Endocrine Function with Aqueous Fruit Extract of Solanum macrocarpum Linn. In Albino Rats Chronically Administered Triton-X to Induce Hyperlipidemia

Sodipo, O. A.; Wampana, B.

doi:10.9790/3013-0230464474

Cited by 5 publications

(13 citation statements)

References 16 publications

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“…Generally, thyroid hormones are found at lower levels with a high fat diet (Williamson et al, 1996). Thyroid hormones stimulate the synthesis, mobilization and degradation of lipids, (Sodipo et al, 2012). They also lower cholesterol levels (Aliu, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Increased thyroid hormones lead to increased high density lipoprotein (HDL) which in turn leads to decreased hyperlipidaemia (Sodipo et al, 2012). Also T 3 , the active hormone, is important in hepatic degradation of cholesterol into bile acid by increasing the transcription of rate-limiting enzymes in the process, the cholesterol 9-hydroxylase (Gali, 2007;Sodipo et al, 2012). Generally, thyroid hormones are found at lower levels with a high fat diet (Williamson et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The T 3 values of hyperlipidaemic rats administered α-solanidine, NA, CT and SV were all too low to be measured whilst their T 4 values remained the same (4.00 ± 0.00. µg/dL) throughout the period of study. Increased thyroid hormones lead to increased high density lipoprotein (HDL) which in turn leads to decreased hyperlipidaemia (Sodipo et al, 2012). Also T 3 , the active hormone, is important in hepatic degradation of cholesterol into bile acid by increasing the transcription of rate-limiting enzymes in the process, the cholesterol 9-hydroxylase (Gali, 2007;Sodipo et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Sodipo et al (2012) found the levels of endocrine function indices-thyroid hormones (T 3, T 4 , TSH), reproductive hormones (testosterone and 17β oestradiol) and insulin (the pancreatic hormones) to be increased under the conditions of the study, probably contributing to the lipid lowering effect of the plant. However, the mechanism of hypolipidaemia has not been extensively studied.…”

Section: Introductionmentioning

confidence: 96%

“…Recently, hepatoprotective effect has been demonstrated with the aqueous fruit extract of S. macrocarpum in diet-induced hypercholesterolaemic rats (Sodipo et al, 2009b) and acute triton-induced hyperlipidaemic rats respectively (Sodipo et al, 2011). Sodipo et al (2012) found the levels of endocrine function indices-thyroid hormones (T 3, T 4 , TSH), reproductive hormones (testosterone and 17β oestradiol) and insulin (the pancreatic hormones) to be increased under the conditions of the study, probably contributing to the lipid lowering effect of the plant.…”

Section: Introductionmentioning

confidence: 99%

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Endocrine Function in Acute Triton-induced Hyperlipidaemic Rats after Being Administered Aqueous Fruit Extract of Solanum macrocarpum, alpha-Solanidine and Standard Hypolipidaemic Agents

Sodipo¹,

Abdulrahman²,

Sandabe³

et al. 2012

JPS

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Experimental studies were carried out on the effect of Solanum macrocarpum, α-Solanidine (a glycoalkaloid found in the Solanaceae), three antihyperlipidaemic drugs (nicotinic aid, simvastin and cholestyramine) on forty two (42) male rats made hyperlipidaemic by treating them with 400 mg/kg triton-X for 7 days. The rats were divided into 7 groups of 6 rats each. At 24 h, 48 h and 72h respectively, the rats in each group were humanely sacrificed and blood samples collected for endocrine function analysis which included thyroid hormones (thyroxine or T 4 , 3, 5, 3 -triiodothyronine or T 3 and thyroid stimulating hormone or TSH), sex hormones (testosterone and 17β oestradiol) and the pancreatic hormone, insulin. Changes in T 3 , T 4 , oestradiol, testosterone and insulin were significant (p< 0.05) throughout the period of study. There was no change in the TSH values (p> 0.05) throughout the period of study. For the extract, T 3 significantly increased (p< 0.05) from 0.60±0.14ng/mL to 0.65±0.13 ng/mL and then decreased to 0.55±0.21ng/mL at 24h, 48h and 72h respectively. For α-Solanidine and the three hypolipidaemic drugs, T 3 values were too small to be measured i.e. < 0.20 ng/mL. For the extract, T 4 significantly increased (P< 0.05) from 3.60±0.5 µg/dL to 4.30±0.43 µg/dL and then decreased to 3.80±0.28 µg/dL at 24h, 48h and 72h respectively. For α-solanidine and the three hypolipidaemic drugs, the T 4 values at 24h were 4.00±0.00 µg/dL, whilst the values remained the same at 48h and 72h i.e. there was no change. For testosterone, oestradiol and insulin, the values of the negative control were higher than those of the positive control. For the extract, the oestradiol values significantly increased (P< 0.05) from 18.00 ±4.24 pg/mL to 19.50±4.24pg/mL, then decreased to 15.04±4.24 pg/mL at 24h, 48h and 72h respectively. For α-solanidine and the three hypolipidaemic drugs, the values of oestradiol were too small to be measured i.e. < 5.00 pg/mL. For the extract, the testosterone level was 0.20±0.07 ng/mL at 24h, 0.20±0.00 ng/mL at 48h and < 0.20 mg/mL at 72h, i.e. the value could not be measured. For the other four agents, the level of testosterone was < 0.20 ng/mL i.e. too low to be measured. For the extract, the insulin values significantly decreased (p< 0.05) from 2.00±0.00 µU/mL to 1.00±0.00 µU/mL and <1.00 µU/mL (i.e. too low to be measured) at 24h, 48h and 72h respectively. On administration of α-solanidine, NA, cholestyramine and simvastatin the insulin levels remained almost constant throughout the period of study. For α-solanidine, the values were 1.50±0.00 µU/mL, 2.00±0.00 µU/mL and 2.00±0.00 µU/mL at 24h, 48h and 72h respectively. For NA, the insulin level remained at 2.00±0.00 µU/mL throughout the study period, for cholestyramine, the insulin values were 2.00±0.00 µU/mL and 1.00±0.00 µU/mL at 24h, 48h and 72h respectively whilst simvastatin had insulin values of 1.50±0.00 µU/mL, 2.00±0.00 µU/mL and 2.25±0.50 µU/mL at 24h, 48h and 72h respectively. The aqueous fruit extract of S. macrocarpum when comp...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%