Endocrine Disruptors in the Pubertal Transition: Bisphenol A Is Negatively Correlated with Testosterone in Early Puberty

Baker, Marsha B; Hernández, Ingrid Márquez; Stanczyk, Frank Z.; Azen, Colleen; Yh, Hsu; Spruijt‐Metz, Donna

doi:10.1210/endo-meetings.2011.part4.p13.p3-722

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, two case-control studies found that women with PCOS had higher androgen and BPA levels than women without PCOS [ 7 , 24 ]. In children, there have been no reports except for an abstract from a meeting describing negative correlations of BPA with androstenedione ( ρ = −0.17, p = 0.16) and testosterone ( ρ = −0.26, p = 0.03) [ 29 ]. Unlike the study mentioned above, the results of our study support the suggested mechanism of BPA.…”

Section: Discussionmentioning

confidence: 99%

Effect of Urinary Bisphenol A on Androgenic Hormones and Insulin Resistance in Preadolescent Girls: A Pilot Study from the Ewha Birth & Growth Cohort

Lee

Kim

Lee

et al. 2013

IJERPH

View full text Add to dashboard Cite

To assess the effect of urinary bisphenol A (BPA) on repeated measurements of androgenic hormones and metabolic indices, we used multivariate analysis of variance (MANOVA) adjusted for potential confounders at baseline. During July to August 2011, 80 preadolescent girls enrolled in the Ewha Birth & Growth Cohort study participated in a follow-up study and then forty-eight of them (60.0%) came back one year later. Baseline levels of estradiol and androstenedione were higher in the BPA group than in the non-BPA group. One year later, girls in the high BPA exposure group showed higher levels of androstenedione, testosterone, estradiol, and insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index, than those in the other groups (p < 0.05). In MANOVA, estradiol and androstenedione showed significant differences among groups, while dehydroepiandrosterone, insulin, and HOMA-IR showed marginally significant differences. Exposure to BPA may affect endocrine metabolism in preadolescents. However, further investigation is required to elucidate the mechanisms linking BPA with regulation of androgenic hormones.

show abstract

Section: Discussionmentioning

confidence: 99%