Endocrine small cell carcinoma of the bladder: a case report

Châari, C.; Krichen-Makni, S.; Toumi, Nabil; Fakhfekh, H.; Ellouze, S.; Ayadi, Lobna; Frikha, M.; Mhiri, Mohamed Nabil; Boudawara, T.

doi:10.1007/s10269-007-0823-x

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…First described by Koss in 1975 [6], the SCCB is described by the literature as a very uncommon BCa type, with an overall prevalence of 0.5-0.7% [1,2,7]. Despite its prevalence, it is reported to be an aggressive malignancy because of its high metastatic potential even when the bladder lesion appears as a "small lesion" [7][8][9]. Usually, the image found on the mucosa of the bladder is described as a necrotic ulcerated lesion of around 4-10 cm and has been difficult to differentiate from a transitional cell carcinoma (TCC) [7,9].…”

Section: Discussionmentioning

confidence: 99%

Primary Small-Cell Carcinoma of the Urinary Bladder: A Case Report and Literature Review

Garcia-Becerra,

Arias-Gallardo,

Juarez-Garcia

et al. 2024

Cureus

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Small-cell carcinoma of the bladder (SCCB) is an uncommon and aggressive malignancy of the urinary tract. Its clinical presentation often mimics that of other bladder neoplasms, posing a diagnostic challenge. This case report presents a rare instance of SCCB in a 65-year-old female, shedding light on the diagnostic journey and emphasizing the need for heightened and prompt clinical suspicion due to its aggressive nature. The patient presented to the urological department with hematuria, dysuria, and hypogastric pain. Initial investigations revealed a bladder mass, prompting biopsies with inconclusive results. A comprehensive histopathological examination, including immunohistochemistry, confirmed a SCCB. A computed tomography (CT) scan was used to evaluate local and distal extention. Following the initial evaluation, a referral to an oncological service was needed. Diagnoses encompassed SCCB, with interventions that comprise chemotherapy without radical cystectomy. Despite the rarity of SCCB, timely and accurate diagnosis facilitated a tailored multidisciplinary approach, leading to prompt clinical oncology management. This case demonstrates the importance of meticulous diagnostic evaluation in rare malignancies, guiding individualized therapeutic strategies for optimal patient outcomes.

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