Endocytic Control of Cellular Signaling at the Primary Cilium

Pedersen, Lotte B.; Mogensen, Johanne B.; Christensen, Søren Tvorup

doi:10.1016/j.tibs.2016.06.002

Cited by 101 publications

(106 citation statements)

References 110 publications

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“…Ciliary transmembrane proteins are believed to be transported from the trans -Golgi network or recycling endosomes by vesicular carriers that target specifically to the periciliary membrane, where transition fibers from the distal appendage of the basal body are attached (Sung and Leroux, 2013; Pedersen et al. , 2016).…”

Section: Discussionmentioning

confidence: 99%

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

Hirano

Katoh

Nakayama

2017

MBoC

125

156

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Section: Discussionmentioning

confidence: 99%

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

Hirano

Katoh

Nakayama

2017

MBoC

125

156

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“…9,11 The ciliary pocket has been shown to be a site where endocytosis and exocytosis needed in signal transduction take place. 12 Furthermore, as described above, cilia are also known to play a secretory role, and in neuroepithelial cells they are putative sites of Prominin-enriched extracellular Figure 1. Schematic representation depicting the main features of primary cilia in neuroepithelial cells.…”

Section: Cilia and The Cell Proliferation/neurogenesis Balancementioning

confidence: 94%

Neuron's little helper: The role of primary cilia in neurogenesis

2016

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The generation of new neurons involves a great variety of cell-extrinsic and cell-intrinsic signals. The primary cilium, long regarded as an "evolutionary vestige," has emerged as an essential signaling hub in many cells, including neural progenitors and differentiating neurons. Most progenitors harbor an apically-localized primary cilium, which is assembled and disassembled following the cell cycle, while the presence, position and length of this organelle appears to be even more variable in differentiating neurons. One of the main extracellular cues acting through the cilium is Sonic Hedgehog, which modulates spatial patterning, the progression of the cell cycle and the timing of neurogenesis. Other extracellular signals appear to bind to cilia-localized receptors and affect processes such as dendritogenesis. All the observed dynamics, as well as the many signaling pathways depending on cilia, indicate this organelle as an important structure involved in neurogenesis.

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“…Some of the best described examples of ciliary receptors include the 12 transmembrane SHH receptor PTCH1, which when bound to ligand exits the cilium concomitantly with ciliary entry of SMO, thereby initiating a series of downstream events to activate GLI-mediated target gene expression during development and in the adult (Mukhopadhyay and Rohatgi 2014;Pedersen et al 2016), class A and B GPCRs that regulate various behavioral responses and tissue homeostasis (Schou et al 2015;Hilgendorf et al 2016), RTKs that function in cell migration and proliferation , and TGF-b receptors (TGF-bRs) that are important in heart development (Koefoed et al 2014). The latter two classes of receptors will be described in more detail below.…”

Section: Overview Of Signaling In Primary Ciliamentioning

confidence: 99%

Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling

Christensen

Morthorst

Mogensen

et al. 2016

Cold Spring Harb Perspect Biol

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102

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Since the beginning of the millennium, research in primary cilia has revolutionized our way of understanding how cells integrate and organize diverse signaling pathways during vertebrate development and in tissue homeostasis. Primary cilia are unique sensory organelles that detect changes in their extracellular environment and integrate and transmit signaling information to the cell to regulate various cellular, developmental, and physiological processes. Many different signaling pathways have now been shown to rely on primary cilia to function properly, and mutations that lead to ciliary dysfunction are at the root of a pleiotropic group of diseases and syndromic disorders called ciliopathies. In this review, we present an overview of primary cilia-mediated regulation of receptor tyrosine kinase (RTK) and transforming growth factor b (TGF-b) signaling. Further, we discuss how defects in the coordination of these pathways may be linked to ciliopathies.

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Endocytic Control of Cellular Signaling at the Primary Cilium

Cited by 101 publications

References 110 publications

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

Neuron's little helper: The role of primary cilia in neurogenesis

Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling

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