Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases

Salim, Alaa A.; Karim, Rooshdiya Z.; McCarthy, Stanley W.; Scolyer, Richard A.

doi:10.1097/pat.0b013e32835833d8

Cited by 15 publications

(17 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare low‐grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. Around 70 cases of EMPSGC have been reported so far (Table ). The tumor exhibits morphologic and immunophenotypical similarity to endocrine ductal carcinoma in situ (DCIS) or solid papillary carcinoma of the breast .…”

Section: Introductionmentioning

confidence: 99%

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We have found 29 cases published so far in the literature, one of them allegedly in an extrafacial location (chest) . The main locations were the eyelid (most cases) and the cheek.…”

mentioning

confidence: 99%

Endocrine mucin‐producing sweat gland carcinoma: a study of three cases and CK8, CK18 and CD5/6 immunoexpression

Fernández-Flores

Cassarino

2015

J Cutan Pathol

View full text Add to dashboard Cite

Endocrine mucin-producing sweat gland carcinoma is a cutaneous adnexal tumor that is rarely reported in the literature. We identified only 29 previously reported cases. All these cases share some clinical morphologic and immunohistochemical features. Among the immunohistochemical markers, cytokeratins 5/6, 8 and 18 (CK5/6, CK8 and CK18) had not been previously studied in this tumor. Although studies with cytokeratin Cam5.2 exist, we know at present that this marker does not correspond to antibodies CK8/18, but rather to CK7 and CK8. We studied three examples of endocrine mucin-producing sweat gland carcinoma with 18 immunostains. Our cases showed an immunoprofile CK8+, CK18+, CK5/6- (or only focally positive), CK7+, GCDFP-15+ (2 cases), estrogen receptor+, progesterone receptor+, HER2-, neuron-specific enolase + (2 cases), anti-synaptophysin+, chromogranin A +, CD56 variable (1 case +, 1 case-), CD57-, anti-human D2-40- (two cases), p63- or focally positive, smooth muscle actin + with variable pattern of expression and smooth muscle myosin heavy chain expressed in a peripheral discontinuous layer in some nodules, but absent in most.

show abstract

“…Regardless of gender, EMPSGC consistently expresses estrogen and progesterone receptors. All six reported cases of EMPSGC from male patients (including ours) with available information expressed both estrogen and progesterone receptors . Most examples of EMPSGC lacked discernible peripheral myoepithelial cells and about 50% of the cases were associated with an invasive mucinous carcinoma component .…”

Section: Discussionmentioning

confidence: 70%

“…EMPSGC is an extremely rare tumor of the skin. To the best of our knowledge, only 26 cases have been reported after it was established as a distinct entity, although it is likely that some have been reported in association with mucinous carcinomas in the literature. Among the previously reported cases, all occurred either in the periocular region (23 cases) or on the cheek (3 cases).…”

Section: Discussionmentioning

confidence: 99%

Endocrine mucin‐producing sweat gland carcinoma occurring on extra‐facial site: a case report

et al. 2014

View full text Add to dashboard Cite

Cutaneous endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a very rare low-grade malignant neoplasm analogous to the mammary solid-papillary carcinoma. It frequently expresses neuroendocrine markers and may show mucinous differentiation. Although the nodules are circumscribed, myoepithelial cells cannot be showed in most cases and about half of the cases are associated with invasive mucinous carcinoma. Hence, it has been suggested to be invasive and the precursor lesion of some primary cutaneous mucinous carcinomas. After being recognized as a distinct entity, all cases reported to date occurred either in the periocular region or on the cheek. Two thirds of the patients were female. Herein we present an unusual case of in situ EMPSGC on the chest wall skin of a middle-aged man.

show abstract

Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases

Cited by 15 publications

References 12 publications

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

Endocrine mucin‐producing sweat gland carcinoma: a study of three cases and CK8, CK18 and CD5/6 immunoexpression

Endocrine mucin‐producing sweat gland carcinoma occurring on extra‐facial site: a case report

Contact Info

Product

Resources

About