Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

Elobeid, Mai; Padilla, Miguel A.; Brock, David W.; Ruden, Douglas M.; Allison, David B.

doi:10.3390/ijerph7072988

Cited by 92 publications

(60 citation statements)

References 30 publications

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“…Cross-sectional [24,26,27,63] and longitudinal [23,25] studies have reported similar findings. This observation in our population is of great concern and a potential driver for obesity in this population due to the high exposure to pesticides.…”

Section: Discussionmentioning

confidence: 69%

Socio-demographic and behavioural determinants of body mass index among an adult population in rural Northern Ghana: the AWI-Gen study

Nonterah

Debpuur

Agongo

et al. 2018

Global Health Action

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Background: Obesity and associated cardiometabolic diseases are increasing in urban sub-Saharan Africa due to a complex epidemiological and nutritional transition. Related data on rural communities is scarce. Objectives: The study characterized the socio-demographic and behavioural factors influencing body mass index (BMI) among adults in rural Northern Ghana Methods: A population-based cross-sectional study involving adults aged 40–60 years residing in the Kassena-Nankana districts was undertaken. Demographic, socio-economic and behavioural data were collected along with measures of anthropometry. We determined factors associated with BMI among women and men. Results: A total of 2014 adults were studied. The median age was 51 (IQR 45–57) years and 54% were women. The prevalence of overweight/obesity was higher among women than men (18.4% vs. 7.2%; p < 0.001), whilst underweight was more prevalent in men (18.3% vs. 13.1%; p = 0.001). Participants with the highest level of education and a high household socio-economic status had higher BMIs than those in the lowest strata in both men (β = 0.074, p = 0.028 and β = 0.072, p < 0.001, respectively) and women (β = 0.174, p = 0.001 and β = 0.109, p < 0.001, respectively). Men (β = −0.050; p < 0.001) and women (β = −0.073; p < 0.001) of the Nankana ethnic group had a lower BMI than the Kassena ethnic group. Among men, alcohol consumption (β = −0.021; p = 0.001) and smoking (β = −0.216; p < 0.001) were associated with lower BMI. Smokeless tobacco was associated with lower BMI among women. Pesticide exposure was associated with higher BMI (β = 0.022; p = 0.022) among men. Conclusion: Age, sex, ethno-linguistic group and prevailing socio-demographic and behavioural factors within this rural community in Northern Ghana influence BMI. The observed positive association between pesticide use and BMI warrants further investigation.

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Section: Discussionmentioning

confidence: 69%

Socio-demographic and behavioural determinants of body mass index among an adult population in rural Northern Ghana: the AWI-Gen study

Nonterah

Debpuur

Agongo

et al. 2018

Global Health Action

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“…As a result of all the interferences caused by POPs, several changes related to appetite, food efficiency, and the ability to exercise could be observed [4].…”

Section: +mentioning

confidence: 99%

“…According to [4], the differences in the values of body mass index caused by POPs in dependence on gender remain unclear. As an example, oxychlordane is associated with BMI increase in males and decrease in females.…”

Section: +mentioning

confidence: 99%

“…Taking into consideration the reasons underlying obesity, toxic substances found in the environment and the food system have been receiving significant attention [4]. Many pollution-related risks to health are particularly high in urban areas and low-income areas, because of higher concentrations of common environmental pollutants excerting high neurological effects, such as cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), and persistent organic pollutants, i.e., polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), dichloro diphenyldichloroethylene (DDE), bisphenol A (BPA), and others.…”

mentioning

confidence: 99%

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Are Environmental Contaminants Responsible for ‘Globesity’?

Filipiak‐Florkiewicz¹,

Topolska²,

Florkiewicz³

et al. 2017

Pol. J. Environ. Stud.

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“…Exposure of zebra fish to an environmentally relevant mixture of POPs induces weight gain (10). Several prospective and cross-sectional, mostly North American, studies indicate a positive relationship between serum levels of certain POPs (mainly PCBs and OCPs) and obesity estimates such as BMI and/or waist circumference (11)(12)(13)(14).…”

mentioning

confidence: 99%

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

et al. 2014

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OBJECTIVE The contribution of persistent organic pollutants (POPs) to the pandemic of type 2 diabetes mellitus and obesity has been assumed but remains speculative. Our study aimed at investigating the relationship of POP levels with detailed markers of glucose metabolism and body composition. RESEARCH DESIGN AND METHODS Glucose tolerance was determined in a group of normal-weight and obese individuals. Fat distribution was assessed with abdominal computed tomography (CT) scanning, determining subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Selected POPs (28 polychlorinated biphenyls [PCBs] and the pesticide p,p’-dichlorodiphenyldichloroethylene [p,p’-DDE]) were measured in serum. In a subset of obese individuals undergoing bariatric surgery, POPs were also measured in adipose tissue. RESULTS Among obese participants, serum and adipose tissue levels of POPs were significantly correlated to glucose levels during an oral glucose tolerance test. Logistic regression using a model including age, age2, sex, family history of diabetes, BMI, CT-VAT, smoking behavior, physical activity level score, and a POP level identified serum levels of PCB153, the sum of PCBs and p,p’-DDE as significant predictors of abnormal glucose tolerance (odds ratio 4.6, 4.8, and 3.4, respectively; P < 0.05). Adipose tissue levels of p,p’-DDE were also significant predictors (odds ratio 81.6; P < 0.05). Serum levels of PCBs were inversely related to BMI, while serum and adipose tissue levels of all POPs were positively related to the CT-VAT/SAT ratio, suggesting an important role for the visceral fat compartment in POP dynamics. CONCLUSIONS Our findings further sustain the theory that exposure to environmentally relevant levels of POPs may exert both a diabetogenic and obesogenic effect.

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Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

Cited by 92 publications

References 30 publications

Socio-demographic and behavioural determinants of body mass index among an adult population in rural Northern Ghana: the AWI-Gen study

Socio-demographic and behavioural determinants of body mass index among an adult population in rural Northern Ghana: the AWI-Gen study

Are Environmental Contaminants Responsible for ‘Globesity’?

Exposure to Persistent Organic Pollutants: Relationship With Abnormal Glucose Metabolism and Visceral Adiposity

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