Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Yoshihiro; Sugimoto, Seiichiro; Bessho, Rieko; Arai, Mari; Kiyohara, Hiroki; Ono, Keiko; Nanki, Kosaku; Murata, Makoto; Mizuno, Shinta; Hosoe, Naoki; Shimoda, Masayuki; Abe, Takayuki; Inoue, Nagamu; Ogata, Haruhiko; Iwao, Yasushi; Kanai, Takanori

doi:10.1055/s-0043-106556

Cited by 44 publications

(47 citation statements)

References 13 publications

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“…Using endocytoscopy, Nakazato et al . recently assessed histological healing in 64 ulcerative colitis patients in clinical and endoscopic remission.…”

Section: Endopathology and Computer‐assisted Diagnosismentioning

confidence: 99%

“…Therefore, endocytoscopy imaging might become a predictive indicator for relapse of patients with ulcerative colitis although these initial data need to be confirmed in a larger cohort setting. Using endocytoscopy, Nakazato et al 37 recently assessed histological healing in 64 ulcerative colitis patients in clinical and endoscopic remission. They found that endocytoscopy can be used to assess histological healing in patients with ulcerative colitis without the need for biopsy specimens.…”

Section: Endocytoscopymentioning

confidence: 99%

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Advanced endoscopic imaging for diagnosis of inflammatory bowel diseases: Present and future perspectives

Sivanathan

Tontini

Möhler

et al. 2018

Digestive Endoscopy

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Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) causing severe damage of the luminal gastrointestinal tract. Differential diagnosis between both disease entities is sometimes awkward requiring a multifactorial pathway, including clinical and laboratory data, radiological findings, histopathology and endoscopy. Apart from disease diagnosis, endoscopy in IBD plays a major role in prediction of disease severity and extent (i.e. mucosal healing) for tailored patient management and for screening of colitis-associated cancer and its precursor lesions. In this state-of-the-art review, we focus on current applications of endoscopy for diagnosis and surveillance of IBD. Moreover, we will discuss the latest guidelines on surveillance and provide an overview of the most recent developments in the field of endoscopic imaging and IBD.

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“…Using endocytoscopy, Nakazato et al . recently assessed histological healing in 64 ulcerative colitis patients in clinical and endoscopic remission.…”

Section: Endopathology and Computer‐assisted Diagnosismentioning

confidence: 99%

Section: Endocytoscopymentioning

confidence: 99%

Advanced endoscopic imaging for diagnosis of inflammatory bowel diseases: Present and future perspectives

Sivanathan

Tontini

Möhler

et al. 2018

Digestive Endoscopy

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“…[6][7][8][9] Endocytoscopy (EC; CF Y-0058-I prototype and H290ECI; Olympus Corp), which is performed with a 520-fold ultra-magnifying contact microscope, is comparable with other advanced technologies in terms of prediction of histologic severity. [10][11][12] However, such accuracy using these technologies has been achieved only by experts. Furthermore, interobserver variation in categorizing endoscopic disease activity is widely suspected.…”

mentioning

confidence: 99%

Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video)

Maeda

Kudo

Mori

et al. 2019

Gastrointestinal Endoscopy

184

128

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Background and Aims: In the treatment of ulcerative colitis (UC), an incremental benefit of achieving histologic healing beyond that of endoscopic mucosal healing has been suggested; persistent histologic inflammation increases the risk of exacerbation and dysplasia. However, identification of persistent histologic inflammation is extremely difficult using conventional endoscopy. Furthermore, the reproducibility of endoscopic disease activity is poor. We developed and evaluated a computer-aided diagnosis (CAD) system to predict persistent histologic inflammation using endocytoscopy (EC; 520-fold ultra-magnifying endoscope). Methods: We evaluated the accuracy of the CAD system using test image sets. First, we retrospectively reviewed the data of 187 patients with UC from whom biopsy samples were obtained after endocytoscopic observation. EC images and biopsy samples of each patient were collected from 6 colorectal segments: cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. All EC images were tagged with reference to the biopsy sample's histologic activity. For validation samples, 525 validation sets of 525 independent segments were collected from 100 patients, and 12,900 EC images from the remaining 87 patients were used for machine learning to construct CAD. The primary outcome measure was the diagnostic ability of CAD to predict persistent histologic inflammation. Its reproducibility for all test images was also assessed.

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“…23 Agreement between histological remission regarding the EC score and the Geboes score had a j value of 0.72, and the EC score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. 23 In the other discussion topics, autofluorescence imaging (AFI) and its usefulness for differential diagnosis between non-neoplastic and neoplastic lesions was described. Likewise, as neoplastic tissues are highlighted without requiring exogenous fluorophore administration in AFI, it was found to be effective in histopathological diagnosis.…”

Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 89%

“…For this reason, EC is closer to a ‘virtual biopsy’ than magnifying chromoendoscopy. In this core session, a study whereby EC showed significantly higher diagnostic accuracy for the prediction of neoplastic and non‐neoplastic lesions than conventional endoscopy, and correlation between the EC findings and the degree of inflammation as determined by histopathology in UC was described . Agreement between histological remission regarding the EC score and the Geboes score had a κ value of 0.72, and the EC score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86 …”

Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 98%

Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

Oka

Tanaka

Sano

et al. 2017

Digestive Endoscopy

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At each of the 89th to the 92nd congresses of the Japan Gastroenterological Endoscopy Society, a series of featured discussion sessions concerning advanced diagnostic endoscopy in the lower gastrointestinal tract were presented. In total, 45 lectures were presented in this subject area. It was shown that, in recent years, several convenient and less invasive colonoscopic modalities have been developed. This review article summarizes these core sessions and the efficacy of the techniques discussed.

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Endocytoscopy can be used to assess histological healing in ulcerative colitis

Cited by 44 publications

References 13 publications

Advanced endoscopic imaging for diagnosis of inflammatory bowel diseases: Present and future perspectives

Advanced endoscopic imaging for diagnosis of inflammatory bowel diseases: Present and future perspectives

Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video)

Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

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