Endocrine effects of sublethal exposure to persistent organic pollutants (POPs) on silver carp (Hypophthalmichthys molitrix)

Xu, Ying; Zhang, J.; Li, W.; Schramm, K.‐W.; Kettrup, A.

doi:10.1016/s0269-7491(02)00182-3

Cited by 15 publications

(4 citation statements)

References 21 publications

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“…No other thyroidal parameters were measured. Xu et al [290] measured muscle iodine and serum total and free TH in silver carp ( Hypophthalmicthys molitrix ) sampled along a gradient of sediment contamination. They reported that the sediments contained hexachlorobenzene, PCBs, PAHs, and various TCDD‐like contaminants.…”

Section: Studies Of Thyroid Disruptionmentioning

confidence: 99%

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Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

227

139

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Abstract-Numerous environmentally relevant chemicals, including polychlorinated hydrocarbons, polycyclic aromatic hydrocarbons, organochlorine pesticides, chlorinated paraffins, organophosphorous pesticides, carbamate pesticides, cyanide compounds, methyl bromide, phenols, ammonia, metals, acid loads, sex steroids, and pharmaceuticals, exert acute or chronic effects on the thyroid cascade in the approximately 40 teleost fish species tested to date. Thyroid endpoints, therefore, serve as biomarkers of exposure to environmental pollutants. However, the mechanisms underlying thyroid changes and their physiological consequences are poorly understood because the thyroid cascade may respond indirectly and it has considerable capacity to compensate for abuses that otherwise would disrupt thyroid hormone homeostasis. Indeed, a xenobiotic-induced change in fish thyroid function has yet to be conclusively causally linked to decreased fitness or survival. Other complications in interpretation arise from the diversity of test conditions employed and the often indiscriminate use of numerous thyroid endpoints. Future work should be directed toward standardizing test conditions and thyroid endpoints and investigating causal links between thyroid changes and fish growth, reproduction, and development. Development may be particularly susceptible to thyroid disruption, and thyroid endpoints appropriate for early life stages need to be applied.

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Section: Studies Of Thyroid Disruptionmentioning

confidence: 99%

“…The fish from the most contaminated areas exhibited elevated CYP1A and UDPGT activities along with markedly depressed concentrations of FT 3 . All plasma thyroid indices were negatively correlated to the elevated hepatic CYP1A activity [290].…”

Section: Studies Of Thyroid Disruptionmentioning

confidence: 99%

Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

227

139

View full text Add to dashboard Cite

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“…Among these compounds are natural and synthetic phytoestrogen and a variety of industrial chemicals (Colburn et al, 1996;Matthiesen et al, 1996). Although the weight of evidence for human effects is minimal according to the WHO agency the International Program for Chemical Safety (IPCS, 2002), and also the EU assessment Scientific Committee on Toxicity, Ecotoxicity and the Environment (SCTEE, 1999), both field and laboratory studies have provided evidence that exposure to these chemicals can lead to the modulation or disruption of development and reproduction in aquatic life and wild life (Kavlock et al, 1996;Tyler et al, 1998;Juberg, 2000;Xu et al, 2002). In order to determine the potential exposure from estrogens in environment samples, chemical analysis is usually essential for determining the concentrations of estrogens.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

Seifert²,

et al. 2004

Environment International

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“…Several studies have demonstrated a significant increase of EROD activity for animals living in polluted sites (e.g. Xu et al 2002;Aarab et al 2004;Fasulo et al 2010).…”

Section: Erod (Ethoxyresorufin-o-deethylase) and Mt (Metallothionein)mentioning

confidence: 99%

A multibiomarker approach on the Atlantic tomcod (Microgadus tomcod) in the St. Lawrence Estuary

Dupuy

Couillard

Laroche

et al. 2012

Environ Sci Pollut Res

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A multibiomarker approach was developed on juvenile Atlantic tomcod (Microgadus tomcod) to evaluate the pertinence of this approach for low-cost screening assessment of the environmental quality of various coastal sites within estuaries. Several biometric indices and biomarkers (ethoxyresorufin-O-deethylase (EROD) activity, metallothionein concentration, and immune responses) were investigated on immature and maturing tomcods (≤ 31 months) collected in four environmentally contrasted sites in the St. Lawrence Estuary (SLE). Simultaneous examination of various age classes provides the opportunity to detect short-term responses in sensitive young-of-the-year fish (e.g., EROD induction) and longer-time effects associated with chronic exposure and bioaccumulation (e.g., metallothionein induction). Principal component analysis was helpful to discriminate between responses possibly related to contaminant exposure (EROD, metallothionein) and responses that could be affected by upstream-downstream gradient (immune response, biometric indices). Measurement of a battery of biomarkers in young tomcods at several sites along the shore of the SLE is a low-cost screening investigation useful to identify hot spots requiring further investigation with chemical analysis and additional reference sites.

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Endocrine effects of sublethal exposure to persistent organic pollutants (POPs) on silver carp (Hypophthalmichthys molitrix)

Cited by 15 publications

References 21 publications

Contaminant effects on the teleost fish thyroid

Contaminant effects on the teleost fish thyroid

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

A multibiomarker approach on the Atlantic tomcod (Microgadus tomcod) in the St. Lawrence Estuary

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