Endocrine Rhythms in a Nonhuman Primate, the Rhesus Monkey1

Quabbe, Hans-Jürgen; Gregor, Michael; Bumke-Vogt, Christine; Witt, I.; Giannella-Neto, Daniel

doi:10.1159/000407999

Cited by 5 publications

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“…As a matched control group was available for comparison, the impact of venipuncture and handling (Herndon, Turner, Perachio, Blank, & Collins, 1984) is controlled for in the present study. The variability of plasma GH in the pigtail monkeys may reflect the episodic nature of GH release (Quabbe, Gregor, Bumke-Vogt, Witt, & Giannella-Neto, 1983), although this was not apparent as increased variability in the bonnet monkey. In fact, variability in the bonnet monkeys was quite small as indicated in Figure 3.…”

Section: Discussionmentioning

confidence: 92%

Total cortisol, free cortisol, and growth hormone associated with brief social separation experiences in young macaques

Laudenslager

Boccia

Berger

et al. 1995

Developmental Psychobiology

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Many behavioral, immunological, and physiological consequences or brief maternal separation in bonnet (Macaca radiata) and pigtail monkeys (Macaca nemistrina) have been documented. However, the impact of social separation on plasma cortisol and growth hormone is unknown for these particular species. In the present study, the behavioral and endocrinological consequences of a 2-week maternal separation in socially housed infant bonnet and pigtail monkeys were followed. In seven pairs (separated and matched control) of bonnet and six pairs of pigtail infants, plasma was obtained under baseline, separated, and reunion conditions twice weekly for the duration of the study. Blood samples were obtained from both infants of the pair in approximately 10 min. Plasma total cortisol, free cortisol, and growth hormone were measured in these samples. Focal animal behavioral observations were made on all subjects twice daily throughout the study period. In both species, total cortisol and free cortisol rose immediately following maternal separation in comparison to the matched nonseparated controls and returned to basal levels (e.g., that of matched nonseparated controls) following reunion with the mother. In contrast, plasma growth hormone rose only in the pigtail infants over a time course that peaked around the time of reunion. Multiple regression techniques indicated for the first week of separation, in the separated but not control subjects, that mean plasma free and total cortisol was positively related to distress behaviors (vocalization and postural slouch) observed during this week and negatively related to social behaviors (play and proximity to others) noted during the same period. In contrast, plasma growth hormone was related to both species and sex of the subjects but unrelated to behavioral variables.

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Section: Discussionmentioning

confidence: 92%

Total cortisol, free cortisol, and growth hormone associated with brief social separation experiences in young macaques

Laudenslager

Boccia

Berger

et al. 1995

Developmental Psychobiology

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Hypothalamic control of GH secretion: Pathophysiology and clinical implications

1985

Acta neurochir

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GH is secreted episodically. Its pattern is regulated by the interplay of a releasing and a release-inhibiting hormone of hypothalamic origin. Modulation occurs by metabolic factors (glucose, free fatty acids, ketone bodies, amino acids). Altered GH secretion has been observed in states of metabolic derangement such as diabetes mellitus, malnutrition and obesity. Further modulation occurs by extrahypothalamic CNS structures. In man--but not in animals, including subhuman primates--sleep has an important effect on GH secretion. A defective GH secretory pattern has been found to occur in several states of sleep disturbance, such as sleep deprivation, narcolepsy, severe psychosocial derangement, the apallic syndrome. Other CNS influences on GH secretion are related to stress, emotional changes and psychiatric disturbances. The exact mechanisms by which most of these influences are relayed to the GH secretory apparatus of the hypothalamus remain yet to be investigated.

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The functions of sleep: Further analysis

Cai¹

1991

Physiology & Behavior

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Endocrine Rhythms in a Nonhuman Primate, the Rhesus Monkey1

Cited by 5 publications

References 0 publications

Total cortisol, free cortisol, and growth hormone associated with brief social separation experiences in young macaques

Total cortisol, free cortisol, and growth hormone associated with brief social separation experiences in young macaques

Hypothalamic control of GH secretion: Pathophysiology and clinical implications

The functions of sleep: Further analysis

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