Endocrine Myopathies

Douglas, Michael E.; Hassan‐Smith, Zaki; Ruff, Robert L.

doi:10.1007/978-1-4614-6567-6_67

Cited by 1 publication

(2 citation statements)

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“…It was therefore interesting in our healthy cohort, that active 1α,25(OH) 2 D3 (but not inactive 25OHD3) correlates with muscle markers of maximum power, velocity and jump height, which are influenced by the proportion of type II fast twitch muscle fibers. These fibers are preferentially lost in endocrine myopathies as exemplified by severe vitamin D deficiency [ 2 , 28 ]. In a previously reported adolescent female cohort jump-plate mechanography measures were shown to have a positive relationship with 25OHD [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years there has been great interest in its non-skeletal actions, with growing evidence from epidemiological, basic and clinical studies that vitamin D status is associated with effects including those on muscle function, body fat, immunity and cardiovascular disease risk [ 1 ]. Myopathy has long-been recognised to co-exist with reduced bone mineralization in the severe vitamin D deficiency states of rickets and osteomalacia [ 2 ]. In view of the great public health burden of so-called ‘sarcopenia’ and age-associated declines in muscle strength and function, there is significant interest in whether vitamin D may have a role in improving the healthy lifespan.…”

Section: Introductionmentioning

confidence: 99%

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25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

et al. 2017

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Age-associated decline in muscle function represents a significant public health burden. Vitamin D-deficiency is also prevalent in aging subjects, and has been linked to loss of muscle mass and strength (sarcopenia), but the precise role of specific vitamin D metabolites in determining muscle phenotype and function is still unclear. To address this we quantified serum concentrations of multiple vitamin D metabolites, and assessed the impact of these metabolites on body composition/muscle function parameters, and muscle biopsy gene expression in a retrospective study of a cohort of healthy volunteers. Active serum 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3), but not inactive 25-hydroxyvitamin D3 (25OHD3), correlated positively with measures of lower limb strength including power (rho = 0.42, p = 0.02), velocity (Vmax, rho = 0.40, p = 0.02) and jump height (rho = 0.36, p = 0.04). Lean mass correlated positively with 1α,25(OH)2D3 (rho = 0.47, p = 0.02), in women. Serum 25OHD3 and inactive 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) had an inverse relationship with body fat (rho = -0.30, p = 0.02 and rho = -0.33, p = 0.01, respectively). Serum 25OHD3 and 24,25(OH)2D3 were also correlated with urinary steroid metabolites, suggesting a link with glucocorticoid metabolism. PCR array analysis of 92 muscle genes identified vitamin D receptor (VDR) mRNA in all muscle biopsies, with this expression being negatively correlated with serum 25OHD3, and Vmax, and positively correlated with fat mass. Of the other 91 muscle genes analysed by PCR array, 24 were positively correlated with 25OHD3, but only 4 were correlated with active 1α,25(OH)2D3. These data show that although 25OHD3 has potent actions on muscle gene expression, the circulating concentrations of this metabolite are more closely linked to body fat mass, suggesting that 25OHD3 can influence muscle function via indirect effects on adipose tissue. By contrast, serum 1α,25(OH)2D3 has limited effects on muscle gene expression, but is associated with increased muscle strength and lean mass in women. These pleiotropic effects of the vitamin D ‘metabolome’ on muscle function indicate that future supplementation studies should not be restricted to conventional analysis of the major circulating form of vitamin D, 25OHD3.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%