Endocrine effects of heat exposure and relevance to climate change

Hannan, Fadil M.; Leow, Melvin K. S.; Lee, Jason K. W.; Kovats, Sari; Elajnaf, Taha; Kennedy, Stephen H.; Thakker, Rajesh V.

doi:10.1038/s41574-024-01017-4

Nat Rev Endocrinol

2024

DOI: 10.1038/s41574-024-01017-4

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Endocrine effects of heat exposure and relevance to climate change

Fadil M. Hannan,

Melvin K. S. Leow,

Jason K. W. Lee

et al.

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2024

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Cited by 2 publications

References 114 publications

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Will Climate Change Impact Patients with Thyroid Dysfunction?

Rowe,

Talley

2024

Clinical Thyroidology®

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Will Climate Change Impact Patients with Thyroid Dysfunction?

Rowe,

Talley

2024

Clinical Thyroidology®

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Coexisting metabolic dysfunction-associated steatotic liver disease exacerbates in-hospital outcomes in patients with heat stroke

Zhang,

Tang,

Gao

et al. 2024

Front. Med.

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PurposeThis study aimed to investigate the impact of coexisting metabolic dysfunction-associated steatotic liver disease (MASLD) on in-hospital mortality and organ injury markers in patients with heat stroke (HS).ApproachHS patients were retrospectively identified between July 1, 2022 and September 30, 2023 at West China Hospital, Sichuan University. Baseline characteristics, such as demographics, initial vital signs, and organ functional indicators were collected. Outcome events included organ injury and in-hospital mortality. The Least Absolute Shrinkage and Selection Operator (Lasso) method was employed to identify the optimal predictors for in-hospital mortality in HS patients. Subsequently, multivariable logistic regression analysis was performed to assess the relationship between the presence of MASLD and in-hospital mortality as well as organ function indicators.FindingsA total of 112 patients were included in the study, in which 27 (24.1%) had coexisting MASLD. Compared to those without MASLD, patients with MASLD had higher levels of various organ injury markers such as aspartate aminotransferase, urea nitrogen, serum cystatin C, creatinine, uric acid, myoglobin, creatine kinase and its isoenzymes upon admission (P < 0.05). The multivariable Logistic regression analysis indicated that the presence of MASLD is an independent risk factor for in-hospital mortality in HS patients.ConclusionThis study firstly indicated that coexisting MASLD may exacerbate organ injury in HS patients and serve as an independent risk factor for in-hospital mortality.

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Endocrine effects of heat exposure and relevance to climate change

Cited by 2 publications

References 114 publications

Will Climate Change Impact Patients with Thyroid Dysfunction?

Will Climate Change Impact Patients with Thyroid Dysfunction?

Coexisting metabolic dysfunction-associated steatotic liver disease exacerbates in-hospital outcomes in patients with heat stroke

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