Endocrine manifestations of systemic mastocytosis in bone

Greene, Loren Wissner; Asadipooya, Kamyar; Corradi, Patricia Freitas; Akin, Cem

doi:10.1007/s11154-016-9362-3

Cited by 32 publications

(26 citation statements)

References 39 publications

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“…Mast cells are now considered critical in allergy [100] and innate immunity in the skin [138,139] but also for immunity [101,140] and inflammation [141][142][143][144]. The possible role of CRH in cutaneous inflammatory diseases has also been reviewed [56,85].…”

Section: Stress Crh and Immune Cellsmentioning

confidence: 99%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

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Section: Stress Crh and Immune Cellsmentioning

confidence: 99%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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“…Several case studies and small clinical trials described a reduced bone mass and an increased fracture occurrence in patients with MC accumulation in the bone marrow (143)(144)(145)(146). Larger cohort studies confirmed the high prevalence of osteoporosis (up to ∼60%), and fragility fractures (up to ∼40%) in SM patients (147-150), as recently reviewed in more detail by Greene et al (151). The pathomechanisms of MC-induced bone loss are not yet fully understood.…”

Section: The Role Of Mast Cells In Bone Disorders Osteoporosismentioning

confidence: 89%

The Role of Mast Cells in Bone Metabolism and Bone Disorders

et al. 2020

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Mast cells (MCs) are important sensor and effector cells of the immune system that are involved in many physiological and pathological conditions. Increasing evidence suggests that they also play an important role in bone metabolism and bone disorders. MCs are located in the bone marrow and secrete a wide spectrum of mediators, which can be rapidly released upon activation of mature MCs following their differentiation in mucosal or connective tissues. Many of these mediators can exert osteocatabolic effects by promoting osteoclast formation [e.g., histamine, tumor necrosis factor (TNF), interleukin-6 (IL-6)] and/or by inhibiting osteoblast activity (e.g., IL-1, TNF). By contrast, MCs could potentially act in an osteoprotective manner by stimulating osteoblasts (e.g., transforming growth factor-β) or reducing osteoclastogenesis (e.g., IL-12, interferon-γ). Experimental studies investigating MC functions in physiological bone turnover using MC-deficient mouse lines give contradictory results, reporting delayed or increased bone turnover or no influence depending on the mouse model used. By contrast, the involvement of MCs in various pathological conditions affecting bone is evident. MCs may contribute to the pathogenesis of primary and secondary osteoporosis as well as inflammatory disorders, including rheumatoid arthritis and osteoarthritis, because increased numbers of MCs were found in patients suffering from these diseases. The clinical observations could be largely confirmed in experimental studies using MC-deficient mouse models, which also provide mechanistic insights. MCs also regulate bone healing after fracture by influencing the inflammatory response toward the fracture, vascularization, bone formation, and callus remodeling by osteoclasts. This review summarizes the current view and understanding of the role of MCs on bone in both physiological and pathological conditions.

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“…Auffällig war jedoch eine deutlich erhöhte Tryptase von 71 µg/l (Norm < 11,4), sodass der Verdacht auf eine systemische Mastozytose als weitere Ursache der Osteoporose gestellt wurde. [6,7]. Als Osteoporosetherapie wird aufgrund der aktuellen Studienlage eine antiresorptive Therapie mit Bisphosphonaten empfohlen.…”

Section: Fallbeschreibungunclassified

Multiple Wirbelkörperfrakturen bei einem 44-jährigen Mann – die Abklärung sekundärer Ursachen lohnt sich

Gollisch

Lamersdorf

Werner

et al. 2019

Arthritis und Rheuma

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ZusammenfassungWir beschreiben den Fall eines 44-jährigen Patienten, der sich 2011 mit akuten Rückenschmerzen und radiologisch nachgewiesener frischer LWK-Fraktur vorstellte. Neben der frischen Fraktur fielen ältere Kompressionsfrakturen im Bereich der Brust- und Lendenwirbelsäule auf. Die Knochendichtemessung zeigte eine ausgeprägte Osteoporose. Klinisch fiel der Patient durch kleine Hoden auf. Die Diagnostik bezüglich sekundärer Ursachen der Osteoporose zeigte nicht nur einen hypergonadotropen Hypogonadismus, sondern auch das Vorliegen einer systemischen Mastozytose. Die der Osteoporose zugrundeliegenden Pathologien steuerten die Therapieentscheidung. Neben einer Testosteronsubstitution wurde eine Bisphosphonattherapie eingeleitet. Hierunter konnte eine Stabilisierung erreicht werden. Die Knochendichte verbesserte sich um 8 %, und es traten keine weiteren osteoporotischen Frakturen auf. Der Fall zeigt die Wichtigkeit einer vollständigen Diagnostik bezüglich sekundärer Ursachen einer Osteoporose, insbesondere wenn ein ungewöhnlicher Kontext wie bei jungen Männern oder prämenopausalen Frauen vorliegt.

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Endocrine manifestations of systemic mastocytosis in bone

Cited by 32 publications

References 39 publications

Neuroendocrinology of the skin

Neuroendocrinology of the skin

The Role of Mast Cells in Bone Metabolism and Bone Disorders

Multiple Wirbelkörperfrakturen bei einem 44-jährigen Mann – die Abklärung sekundärer Ursachen lohnt sich

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