Endocrine disruption in crustaceans: New findings and perspectives

Rodríguez, Enrique M.

doi:10.1016/j.mce.2024.112189

Cited by 2 publications

(1 citation statement)

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“…Exposure to DBP resulted in a wider set of enriched pathways such as eggshell chorion assembly (lvl 5, GO:0007306), decidualization (lvl 5, GO:0046697), and male gonad development (lvl 5, GO:0008584). Although estrogen receptor transcriptional activity has been shown to be constitutive in bivalves, there is evidence of indirect effects of estrogenic compounds on the synthesis of neurohormones (Liu et al, 2023;Rodríguez, 2024). These results suggest that reproductive output effects on exposed mussels could potentially reduce reproductive fitness, resulting in lower offspring or effects passed onto the F1 generation.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the transcriptional effects of the plastic additive dibutyl phthalate alone and in combination with microplastic on the green‐lipped mussel Perna canaliculus

Baettig,

Laroche,

Ockenden

et al. 2024

Enviro Toxic and Chemistry

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The presence and persistence of microplastics (MPs) in diverse aquatic environments are of global concern. Microplastics can impact marine organisms via direct physical interaction and the release of potentially harmful chemical additives incorporated into the plastic. These chemicals are physically bound to the plastic matrix and can leach out. The hazards associated with chemical additives to exposed organisms is not well characterized. We investigated the hazards of plastic additives leaching from plastic. We used the common plasticizer dibutyl phthalate (DBP) as a chemical additive proxy and the New Zealand green‐lipped mussel (Perna canaliculus) as a model. We used early‐adult P. canaliculus exposed to combinations of virgin and DBP‐spiked polyvinyl chloride (PVC), MPs, and DBP alone for 7 days. Whole transcriptome sequencing (RNA‐seq) was conducted to assess whether leaching of DBP from MPs poses a hazard. The differences between groups were evaluated using pairwise permutational multivariate analysis of variance (PERMANOVA), and all treatments were significantly different from controls. In addition, a significant difference was seen between DBP and PVC MP treatment. Transcriptome analysis revealed that mussels exposed to DBP alone had the most differentially expressed genes (914), followed by PVC MP + DBP (448), and PVC MP (250). Gene ontology functional analysis revealed that the most enriched pathway types were in cellular metabolism, immune response, and endocrine disruption. Microplastic treatments enriched numerous pathways related to cellular metabolism and immune response. The combined exposure of PVC MP + DBP appears to cause combined effects, suggesting that DBP is bioavailable to the exposed mussels in the PVC MP + DBP treatment. Our results support the hypothesis that chemical additives are potentially an important driver of MP toxicity. Environ Toxicol Chem 2024;00:1–11. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Section: Discussionmentioning

confidence: 99%