Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays

Du, Guizhen; Huang, Hongyu; Hu, Jialei; Qin, Yufeng; Wu, Di; Lee, Song; Xia, Yankai; Wang, Xinru

doi:10.1016/j.chemosphere.2013.01.012

Cited by 80 publications

(45 citation statements)

References 54 publications

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“…In addition, PFASs seem to affect testosterone concentrations by decreasing the expression of genes involved in steroid biosynthesis (Shi et al, 2007;Du et al, 2013). PFOA, PFOS and PFDA affect both estradiol and testosterone (Biegel, Liu, Hurtt, & Cook, 1995;Bookstaff, Moore, Ingall, & Peterson, 1990;A.…”

Section: Discussionmentioning

confidence: 99%

“…PFASs antagonize the androgen receptor activity (Du et al, 2013); the effects on the male reproductive system include increased germ cell apoptosis (Feng et al, 2009) and decreased weight of the reproductive organs (Shi et al, 2007). In addition, PFASs seem to affect testosterone concentrations by decreasing the expression of genes involved in steroid biosynthesis (Shi et al, 2007;Du et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…PFASs influence the expression of estrogen-responsive genes in animal studies (Benninghoff et al, 2011), and PFAS-induced changes in sex hormone biosynthesis have been reported in vitro (Du et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

Lind

Priskorn

Lassen

et al. 2017

Reproductive Toxicology

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In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend < 0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8 mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

Lind

Priskorn

Lassen

et al. 2017

Reproductive Toxicology

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“…The zebrafish embryo/larvae has become a systematic, sensitive and easily operated mode animal for identify endocrine disruption [27]. Several zebrafish genes, such as CYP19a, CYP19b, ER␣, and VTG are wellknown biomarker genes responsive to environmental endocrine disruptors [28][29][30][31][32]. Therefore, a combined in vitro and in vivo approach is an efficient way to gain a complete understanding of the properties of endocrine disruptors.…”

Section: Introductionmentioning

confidence: 99%

Disruption of endocrine function in H295R cell in vitro and in zebrafish in vivo by naphthenic acids

Wang

Cao

Sun

et al. 2015

Journal of Hazardous Materials

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“…However, they have been reported to have endocrine disrupting properties [38][39][40]. PFAAs are structurally similar to natural long-chain fatty acids and may displace them in biochemical processes and at receptors, such as peroxisome proliferator-activated receptor alpha (PPARα) and the liver-fatty acid binding protein (L-FABP).…”

Section: Perfluoroalkyl Carboxylic Acids (Pfcas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

et al. 2015

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Background: There is a growing concern in Sweden and elsewhere that continued emissions of per-and polyfluoroalkyl substances (PFASs) may cause environmental as well as human health effects. PFASs are a broad class of man-made substances that have been produced and used in both commercial products and industrial processes for more than 60 years. Although the production and use of some PFASs has been phased-out in some parts of the world, it is not known what effect these actions to date have had on PFAS concentrations in the environment. Owing to the wide diversity of PFASs, it is difficult to generalize their properties, environmental fate and production histories. However, the strength and stability of the C-F bond renders the perfluoroalkyl moieties resistant to heat and environmental degradation. Several PFASs are now occurring even in very remote areas in large parts of the world, but the environmental transport and fate of substances within this group is not well understood. A systematic review may be able to determine whether the concentrations of these substances in different environments are changing in any particular direction with time, and whether the phase-outs have had any effects on the concentration trends. Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations in the environment will be performed in the scientific literature as well as in other reports. Relevant samples include both abiotic and biological samples including humans. No particular time, document type, language or geographical constraints will be applied. Two authors will screen all retrieved articles. Double screening of about 10% of the articles will be performed by all authors at both title/abstract and full-text levels. Kappa tests will be used to test if the screening is consistent. Relevant articles will be critically appraised by four authors (double checking of 25% of the articles). Quality assessment will focus on selection bias, dating of samples, sample integrity and analytical procedures. Data synthesis will be based on statistical analysis of temporal concentration trends.

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Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays

Cited by 80 publications

References 54 publications

Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

Disruption of endocrine function in H295R cell in vitro and in zebrafish in vivo by naphthenic acids

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

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