Endocrine, prostatic vascular, and proapoptotic changes in dogs with benign prostatic hyperplasia treated medically or surgically

Lima, Camila Bruna de; Angrimani, Daniel de Souza Ramos; Flores, Renato Bueno; Vannucchi, Camila Infantosi

doi:10.1016/j.domaniend.2020.106601

Cited by 5 publications

(8 citation statements)

References 28 publications

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“…Although Lima et al. (2021) reported that castration decreased the prostate size in dogs with BPH, involution times did not occur with the same speed as in our work, in which a very fast prostatic involution was obtained; we were unable to find differences between animals with BPH and dogs with normal dimensions of the prostate gland in relation to age and weight at the second week post‐castration. This information is useful for the veterinarian when presenting therapeutic options to canine owners.…”

Section: Discussioncontrasting

confidence: 94%

“…Percentages of volume decrease exceeded those observed by Lima et al. (2021), who found a maximum decrease in patients presumptively diagnosed with BPH, by means of clinical signs, prostatic fluid assessment and prostate biometry by B‐mode ultrasound, of 34.9% at 60 days after castration. Studies that used GnRH agonists observed reduction percentages of 46% at week 5 in canines without HPB (Ludwig et al., 2009), 52% at week 8 and 64% at week 26 after starting treatment in 53 male dogs (35.9% with and without small prostatic cysts and distinct clinical signs of BPH) (Goericke‐Pesch et al., 2010).…”

Section: Discussioncontrasting

confidence: 59%

“…In addition, Lima et al. (2021) reported a volume reduction of approximately 20% after 60 days of finasteride treatment. Comparing studies has limitations, as they are carried out in different animals and conditions, but data in our study show that the percentage decrease in prostate volume in animals with BPH is greater than those pharmacologically treated.…”

Section: Discussionmentioning

confidence: 99%

“…According to what is known regarding the general size of the prostate, relative volume and other prostate variables (height, width and length) decreased over time in castrated animals of both groups, due to hormonal suppression via orchiectomy (Cohen et al., 1995; Lima et al., 2021). Although Lima et al.…”

Section: Discussionmentioning

confidence: 99%

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Post‐castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia

Cazzuli

Damián

Molina

et al. 2021

Reprod Domestic Animals

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The objective of this study was to evaluate the effect of castration on dimensions of the prostate by B‐mode ultrasound for 90 days, as well as to evaluate changes in serum concentrations of testosterone and oestradiol in clinically healthy canines and those with benign prostatic hyperplasia (BPH). Three groups of animals were used: healthy canines castrated on day 0 (HCC, n = 8), canines with a diagnosis of benign prostatic hyperplasia (BPHC, n = 9) castrated on day 0 and healthy uncastrated canines (IHCC, n = 10). Prostate size was obtained by B‐mode ultrasound, while blood samples were collected (days 0, 7, 14, 28, 60 and 90 post‐castration) to determine the serum testosterone and oestradiol concentration. Castration did not affect serum oestradiol concentrations. Castration led to a decrease in serum testosterone (reaching values <20 ng/dl in the first week, p < .05), causing a gradual decrease in dimensions of prostate parameters relative to body weight (p < .05). Canines with BPHC had similar prostate dimensions as the IHCC group 2 weeks post‐castration. In relation to the prostate's relative parameters, the decrease with time was greater in canines with BPHC than those in the HCC group. When evaluating parameters as a percentage of relative change, the decrease with time was similar in both castrated groups, except for relative length percentage, which presented a more pronounced decline in BPHC canines than HCC canines. In conclusion, castration is an effective, fast and long‐lasting treatment for canine patients with BPH, as it causes a rapid decrease in blood testosterone concentrations and a decrease in glandular volume, but does not affect serum oestradiol concentrations. This study did not determine the mechanisms of action, but allowed us to observe (based on morphometric variables) that characteristics of prostate involution after castration differed between canines with BPH and healthy canines.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Post‐castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia

Cazzuli

Damián

Molina

et al. 2021

Reprod Domestic Animals

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“…Previous animal experiments have demonstrated that the decrease of androgens after castration or antiandrogen therapy may induce a prostate shrinkage by apoptosis ( 6 , 7 ). Likewise, medical treatment for BPH, such as the use of 5α-reductase inhibitors (finasteride), has also shown the apoptosis of prostatic epithelial cells leading to prostate size reduction both in men and dogs ( 8 , 9 ). The depletion of androgen effects by different targeted therapies has confirmed its effectiveness on prostate involution.…”

Section: Introductionmentioning

confidence: 99%

Prostatic artery occlusion: initial findings on pathophysiological response in a canine prostate model

Lucas‐Cava¹,

Sánchez‐Margallo²,

Moreno-Lobato³

et al. 2022

Transl Androl Urol

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Background: Prostatic artery embolization (PAE) is an alternative treatment for symptomatic benign prostatic hyperplasia (BPH) in men. A technical modification of conventional PAE has been developed in a canine prostate model consisting of prostatic artery occlusion (PAO) using Onyx ® whose therapeutic effect is prostate shrinkage. However, the underlying mechanisms are not well clarified. The purpose was to evaluate the biological mechanisms responsible for therapeutic effects of PAO in the canine prostate.Methods: Ten adult male beagles (5.0±0.82 years) underwent PAO with Onyx-18 (n=7) and prostatic artery angiography as control (n=3). Blood samples were taken at different time points of follow-up (baseline, 1 week, 2 weeks, 1 month, 3 months and 6 months) to measure the serum canine prostate specific esterase (CPSE). MRI examinations were also performed to document the prostate volume (PV) before and after interventions at different time points of follow-up. Prostates were harvested at 2 weeks (n=2) in the PAOgroup, and the remaining ones (n=8) at 6 months for the determinations of intraprostatic testosterone and dihydrotestosterone (DHT) by ELISA, apoptosis by TUNEL assay and histopathological study. Results:The mean serum CPSE concentration started to decrease significantly from 2 weeks to 6 months after PAO along with PV compared with baseline data. In addition, a moderate but significant correlation was observed between CPSE and PV (r=0.655, P=0.000). Regarding intraprostatic androgens, testosterone was significantly higher after PAO than control (19.70 vs. 4.87 ng/mL, P=0.002), whereas DHT was lower but no significant (112.52 vs. 138.35 pg/mL, P=0.144). In histological study, PAO induced a severe hemorrhagic necrosis in the whole prostates along with inflammatory cell infiltration at early 2 weeks, and then diffuse interstitial fibrosis with atrophy of the glandular epithelium and intraprostatic cavity formation at 6 months.Apoptosis was detected in all specimens with higher apoptotic index after PAO at 2 weeks (7.35%) and at 6 months (4.38%) compared with control (2.64%), without statistically significant difference between groups.

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Expression of apoptotic proteins in the pulmonary artery of dogs with pulmonary hypertension secondary to degenerative mitral valve disease

Sakarin

Rungsipipat

Surachetpong

2022

Research in Veterinary Science

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Endocrine, prostatic vascular, and proapoptotic changes in dogs with benign prostatic hyperplasia treated medically or surgically

Cited by 5 publications

References 28 publications

Post‐castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia

Post‐castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia

Prostatic artery occlusion: initial findings on pathophysiological response in a canine prostate model

Expression of apoptotic proteins in the pulmonary artery of dogs with pulmonary hypertension secondary to degenerative mitral valve disease

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