Endocrine-metabolic adaptations in Dorper ewes: comparison between single and twin pregnancies during gestation, parturition, and postpartum

Santarosa, Bianca Paola; Ferreira, Danilo Otávio Laurenti; Hooper, Henrique Barbosa; Sinzato, Yuri Karen; Damasceno, Débora Cristina; Polizel, Daniel Montanher; Fioratti, Eduardo Gorzoni; Santos, Vítor Hugo dos; Silva, Andreza A. da; Gonçalves, Roberto Calderón

doi:10.1007/s11250-022-03306-4

Cited by 5 publications

(1 citation statement)

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“…As sheep are an important source of animal protein, improving the pregnancy rate of ewes will not only improve the economic efficiency of the sector, but will also benefit human diets worldwide [1]. Pregnancy in ewes causes huge physiological and metabolic changes, and is a factor in determining the management of pregnant and nonpregnant ewes [2,3]. Exploring metabolic differences in pregnant and nonpregnant ewes could improve the understanding of the physiological or pathological characteristics and mechanisms in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Blood Metabolites and Faecal Microbial Communities in Nonpregnant and Early Gestation Ewes in Highly Cold Areas

Wu,

Yang,

Wang

et al. 2023

Biology

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Ewes undergo complex metabolic changes during pregnancy. Understanding the specific process of these changes is a necessary prerequisite in ewes for regulating and intervening in order to maintain pregnancies. However, there have been relatively few studies on the specific changes that occur in nutritional metabolism in pregnant ewes during early gestation, especially for some landrace ewes in highly cold areas. Therefore, this study aimed to (1) elucidate the changes in metabolites and microbial communities in pregnant ewes during early gestation using metabolomics and 16S ribosomal RNA gene (rDNA) amplicon sequencing approaches, and to (2) discover novel early pregnancy-induced biomarkers in the blood and faeces. Rams were placed together with ewes on D0 and removed on D45. During early gestation, blood and faecal samples were collected from ewes in a highly cold area for analysing the metabolites and microbial communities; these were retrospectively classified as the early gestation pregnant (EP) ewe group or the nonpregnant (NP) ewe group based on the lambing status recorded during the expected delivery period. The differences in the plasma biochemical parameters, plasma metabolites, and faecal microbial communities of pregnant and nonpregnant ewes were characterised. The GC, IL-6, O-acetyl-l-serine, L-glutamine, and 6-acetamido-2-oxohexanoic acid were screened out as potential biomarkers for evaluating the occurrence of early pregnancy. These novel early pregnancy-induced metabolites discovered in ewes might allow for the development of technologies to detect early pregnancies in sheep in highly cold areas.

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Section: Introductionmentioning

confidence: 99%