Endocrine involvement in granulomatosis with polyangiitis

Abstract

Endocrine involvement during the course of GPA is exceptional, and only a few sporadic observations were reported. Thus the exact meaning of endocrinopathies associated with this vasculitis is not yet well known. Fortuitous association or specific localization of vasculitis in the endocrine glands? The purpose of this minireview is to study the endocrine involvement in granulomatosis with polyangeiitis and to discuss its possible pathogenic mechanisms.

Thyroid Involvement in Eosinophilic Granulomatosis with Polyangiitis

“…Indeed, recent genome-wide association studies suggests the presence of two genetically distinct subgroups/phenotypes of EGPA: ANCA-positive and -negative subgroups [1,2]. Endocrine damage particularly that of the thyroid gland, are exceptional during systemic vasculitis [8][9][10][11][12][13]. They raise the problem of their mechanism (association of autoimmune diseases?…”

“…Or specific thyroid localization of vasculitis? ), As well as that of their treatment and prognostic implications [8][9][10][11][12][13].…”