Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates

Akın, Leyla; Kendirci, Mustafa; Narin, Figen; Kurtoğlu, Selim; HATİPOĞLU>, Nihal; Elmalı, Ferhan

doi:10.4274/jcrpe.galenos.2020.2020.0037

Cited by 24 publications

(3 citation statements)

References 14 publications

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“…However, the connection between PAEs exposure and polycystic ovary syndrome (PCOS) remains controversial. Akın et al assessed the correlation between PAEs and PCOS, finding that DEHP and DBP levels were significantly higher in PCOS patients than in the control group, suggesting an association between PAEs and PCOS ( Akın et al, 2020 ). On the other hand, Akgül et al’s study found no correlation between DEHP and its metabolites in the urine of PCOS patients and the control group ( Akgül et al, 2019 ).…”

Section: Reproductive Toxicity Of Phthalic Acid Estersmentioning

confidence: 99%

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Wang,

Zhao,

Feng

et al. 2024

Front. Cell Dev. Biol.

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Recently, there has been a noticeable increase in disorders of the female reproductive system, accompanied by a rise in adverse pregnancy outcomes. This trend is increasingly being linked to environmental pollution, particularly through the lens of Endocrine Disrupting Chemicals (EDCs). These external agents disrupt natural processes of hormones, including synthesis, metabolism, secretion, transport, binding, as well as elimination. These disruptions can significantly impair human reproductive functions. A wealth of animal studies and epidemiological research indicates that exposure to toxic environmental factors can interfere with the endocrine system’s normal functioning, resulting in negative reproductive outcomes. However, the mechanisms of these adverse effects are largely unknown. This work reviews the reproductive toxicity of five major environmental EDCs—Bisphenol A (BPA), Phthalates (PAEs), Triclocarban Triclosan and Disinfection Byproducts (DBPs)—to lay a foundational theoretical basis for further toxicological study of EDCs. Additionally, it aims to spark advancements in the prevention and treatment of female reproductive toxicity caused by these chemicals.

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Section: Reproductive Toxicity Of Phthalic Acid Estersmentioning

confidence: 99%

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Wang,

Zhao,

Feng

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The TREE cohort study specifically investigated the individual and joint associations of urinary PAE metabolites with PCOS, indicating that mono (2-ethylhexyl) phthalate (MEHP), monobenzyl phthalate (MBzP), and the overall sum of DEHP were associated with a higher prevalence of PCOS ( 103 ). Furthermore, PAEs were found to be linked to metabolic disturbances, including insulin resistance indices and serum triglycerides, in adolescents with PCOS ( 104 ). However, a study evaluating DEHP and MEHP levels in adolescents found no significant differences between those with and without PCOS ( 105 ).…”

Section: Introductionmentioning

confidence: 99%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation and changes in lifestyle, the occurrence of these diseases is closely connected to exposure to harmful substances in the environment. Endocrine disrupting chemicals (EDCs), characterized by hormone-like effects, have a wide range of influences on the reproductive system. EDCs are ubiquitous in the natural environment and are present in a wide range of industrial and everyday products. Currently, thousands of chemicals have been reported to exhibit endocrine effects, and this number is likely to increase as the testing for potential EDCs has not been consistently required, and obtaining data has been limited, partly due to the long latency of many diseases. The ability to avoid exposure to EDCs, especially those of artificially synthesized origin, is increasingly challenging. While EDCs can be divided into persistent and non-persistent depending on their degree of degradation, due to the recent uptick in research studies in this area, we have chosen to focus on the research pertaining to the detrimental effects on reproductive health of exposure to several EDCs that are widely encountered in daily life over the past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, and so on. By focusing on the impact of EDCs on the hypothalamic-pituitary-gonadal (HPG) axis, which leads to the occurrence and development of reproductive system diseases, this review aims to provide new insights into the molecular mechanisms of EDCs’ damage to human health and to encourage further in-depth research to clarify the potentially harmful effects of EDC exposure through various other mechanisms. Ultimately, it offers a scientific basis to enhance EDCs risk management, an endeavor of significant scientific and societal importance for safeguarding reproductive health.

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“…Phthalates and bisphenol A (BPA) are among the chemicals used in plastic that are susceptible to leaching ( 3 ). Numerous studies have reported an association between phthalates and BPA with several adverse health conditions, such as polycystic ovarian disease ( 4 , 5 ), frequent abortion ( 6 ), obesity ( 7 ), and cancer ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Plastic use for food and drinks and related knowledge, attitudes, and practices among a sample of Egyptians

Hassan,

El Desouky,

Salem

et al. 2023

Front. Public Health

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IntroductionPlastic is extensively used in everyday life, particularly for food and beverage containers. The inappropriate use of these containers may lead to the leaching of various chemicals from plastic, such as bisphenol A, phthalate, and styrene, which cause numerous adverse health effects. This study aimed to assess the knowledge, attitudes, and practices toward using plastic for food and drinks among a sample of the Egyptian population.Materials and methodsA questionnaire was designed based on scientific literature to assess sociodemographic data, knowledge, attitudes, and practices toward the use of plastic for food and drinks. A total of 639 participants were recruited by employing the convenience sampling technique.ResultsMore than half of the participants (347, 54%) had poor knowledge scores. Personal experiences, social media, and web pages represented the most common knowledge sources. A comparison between plastic-related knowledge scores and the studied sociodemographic characteristics revealed statistically significant differences in age, gender, education, marital status, residence, working, and socioeconomic standard. A good attitude was reported by the majority (515, 80.6%) of participants. The majority (493, 77.2%) were occasional and frequent plastic users and the practice scores were significantly associated with age, education, residence, and socioeconomic standard. Higher educational level, gender (women), and rural residence were predictors of good participants knowledge, while lower socioeconomic status and urban residence were predictors of bad participants practice in a multivariate logistic regression analysis.ConclusionThe observed unsatisfactory knowledge and practice scores vs. the high attitude indicates a knowledge gap that can help direct future improvements. We call for public awareness programs about safe plastic use and the related health hazards of plastic chemicals. We also stress upon the urgent need for a collaboration between health authorities and the plastic and food industry to guarantee that information about proper plastic use is conveyed to consumers.

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Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates

Cited by 24 publications

References 14 publications

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women

The adverse role of endocrine disrupting chemicals in the reproductive system

Plastic use for food and drinks and related knowledge, attitudes, and practices among a sample of Egyptians

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