Endocrine profile associated with estrogen and progesterone receptors in leiomyoma and normal myometrium

Sadan, Oscar; B, van Iddekinge; Savage, Nerina; La, van der Walt; Zakut, Haim

doi:10.3109/09513599009030689

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Also the relation between these receptors seems to differ with a higher ER/PR ratio in leiomyomas than in myometrium (2). Accumulating evidence indicates that whereas elevated levels of progesterone down-regulate the estrogen receptor, estrogen may up-regulate the progesterone receptor in the human uterus (2,15,16). The functions of estrogen and progesterone in uterine smooth muscle cells might be complementary, with estrogen priming as a prerequisite for the optimal stimulation of proliferation by progesterone.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Wu¹,

Blanck²,

OLOVSSON³

et al. 2000

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 99%

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Wu¹,

Blanck²,

OLOVSSON³

et al. 2000

Acta Obstet Gynecol Scand

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“…The concept that progesterone suppresses the ER in fibroid tissue is further supported by the findings of Sadan et al (5), who found an inverse correlation between serum progesterone levels and fibroid ER concentration, using a ligand binding assay. The concept that progesterone suppresses the ER in fibroid tissue is further supported by the findings of Sadan et al (5), who found an inverse correlation between serum progesterone levels and fibroid ER concentration, using a ligand binding assay.…”

Section: Discussionmentioning

confidence: 75%

Sex Steroid Receptors in Human Myometrium and Fibroids: Changes during the Menstrual Cycle and Gonadotropin-Releasing Hormone Treatment¹

Englund

Blanck

Gustavsson

et al. 1998

The Journal of Clinical Endocrinology & Metabolism

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The content of estrogen and progesterone receptors (ER, PR) is higher in fibroid tissue than in homologous myometrium, and both receptors seem to be regulated by the levels of circulating sex steroids. Myometrial and fibroid tissues were recovered from women undergoing gynecological operations during different phases of the menstrual cycle and during treatment with an analogue of GnRH (GnRHa). Contents of ER and PR in the tissue cytosol were determined by enzyme immunoassay. The ER levels were significantly higher in fibroid tissue than in homologous myometrium in all the endocrine conditions. During the secretory phase, when luteal progesterone production is prominent, the ER levels in the myometrium and fibroids were lower than during the proliferative phase. During GnRHa treatment, the ER levels in both tissues were similar to those in the proliferative phase but significantly higher than in the secretory phase. The PR levels were also significantly higher in fibroids than in myometrium in all the different endocrine conditions. In both tissues, the PR levels were lower in the secretory phase and during GnRHa treatment, compared with the proliferative phase. Our data suggest that, in these categories of women, both ER and PR are overexpressed in fibroid tissue. Apparently, high progesterone levels down-regulate the ER in both fibroids and myometrium, whereas estrogen mediates the up-regulation of the PR during the proliferative phase. Increased knowledge about the mechanisms by which sex steroids regulate their own receptors in uterine tissues might provide a basis for development of new treatment strategies for women with fibroid disease.

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Endocrinology and paracrinology

et al. 1996

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Oestrogen and progesterone are promoters of uterine leiomyoma growth: oestrogen receptors (ER) and progesterone receptors (PR) are over-expressed in these tumours. Paradoxically, there is a heterogeneity in responsiveness of leiomyoma growth to oestrogen and progesterone in culture. In this study, leiomyoma and adjacent myometrium were obtained at hysterectomy. The effect of oestrogen and progesterone on steroid receptor maintenance was examined using minced explants. Quantitative enzyme-linked immunoassay and Northern analysis were performed to assess ER and PR protein and mRNA content respectively. There was an approximately 75% decrease in ER and PR protein content within 8 h of incubation in both leiomyoma and myometrium. The presence or absence of oestrogen and/or progesterone had no effect on receptor protein loss. Northern analysis indicated a parallel loss of ER and PR mRNA transcripts. These findings suggest that the ER and PR expression in leiomyoma may require other extracellular factors. In-vitro studies designed to test the effects of sex steroids and their respective inhibitors on growth and function of leiomyoma and myometrial cells should consider this phenomenon.

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Endocrine profile associated with estrogen and progesterone receptors in leiomyoma and normal myometrium

Cited by 4 publications

References 13 publications

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Sex Steroid Receptors in Human Myometrium and Fibroids: Changes during the Menstrual Cycle and Gonadotropin-Releasing Hormone Treatment¹

Endocrinology and paracrinology

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Endocrine profile associated with estrogen and progesterone receptors in leiomyoma and normal myometrium

Cited by 4 publications

References 13 publications

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Apoptosis, cellular proliferation and expression of p53 in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

Sex Steroid Receptors in Human Myometrium and Fibroids: Changes during the Menstrual Cycle and Gonadotropin-Releasing Hormone Treatment1

Endocrinology and paracrinology

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Sex Steroid Receptors in Human Myometrium and Fibroids: Changes during the Menstrual Cycle and Gonadotropin-Releasing Hormone Treatment¹