Endocrinologic Aspects of Dysfunctional Uterine Bleeding

Lg, Sobrinho; Kase, Nathan

doi:10.1097/00003081-197006000-00013

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abnormal hCG secretion causes gynecomastia in men, which is a distinct clinical finding that may often lead to hormonal studies. On the other hand, amenorrhea and dysfunctional uterine bleeding, which can result from an elevated hCG level in women (18), are not very unusual findings and do not always lead to endocrine examinations or to chest roentgenograms, especially in women of childbearing age. This may explain why hCG-producing lung cancers in women have rarely been reported.…”

Section: Discussionmentioning

confidence: 99%

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Nagai¹,

Nishimura²,

Takahashi³

et al. 2000

Japanese Journal of Clinical Oncology

View full text Add to dashboard Cite

Abbreviations: hCG, human chorionic gonadotropin; β-hCG, β-subunit of human chorionic gonadotropin; SCC, squamous cell carcinoma; HB, hepatitis type B; NSCLC, non-small cell lung cancer We describe a rare case of pulmonary squamous cell carcinoma secreting human chorionic gonadotropin (hCG) and its β-subunit (β-hCG) in a young female smoker. A 31-year-old mother of one child had been suffering from dysfunctional uterine bleeding for about 1 year. Pelvic examinations and abdominal ultrasonography yielded no abnormal findings and no signs of pregnancy. She developed a pain in the right chest and a huge (12 × 10 cm) squamous cell carcinoma was diagnosed in the right lower lobe. The serum hCG and β-hCG levels were high: hCG 5611 mIU/ml (normal upper limit 0.7 mIU/ml), β-hCG 12 238 mIU/ml (normal upper limit 0.5 mIU/ml). The patient underwent right lower lobectomy and systematic lymph node dissection. Microscopic study showed a poorly differentiated squamous cell carcinoma. The pathological stage was T2N0M0, stage IB. Immunohistochemical staining of the tumor was strongly positive for hCG. The serum hCG level returned to normal 1 month after the operation, while an additional 2 months were necessary for the β-hCG level to normalize. Dysfunctional uterine bleeding disappeared and the patient is doing well, with no signs of recurrence, 9 months after the resection.

show abstract

Section: Discussionmentioning

confidence: 99%

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Nagai¹,

Nishimura²,

Takahashi³

et al. 2000

Japanese Journal of Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…DUB has been referred to anovulation (7,10), but abnormal corpus luteum function has also been included by others (2,4,9). Neoplasms are excluded from the syndrome, but, since endometrial polyps are not true neo plasms (5), they may be considered to belong to DUB (11).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Aid of Endometrium Biopsy

Vanbogaert¹

1979

Gynecol Obstet Invest

View full text Add to dashboard Cite

The 784 cases, from which 701 complained of abnormal uterine bleeding, were reviewed by age groups, presenting symptoms, sex steroid medication and endometrial findings. Endometrial polyps and endometritis, which showed an incidence of 17.5 and 10.0%, respectively, were correlated with clinicopathologic findings. Peri- and postmenopausal bleeders were investigated with special reference to hormone therapy and endometrial patterns. Dysfunctional uterine bleeding was diagnosed in 48.7% of the subjects during reproductive years. Pathologic findings were found to explain the clinical symptoms in 60.6% of the entire study group.

show abstract

Benign Diseases of the Endometrium

Kurman¹,

Mazur²

1982

Pathology of the Female Genital Tract

View full text Add to dashboard Cite

Endocrinologic Aspects of Dysfunctional Uterine Bleeding

Cited by 6 publications

References 0 publications

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Diagnostic Aid of Endometrium Biopsy

Benign Diseases of the Endometrium

Contact Info

Product

Resources

About