Endocrine Hypertension*

Jc, Melby

doi:10.1210/jcem-69-4-697

Cited by 31 publications

(2 citation statements)

References 5 publications

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“…On the other hand, CRH stimulates the release of other POMC-derived peptides from the pituitary including a-melanocyte-stimulating hormone (MSH) (Livesey et al, 1988;Verburg-van Kemenade et al, 1987) which has been shown to stimulate aldosterone production in the zona glomerulosa (Zhu et al, 1991). In clinical studies, patients suffering from adrenal hypertension due to Conn's syndrome with mixed adenomas that secrete both aldosterone and cortisol have been described (Melby, 1989). If cells like the ones observed after stimulation of the animals in the transitional zone between zona glomerulosa and zona fasciculata also exist in human adrenals, they may form the basis of these clinicopathological observations.…”

Section: Discussionmentioning

confidence: 99%

Structure and dynamics of adrenal mitochondria following stimulation with corticotropin releasing hormone

Bornstein¹,

Ehrhart‐Bornstein²,

Güse-Behling³

et al. 1992

Anat. Rec.

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The mitochondria of rat adrenals were investigated qualitatively and quantitatively in different functional states of the adrenal cortex. Following stimulation of the animals with corticotropin releasing hormone (CRH), the corticosterone serum levels reached a maximum 1 hour after stimulation with CRH. The amount of inner mitochondrial membrane within the zona fasciculata increased showing a biphasic time course, with a first maximum 2 hours and a second maximum 8 hours after stimulation. In contrast, a significant rise of mitochondrial volume occurred only 24 hours after CRH stimulation. Therefore, the dense vesicularization of mitochondrial cristae may constitute an early process to enhance the steroidogenic capacity of these cells. Within cells of the transition zone between zona glomerulosa and zona fasciculata, we could depict a special type of mitochondria with characteristic crescent-like cristae only seen after stimulation with CRH. This type of mitochondria may represent an intermediate form between mitochondria of zona glomerulosa and zona fasciculata underlining the impressive transformational capacity of adrenocortical mitochondria. After hypophysectomy, zona fasciculata cells contained mitochondria with tubular inner membranes, representing a hypofunctional state. In contrast, the hypofunctional state after hypophysectomy and the hyperfunctional state after stimulation of the adrenal cortex via CRH injection did not appear to correlate with the morphology of mitochondria from the zona reticularis and adrenal medulla.

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Section: Discussionmentioning

confidence: 99%

Structure and dynamics of adrenal mitochondria following stimulation with corticotropin releasing hormone

Bornstein¹,

Ehrhart‐Bornstein²,

Güse-Behling³

et al. 1992

Anat. Rec.

View full text Add to dashboard Cite

show abstract

“…It cannot be assumed that pressor sensitivity to noradrenaline will be the same in Cushing's syndrome of varying aetiologies. Although features of mineralocorticoid hypertension are frequent in adrenal carcinoma ( Melby, 1989), they are absent in most patients with pituitary dependent disease, that group having normal serum potassium, total exchangeable sodium, renin and aldosterone ( Dalakos et al ., 1978 ; Ganguly et al ., 1983 ; Ritchie et al ., 1990 ), although some abnormalities in deoxycorticosterone (DOC) and 19‐nor‐DOC has been reported ( Melby, 1989). In addition a recent study suggested that reduced 11 beta‐hydroxysteroid dehydrogenase activity may play a role in the hypertension of Cushing's syndrome of different aetiologies (Stewart et al ., 1985), but the extent of the abnormality of cortisol metabolism was variable, being most marked in patients with ectopic ACTH syndrome.…”

Section: Discussionmentioning

confidence: 99%