Endocrine Findings in Patients with Optico-Hypothalamic Gliomas

Martínez, Ramón Salcedo; Honegger, Jürgen; Fahlbusch, Rudolf; Buchfelder, M.

doi:10.1055/s-2003-39788

Cited by 10 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast to other suprasellar tumours, endocrine deficiencies at diagnosis are rare in OPG, particularly in the absence of hypothalamic involvement, and so this feature could be used to help differentiate OPGs from other suprasellar tumours 113,115 . Hypothalamic dysfunction is present more often in children than in adults.…”

Section: Optic Gliomamentioning

confidence: 99%

“…In addition, patients with hypothalamic disturbances, evaluated using the insulin tolerance test (ITT) and corticotrophin‐releasing hormone‐growth hormone‐releasing hormone (CRH‐GHRH) test, more often show GH and ACTH secretion deficiencies than those without. Interestingly, the peak GH using the combined CRH‐GHRH test is higher than with the ITT, suggesting that, in most patients, the functional disorder is originally hypothalamic 115 . Moreover, hypothalamic involvement is a stronger independent predictor for the development of endocrine disorders during the course of disease, and these dysfunctions evolve hierarchically over the decades.…”

Section: Optic Gliomamentioning

confidence: 99%

See 1 more Smart Citation

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

View full text Add to dashboard Cite

Many reviews have summarised the pathology and management of the parasellar region in adult patients, although an analysis of these aspects in the transition years, from puberty onset to the age of peak bone mass, has been lacking. A comprehensive search of English‐language original articles, published from 2000 to 2020, was conducted in the MEDLINE database (December 2019 to March 2020). We selected all studies regarding epidemiology, diagnosis and management of the following parasellar lesions: germinoma, craniopharyngioma, Langerhans cell histiocytosis, optic glioma, hypothalamic hamartoma, tuber cinereum hamartoma, cranial chordoma, Rathke cleft cyst, hypophysitis and hypothalamitis during the transition age from childhood to adulthood. In the present review, we provide an overview of the principal parasellar lesions occurring in the transition age. Symptoms are usually a result of the mass effect of the lesions on nearby structures, as well as anterior pituitary deficits. Diabetes insipidus occurs frequently in these patients. In this age group, pubertal developmental disorders may be more evident compared to other stages of life. Parasellar lesions in the transition age mostly include neoplastic lesions such as germinomas, hamartomas, optic gliomas, craniopharyngiomas Langerhans cell histiocytosis and chordomas, and rarely inflammatory lesions (hypophysitis, hypothalamitis). There are limited data on the management of parasellar lesions in the transition age. Endocrine evaluation is crucial for identifying conditions that require hormonal treatment so that they can be treated early to improve the quality of life of the individual patient in this complex age range. The clinical approach to parasellar lesions involves a multidisciplinary effort.

show abstract

Section: Optic Gliomamentioning

confidence: 99%

Section: Optic Gliomamentioning

confidence: 99%

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Gliomas of chiasm/hypothalamus usually do not impair the pituitary gland. Thus a diabetes insipidus or an insufficiency of the anterior pituitary lobe is usually missing in glioma patients in contrary to children with a germinoma or a Langerhans cell histiocytosis [13,21,30]. The demonstration of a normal pituitary gland before and after contrast enhancement in a non-cystic suprasellar tumor is a strong argument in favor of a glioma (Fig.…”

Section: Imaging Characteristicsmentioning

confidence: 99%

Differential Diagnosis of Suprasellar Tumors in Children

Warmuth‐Metz¹,

Gnekow²,

Müller³

et al. 2004

Klin Padiatr

View full text Add to dashboard Cite

In contrary to the adult age the most common suprasellar tumors in children are with decreasing frequency craniopharyngiomas, chiasmatic/hypothalamic low-grade gliomas, germinomas and lesions attributable to a Langerhans cell histiocytosis. For differential diagnostic purposes also the rare hypothalamic hamartoma and meningeal metastases in the infundibular recess of the third ventricle are included. The typical aspects of the various tumors on computed tomography (CT) and magnetic resonance imaging (MRI) together with important clinical differences are illustrated. On the basis of imaging results and clinical symptoms differential diagnosis between the various tumor entities should be feasible in many cases. Of course, only in strictly defined cases like typical chiasmatic/hypothalamic and optic pathway gliomas or bilocular germ cell tumors a histological confirmation is dispensable.

show abstract

MRI of the hypothalamic-pituitary axis in children

Argyropoulou

Kiortsis

2005

Pediatr Radiol

View full text Add to dashboard Cite

In childhood, the MR characteristics of the normal pituitary gland are well established. During the first 2 months of life the adenohypophysis demonstrates high signal. Pituitary gland height (PGH) decreases during the 1st year of life and then increases, reaching a plateau after puberty. The magnetization transfer ratio (MTR) increases in both sexes up to the age of 20 years. On dynamic contrast-enhanced studies, the posterior pituitary lobe enhances simultaneously with the straight sinus, and the adenohypophysis later, but within 30 s. In genetically determined dysfunctional states, the adenohypophysis may be normal, hypoplastic, or enlarged. Pituitary enlargement, observed in Prop 1 gene mutations, is characterized by a mass interposed between the anterior and posterior lobes. An ectopic posterior lobe (EPP), associated with a hypoplastic or absent pituitary stalk, may be observed in patients with hypopituitarism. Tumors of the hypothalamic-pituitary (HP) axis may be the origin of adenohypophyseal deficiencies. A small hypo-intense adenohypophysis is found in iron overload states and is often associated with hypogonadotrophic hypogonadism. Absence of the posterior lobe bright signal, with or without a thick pituitary stalk or a mass at any site from the median eminence to the posterior pituitary lobe, may be found in diabetes insipidus. Hydrocephalus, suprasellar arachnoid cysts, hypothalamic hamartomas and craniopharyngiomas may result in central precocious puberty (CPP). Increased PGH in girls with idiopathic CPP is useful for its differential diagnosis from premature thelarche (PT). Pituitary adenomas, observed mainly in adolescents, present the same MR characteristics as those in adults.

show abstract

Endocrine Findings in Patients with Optico-Hypothalamic Gliomas

Cited by 10 publications

References 11 publications

A clinical approach to parasellar lesions in the transition age

A clinical approach to parasellar lesions in the transition age

Differential Diagnosis of Suprasellar Tumors in Children

MRI of the hypothalamic-pituitary axis in children

Contact Info

Product

Resources

About