Endocrinology of male sexual dysfunction

Janmohamed, Salim; Bouloux, Pierre-Marc

doi:10.1002/9781118746509.ch5

Male Sexual Dysfunction 2016

DOI: 10.1002/9781118746509.ch5

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Endocrinology of male sexual dysfunction

Salim Janmohamed

Pierre-Marc Bouloux

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2022

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Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review

Hamzehnejadi

Tavakoli

Homayouni

et al. 2022

Sexual Medicine Reviews

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Introduction Erectile dysfunction (ED) is a substantial cause of dissatisfaction among many men. This discontentment has led to the emergence of various drug treatment options for this problem. Objectives Unfortunately, due to various interactions, contraindications, and side effects, systemic therapies such as phosphodiesterase-5 inhibitors (including sildenafil, tadalafil, vardenafil, avanafil, etc.) are not welcomed in many patients. These problems have led researchers to look for other ways to reduce these complications. Methods This article holistically reviews the efficacy of topical prostaglandins and their role in treating ED. We sought to provide a comprehensive overview of recent findings on the current topic by using the extensive literature search to identify the latest scientific reports on the topic. Results In this regard, topical and transdermal treatments can be suitable alternatives. In diverse studies, prostaglandins, remarkably PGE1 (also known as alprostadil), have been suggested to be an acceptable candidate for topical treatment. Conclusion Numerous formulations of PGE1 have been used to treat patients so far. Still, in general, with the evolution of classical formulation methods toward modern techniques (such as using nanocarriers and skin permeability enhancers), the probability of treatment success also increases.

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Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review

Hamzehnejadi

Tavakoli

Homayouni

et al. 2022

Sexual Medicine Reviews

View full text Add to dashboard Cite

show abstract

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Endocrinology of male sexual dysfunction

Cited by 1 publication

References 77 publications

Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review

Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review

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