Endocrine Hypertension in Small Animals

Reusch, Claudia E; Schellenberg, Stefan; Wenger, M.

doi:10.1016/j.cvsm.2009.10.005

Cited by 43 publications

(40 citation statements)

References 89 publications

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“…In one study, two diabetic cats with hypertensive retinopathy were described; one had evidence of renal dysfunction, which may have been the cause of hypertension, but the other cat had no other concurrent disease (Maggio et al, 2000). Further studies using larger cohorts of diabetic cats are needed to evaluate questions, such as the definitive prevalence of hypertension and the risk of kidney-damage when blood pressure is in the upper end of normal (Reusch et al, 2010).…”

Section: Systemic Hypertensionmentioning

confidence: 97%

“…In some countries (e.g., Australia, New Zealand, and the United Kingdom), the Burmese breed has been shown to be at increased risk (Wade et al, 1999;McCann et al, 2007;Lederer et al, 2009), whereas this risk seems not to be present in breeding lines of other countries. In our own population of diabetic cats, approximately 50% to 60% are overweight, 30% to 40% are normal weight, and 5% to 10% are underweight (Reusch, 2010 …”

Section: Signalmentmentioning

confidence: 98%

“…Generation of one or several BGCs and revision of the owner's injection technique are usually the next steps in those cases. Fructosamine concentrations less than 350 μmol/L suggest diabetic remission, hypoglycemia or concurrent hypoproteinemia, or hyperthyroidism (Reusch, 2010). It is important to note that there are substantial differences in glycation between individuals.…”

Section: Serum Fructosamine Concentrationmentioning

confidence: 99%

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Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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Section: Systemic Hypertensionmentioning

confidence: 97%

Section: Signalmentmentioning

confidence: 98%

Section: Serum Fructosamine Concentrationmentioning

confidence: 99%

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Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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“…Hypertension could contribute to progression of renal damage, causing glomerulosclerosis as proteinuria and glomerular disease may occur in the majority of dogs with chronic kidney disease and systemic hypertension (Schellenberg et al 2008, Bacic et al 2010, Reusch et al 2010.…”

Section: Discussionmentioning

confidence: 99%

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

et al. 2017

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RESUMO.-[Avaliação da proteína urinária por eletroforese em cães com hiperadrenocorticismo hipófise dependente durante a terapia com trilostano.] Hiperadrenocorticismo (HAC) é uma das doenças endócrinas mais comuns em cães. A hipercortisolemia crônica pode causar danos glomerulares, pelo aumento da taxa de filtração glomerular, podendo levar ao desenvolvimento de doença renal crônica. Este estudo avaliou nove cães normotensos com hiperadrenocorticismo hipófise-dependente, antes e após a terapia com trilostano, durante o período de acompanhamento de seis meses, a fim de investigar o desenvolvimento de proteinúria patológica por métodos quantitativo (relação proteína e creatinina urinária) e qualitativos (eletroforese de proteínas urinárias) e também para monitorar a sua intensidade ao longo do curso da doença e terapia. A principal lesão renal detectada em cães com HAC foi no segmento tubular, evidenciada pela prevalência de bandas de proteínas urinárias de peso molecular mais baixo, indicando a falta de absorção destas proteínas no segmento proximal do néfron. A proteinúria de baixo peso molecular persistiu durante todo o acompanhamento. Em relação ao futuro da rotina clínica médica veterinária no tratamento de cães com hiperadrenocorticismo, as avaliações de proteinúria pela relação proteína e creatinina urinária e eletro- Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis. 735 Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane forese de proteínas urinárias, de acordo com os resultados obtidos neste estudo, podem adicionar mais informações sobre a lesão renal nestes animais e contribuir para o prognóstico.

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“…The reason for these differences was probably the inclusion and exclusion factors of the studies. In the dogs included in this study there were no changes in target organs, secondary to SAH [21].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Parameters in Obese Dogs Undergoing to the Diet with Calorie Restriction

Marchi¹,

Cardoso²,

Fagnani³

et al. 2018

OJVM

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Currently, canine obesity is a worldwide problem and is based on the excessive deposit of fat tissue, which plays an important role as a store of energy and endocrine organ. This study aimed to compare the values of systolic blood pressure, serum chemistry profile and glucose metabolism in eight obese dogs without endocrine diseases before and after 16 weeks of a weight loss program. A statistical difference was noticed in the serum levels of alkaline phosphatase, gamma glutamyl transferase, glucose, cholesterol and insulin, before and after the program. Besides, there was a statistical difference between the moments in systolic blood pressure, body weight and body condition scale. Therefore, it was concluded that the use of a diet rich in fiber and protein is suitable for performing weight loss and obese dogs undergoing a weight loss program presented a significant reduction in blood pressure, blood glucose, insulin, blood cholesterol, serum activity of alkaline phosphatase and gamma glutamyl transferase.

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Endocrine Hypertension in Small Animals

Cited by 43 publications

References 89 publications

Feline Diabetes Mellitus

Feline Diabetes Mellitus

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

Metabolic Parameters in Obese Dogs Undergoing to the Diet with Calorie Restriction

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