́a-Villalba, Rocío; Suárez, Beatriz; Zapater, Pedro; Martínez-Blázquez, J. Alberto; Caparrós, Esther; Tomás‐Barberán, Francisco A; Francés, Rubén

doi:10.1096/fj.202100481r

Cited by 24 publications

(19 citation statements)

References 62 publications

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“…A similar mechanism as described for bile acid-bound calcium phosphate particles can therefore also be applied to MNPs. Also, EDCs, especially BPA may affect gut barrier integrity, systemic inflammation, and translocation of bacterial products, as shown in rodents and patients with Crohn´s disease (Braniste et al 2010 ; Feng et al 2019 ; Linares et al 2021 ). For other EDCs insufficient evidence is available to support or refute an effect on intestinal barrier function, indicating the need for additional research efforts.…”

Section: Ingestion and Deposition Of Plastics In The Gastrointestinal...mentioning

confidence: 99%

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity

et al. 2022

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Micro- and nanoplastics (MNPs) are recognized as emerging contaminants, especially in food, with unknown health significance. MNPs passing through the gastrointestinal tract have been brought in context with disruption of the gut microbiome. Several molecular mechanisms have been described to facilitate tissue uptake of MNPs, which then are involved in local inflammatory and immune responses. Furthermore, MNPs can act as potential transporters (“vectors”) of contaminants and as chemosensitizers for toxic substances (“Trojan Horse effect”). In this review, we summarize current multidisciplinary knowledge of ingested MNPs and their potential adverse health effects. We discuss new insights into analytical and molecular modeling tools to help us better understand the local deposition and uptake of MNPs that might drive carcinogenic signaling. We present bioethical insights to basically re-consider the “culture of consumerism.” Finally, we map out prominent research questions in accordance with the Sustainable Development Goals of the United Nations.

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Section: Ingestion and Deposition Of Plastics In The Gastrointestinal...mentioning

confidence: 99%

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity

et al. 2022

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“…In general, acetate has the highest circulating level, with serum concentrations ranging from 100 to 1,000 μM, 32 , 33 , 34 whereas the concentrations of propionate and butyrate are typically <20 μM but can be elevated up to >200 μM via exogenous supplementations. 35 , 36 , 37 Intravenous infusion of sodium butyrate can raise the level even further to >500 μM without significant toxicities. 38 Although in the absence of such supplementation, baseline endogenous circulating SCFAs are less likely to provide significant fuel for the myocardium, the high affinity of SCFAs for the respective G protein–coupled receptors (GPRs) can induce pleotropic nonmetabolic effects at even these low concentrations.…”

Section: Sources and Metabolism Of Kbs And Scfasmentioning

confidence: 99%

Short-Chain Carbon Sources

Challa

Lewandowski

2022

JACC: Basic to Translational Science

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“…They also note that while some countries have taken steps to limit exposure of their population to BPA, there is still a lack of international agreement that would globally ban BPA. Finally, BPA has been reported to play a pathogenic role in Crohn’s Disease working though the microimmunosome to increase bacterial translocation and increase systemic inflammation [ 72 ].…”

Section: Public Health Failures Among Regulatory Agenciesmentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 24 publications

References 62 publications

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity

Short-Chain Carbon Sources

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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