Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase

Zhang, Song; Mo, Jiaying; Wang, Yiyan; Ni, Chaobo; Li, Xiaoheng; Zhu, Qiqi; Ge, Ren‐Shan

doi:10.1016/j.cbi.2019.02.027

Cited by 39 publications

(14 citation statements)

References 98 publications

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“…In male laboratory animals, phthalates interfere with sex hormone steroidogenesis in reproductive organs via alterations in steroidogenic gene transcription [205]. HSD3B, the steroidogenic enzyme that catalyzes the conversion of 3β-hydroxysteroids into 3-keto-steroids, has been identified as a phthalate target in testicular tissue [206] (Table 6).…”

Section: Non-human Animalsmentioning

confidence: 99%

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Gonsioroski

Mourikes

Flaws

2020

IJMS

213

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Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. This review discusses the occurrence of EDCs in water such as disinfection byproducts, fluorinated compounds, bisphenol A, phthalates, pesticides, and estrogens, and it outlines their adverse reproductive effects in non-human animals and humans.

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Section: Non-human Animalsmentioning

confidence: 99%

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Gonsioroski

Mourikes

Flaws

2020

IJMS

213

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“…Ketoconazole is an antifungal agent that is also able to competitively bind to the AR 193 . Ketoconazole has also been shown to inhibit enzymes important for testosterone synthesis 194 and is under investigation in combination with docetaxel (NCT00212095) 195 . In addition, TRC253, a novel competitive inhibitor of AR has been shown to be an antagonist to wildtype AR as well as all tested AR mutants 196 , including AR F877L, a mutation occurring in the LBD of AR 197 .…”

Section: Second Generation Antiandrogensmentioning

confidence: 99%

ARe we there yet? Understanding androgen receptor signaling in breast cancer

et al. 2020

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The role of androgen receptor (AR) activation and expression is well understood in prostate cancer. In breast cancer, expression and activation of AR is increasingly recognized for its role in cancer development and its importance in promoting cell growth in the presence or absence of estrogen. As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling. Targeting of the androgen receptor as a monotherapy or in combination with other conventional therapies has proven to be an effective clinical strategy for the treatment of patients with prostate cancer, and these therapeutic strategies are increasingly being investigated in breast cancer. This overlap suggests that targeting androgens and AR signaling in other cancer types may also be effective. This manuscript will review the role of AR in various cellular processes that promote tumorigenesis and metastasis, first in prostate cancer and then in breast cancer, as well as discuss ongoing efforts to target AR for the more effective treatment and prevention of cancer, especially breast cancer.

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“…CYP7B1 is present in reproductive organs and is an enzyme that metabolizes androgens ( Stiles et al, 2009 ). HSD3B1 is an important gene that catalyzes the conversion of pregnenolone to progesterone ( Zhang et al, 2019 ). Among the genes upregulated in SF, STC1 can inhibit FSH-induced progesterone production ( Luo et al, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic diversification of granulosa cells during follicular development between White Leghorn and Silky Fowl hens

et al. 2022

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Egg production rate in chicken is related to the continuity of follicle development. In this study, we found that the numbers of white prehierarchical, dominant, and yellow preovulatory follicles in the high-yielding layer breed, White Leghorn (WL), were significantly higher than those in the low egg-yielding variety, Silky Fowl (SF). The proliferation and differentiation of granulosa cells (GCs) play an important role in follicle maturation. Histological observation revealed a large number of melanocytes in the outer granulosa layer of follicles in SF but not in WL. Finally, RNA-sequencing was used to analyze the gene expression profiles and pathways of the GC layer in the follicles in both WL and SF hens. Transcriptome analysis of prehierarchical GCs (phGCs) and preovulatory GCs (poGCs) between WL and SF showed that steroid hormone-, oxytocin synthesis-, tight junction-, and endocytosis-related genes were expressed at higher levels in WL phGCs than in SF phGCs, whereas the insulin signaling pathway- and vascular smooth muscle contraction-related genes were upregulated in SF phGCs. Fatty acid synthesis, calcium signaling, and Wnt signaling pathway-related genes were expressed at higher levels in WL poGCs than in SF poGCs; however, adrenergic signaling, cGMP-PKG, and melanogenesis-related genes were upregulated in SF poGCs. These results indicate that genes that promote GC proliferation and secretion of various sex hormones are more active in WL than in SF hens. The upregulated signaling pathways in SF help in providing energy to GCs and for angiogenesis and melanogenesis. In vitro experiments confirmed that both the proliferation of poGCs and synthesis of reproductive hormones were higher in WL than in SF hens.

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Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase

Cited by 39 publications

References 98 publications

Endocrine Disruptors in Water and Their Effects on the Reproductive System

Endocrine Disruptors in Water and Their Effects on the Reproductive System

ARe we there yet? Understanding androgen receptor signaling in breast cancer

Transcriptomic diversification of granulosa cells during follicular development between White Leghorn and Silky Fowl hens

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